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EPhos Pd G4

EPhos Pd G4 structure

CAS No.: 2132978-44-8

Chemical Name:: EPhos Pd G4

Synonyms: Dicyclohexyl-[2-propan-2-yloxy-6-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphanium;Dicyclohexyl[3-(1-methylethoxy)-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine-κP](methanesulfonato-κO)[2′-(methylamino-κN)[1,1′-biphenyl]-2-yl-κC]palladium;EPhos Pd G4;EPhos Catalyst;dicyclohexyl-[2-isopropoxy-6-(2,4,6-triisopropylphenyl)phenyl]phosphane (N-methyl-2-phenyl-anilino)-methylsulfonyloxy-palladium;Methanesulfonato{Dicyclohexyl[3-(1-methylethoxy)-2',4',6'-tris(1-methylethyl)-1,1'-biphenyl-2-yl]phosphine}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II);Methanesulfonicacid{bicyclohexyl(3-isopropoxy-2',4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphane}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),EphosPdG4;Dicyclohexyl[3-(1-methylethoxy)-2′,4′,6′-tri(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine-κP](methanesulfonate-κO)[2′-(methylamino-κN)[1,1′-biphenyl]-2-yl-κC]palladium;Methanesulfonato{Dicyclohexyl[3-(1-methylethoxy)-2',4',6'-tris(1-methylethyl)-1,1'-biphenyl-2-yl]phosphine}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (Ephos Pd G4)

CBNumber:: CB13375823

Molecular Formula:: C50H70NO4PPdS

Molecular Weight:: 918.55

MDL Number:: MFCD31692235

MOL File:: 2132978-44-8.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:54

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EPhos Pd G4 Properties

storage temp.	2-8°C, protect from light
form	powder or crystals
Appearance	Brown to dark brown Solid
InChIKey	HFYQPKNKOSULDB-UHFFFAOYSA-M
SMILES	[Pd+]c5c(cccc5)c6c(cccc6)NC.P(C4CCCCC4)(C3CCCCC3)c1c(cccc1c2c(cc(cc2C(C)C)C(C)C)C(C)C)OC(C)C.[S](=O)(=O)([O-])C
UNSPSC Code	12352128
NACRES	NA.21

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

EPhos Pd G4 price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	901220	EPhos Pd G4	2132978-44-8	1g	$327	2026-04-30	Buy
Sigma-Aldrich	901220	EPhos Pd G4	2132978-44-8	5 g	$1290	2026-04-30	Buy
Sigma-Aldrich	901220	EPhos Pd G4	2132978-44-8	1 unit	$1210	2025-07-31	Buy
Sigma-Aldrich	901220	EPhos Pd G4	2132978-44-8	250mg	$136	2023-01-07	Buy
aablocks	AA01W7OU	EPhos Pd G4 98%	2132978-44-8	100mg	$36	2026-05-31	Buy

Product number	Packaging	Price	Buy
901220	1g	$327	Buy
901220	5 g	$1290	Buy
901220	1 unit	$1210	Buy
901220	250mg	$136	Buy
AA01W7OU	100mg	$36	Buy

EPhos Pd G4 Chemical Properties, Uses, Production

Uses

Buchwald palladacycle precatalyst with EPhos ligand for Pd-catalyzed C–N cross-coupling between primary amines and aryl halides to form 2-arylaminooxazoles. Catalyst system was reported with NaOPh (CDS001581).
It is a fourth generation (G4) Buchwald precatalyst that is similar to the third generation (G3) precatalysts except that the amino group on the biphenyl backbone is methylated. This modification helps to prevent the limitations of using the third generation precatalysts. It is air, moisture and thermally-stable and shows good solubility in common organic solvents. BrettPhos Pd G4 is highly useful in cross-coupling reactions. Some of its excellent features include lower catalyst loadings, shorter reaction time, and efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

EPhos Pd G4 Preparation Products And Raw materials

Raw materials

Preparation Products

EPhos Pd G4 Suppliers

Global Suppliers ( 60)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Taiyu New Materials Co., Ltd.	18627786697	tyxcchem@163.com	China	92	58
WuHan Taiyukaishang Chemical Co., Ltd.	027-027-87680032 18963957250	taiyuchem@163.com	China	180	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai Haozhixiang Biotechnology Co., Ltd	526763801 13301653310	526763801@qq.com	China	7983	55
Zhengzhou Kingorgchem Chemical Technology Co., Ltd.gy Co., Ltd.	0371-65511006 18625597674	info@kingorgchem.com;sales@kingorgchem.com	China	806	55
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9780	55
LaaJoo	021-60702684 18516024827	huang.jiayi@sinocompound.com	China	2280	58
Jiaxing Deyi Chemical Co., Ltd.	86-0573-85866609 18367600069	945717149@qq.com	China	9506	58
Aikon International Limited	025-58851090 13913916777	sales01@aikonchem.com	China	15947	58

Supplier	Advantage
Wuhan Taiyu New Materials Co., Ltd.	58
WuHan Taiyukaishang Chemical Co., Ltd.	55
Bide Pharmatech Ltd.	60
Sigma-Aldrich	80
Shanghai Haozhixiang Biotechnology Co., Ltd	55
Zhengzhou Kingorgchem Chemical Technology Co., Ltd.gy Co., Ltd.	55
Tianjin Kailiqi Biotechnology Co., Ltd.	55
LaaJoo	58
Jiaxing Deyi Chemical Co., Ltd.	58
Aikon International Limited	58

View Latest Price from EPhos Pd G4 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-25	EPhos Pd G4 2132978-44-8	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2025-12-23	Ephos Pd G4 2132978-44-8		1g	98%	500g	XINXIANG RUNYU MATERIAL CO., LTD.

EPhos Pd G4
2132978-44-8
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Ephos Pd G4
2132978-44-8
98%
XINXIANG RUNYU MATERIAL CO., LTD.

EPhos Pd G4 Spectrum

EPhos Pd G4(2132978-44-8)³¹PNMR

2132978-44-8 (EPhos Pd G4) Related Search:

Methanesulfonato(2-bis(3,5-di(trifluoromethyl)phenylphosphino)-3,6-dimethoxy-2',6'-bis(dimethylamino)-1,1'-biphenyl )(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) SPhos Palladacycle Gen. 4 MorDalPhos Pd G4 XPhos Pd G4 Xantphos Pd G3

BrettPhos Pd G3 t-BuXphos Palladacycle Gen. 4 Methanesulfonato 2-dicyclohexylphosphino-2-(N,N-dimethylamino)biphenyl(2′-amino-1,1′-biphenyl-2-yl) palladium(II) Methanesulfonate(2-Dicyclohexylphosphino-2'-methyl)(2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II) (Mephos Pd G3) QPhos Pd G3

VPhos Pd G4 RockPhos Pd G3 t-BuBrettPhos Palladacycle Gen. 3 SPhos Pd G3 cataCXium A Pd G3

XantPhos Pd G4 Methanesulfonato(triphenylphosphine)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (PPH3 PD G3) RuPhos Palladacycle Gen. 4

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EPhos Pd G4 Methanesulfonato{Dicyclohexyl[3-(1-methylethoxy)-2',4',6'-tris(1-methylethyl)-1,1'-biphenyl-2-yl]phosphine}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (Ephos Pd G4) EPhos Catalyst Methanesulfonato{Dicyclohexyl[3-(1-methylethoxy)-2',4',6'-tris(1-methylethyl)-1,1'-biphenyl-2-yl]phosphine}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) dicyclohexyl-[2-isopropoxy-6-(2,4,6-triisopropylphenyl)phenyl]phosphane (N-methyl-2-phenyl-anilino)-methylsulfonyloxy-palladium Methanesulfonicacid{bicyclohexyl(3-isopropoxy-2',4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphane}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),EphosPdG4 Dicyclohexyl[3-(1-methylethoxy)-2′,4′,6′-tri(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine-κP](methanesulfonate-κO)[2′-(methylamino-κN)[1,1′-biphenyl]-2-yl-κC]palladium Dicyclohexyl[3-(1-methylethoxy)-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine-κP](methanesulfonato-κO)[2′-(methylamino-κN)[1,1′-biphenyl]-2-yl-κC]palladium Dicyclohexyl-[2-propan-2-yloxy-6-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphanium 2132978-44-8