N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride
![N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Structure](CAS/GIF/245520-69-8.gif)
- CAS No.
- 245520-69-8
- Chemical Name:
- N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride
- Synonyms
- Sch 79797;SCH797972HCl;SCH 79797 dihydrochl;SCH 79797 DIHYDROCHLORIDE;N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine;3-N-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine;7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine,N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-;N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diaminedihydrochloride;N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride
- CBNumber:
- CB1341669
- Molecular Formula:
- C23H25N5
- Molecular Weight:
- 371.48
- MDL Number:
- MFCD12910520
- MOL File:
- 245520-69-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Properties
| Boiling point | 644.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| solubility | DMSO : 50 mg/mL (134.60 mM; Need ultrasonic) |
| pka | 8.73±0.40(Predicted) |
| form | Solid |
| color | Light yellow to brown |
| InChIKey | NNJTXSQXGHYXAJ-UHFFFAOYSA-N |
| SMILES | Cl.Cl.[n]2(c3c(c4c(nc(nc4N)NC5CC5)cc3)cc2)Cc1ccc(cc1)C(C)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1939 | SCH 79797 hydrochloride ≥98% (HPLC) | 245520-69-8 | 5 mg | $116 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1939 | SCH 79797 hydrochloride ≥98% (HPLC) | 245520-69-8 | 25 mg | $467 | 2026-04-30 | Buy |
| ChemScene | CS-0003683 | SCH79797 99.74% | 245520-69-8 | 5mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0003683 | SCH79797 99.74% | 245520-69-8 | 10mg | $184 | 2026-06-04 | Buy |
| ChemScene | CS-0003683 | SCH79797 99.74% | 245520-69-8 | 25mg | $401 | 2026-06-04 | Buy |
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Chemical Properties, Uses, Production
Uses
SCH 79797 Dihydrochloride is a selective PAR1 antagonist.
Definition
ChEBI: N3-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine is a member of quinazolines.
Biological Activity
Potent, selective non-peptide PAR 1 receptor antagonist (IC 50 = 70 nM). Inhibits haTRAP-induced- but not g-thrombin-, ADP- or collagen-induced human platelet aggregation. Also selectively blocks PAR 1 agonist- or thrombin-induced increases in cytosolic Ca 2+ in vascular smooth muscle cells.
in vivo
SCH79797 (2.5-250 μg/kg; intravenous injection; male Sprague Dawley rats) treatment immediately before or during ischemia reduces myocardial necrosis following I/R in the intact rat heart in two rat models of myocardial ischemia/reperfusion (I/R) injury. This response is dose-dependent with the optimal dose being 25 μg/kg[4].
| Animal Model: | Male Sprague Dawley rats (8 weeks of age) with myocardial I/R injury[4] |
| Dosage: | 2.5 μg/kg, 10 μg/kg, 25 μg/kg, 50 μg/kg, 100 μg/kg, and 250 μg/kg |
| Administration: | Intravenous injection |
| Result: | Immediately before or during ischemia reduced myocardial necrosis following I/R in the intact rat heart. |
IC 50
PAR1: 70 nM (IC50); PAR1: 35 nM (Ki)
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 587 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Chengdu Ainahua Chemicals Co., Ltd. | 028-86612776; 13699069380 | 515238037@qq.com | China | 970 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| NORANA GROUP | 027-59209883 17386138556 | service@nornachem.com | China | 4873 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
