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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine structure

CAS No.: 479633-63-1

Chemical Name:: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Synonyms: Tofacitinib Impurity 20;4-Chloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine;Tofacitinib-9;Tofacitinib imurity;Tofatinib Impurity 1;Tofatinib Impurity P;Tofacitinib Impurity R;Tofacitinib Impurity 53;Tofacitinib Impurity 163;4-Chloro-7-tosyl-7H-pyrro...

CBNumber:: CB32452480

Molecular Formula:: C13H10ClN3O2S

Molecular Weight:: 307.76

MDL Number:: MFCD09907939

MOL File:: 479633-63-1.mol

TDS File:: TDS

Last updated:2026-05-28 01:03:46

Product description	Number	Pack Size	Price
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Aldrich	ADE000077	1g	$761
4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine >96.0%(HPLC)(N)	C3036	1g	$74
4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine >96.0%(HPLC)(N)	C3036	5g	$296
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine ≥95%	OR317249	1g	$102
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine ≥95%	OR317249	5g	$307
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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Properties

Melting point	145.0 to 149.0 °C
Boiling point	505.3±60.0 °C(Predicted)
Density	1.49
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly)
form	powder to crystal
pka	1.73±0.30(Predicted)
color	White to Orange to Green
InChI	InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3
InChIKey	BTOJSYRZQZOMOK-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	Xn
Risk Statements	22
HazardClass	IRRITANT
HS Code	2933599590

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	ADE000077	4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Aldrich	479633-63-1	1g	$761	2023-06-20	Buy
TCI Chemical	C3036	4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine >96.0%(HPLC)(N)	479633-63-1	1g	$74	2025-07-31	Buy
TCI Chemical	C3036	4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine >96.0%(HPLC)(N)	479633-63-1	5g	$296	2023-06-20	Buy
Apolloscientific	OR317249	4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine ≥95%	479633-63-1	1g	$102	2026-06-04	Buy
Apolloscientific	OR317249	4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine ≥95%	479633-63-1	5g	$307	2026-06-04	Buy

Product number	Packaging	Price	Buy
ADE000077	1g	$761	Buy
C3036	1g	$74	Buy
C3036	5g	$296	Buy
OR317249	1g	$102	Buy
OR317249	5g	$307	Buy

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Uses,Production

Uses

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.

Pharmaceutical Applications

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine features a unique pyrrolo[2,3-d]pyrimidine structure, which enhances its potential as a building block in the synthesis of various biologically active molecules. Its sulfonyl group contributes to its reactivity, making it a valuable intermediate in the creation of targeted therapies, particularly in oncology and anti-inflammatory applications.

Synthesis

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.

References

[1] Patent: WO2007/117494, 2007, A1. Location in patent: Page/Page column 61-62

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine synthesis

Synthesis of 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine and Tosyl chloride

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Tetrahydrofuran Sodium hydride Tosyl chloride 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Preparation Products

4-IODO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Suppliers

Global( 440)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Minbiotech Co., Ltd.	+8617315815539	sales@minbiotech.com	CHINA	129	58
Huanfu Industrial Co.，（Shanghai）Ltd.	+86-18001856580	2415195517@qq.com	China	43	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14032	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1796	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	809	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3004	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60

Supplier	Advantage
Shanghai Minbiotech Co., Ltd.	58
Huanfu Industrial Co.，（Shanghai）Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-12	4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-11	4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1
$5.00
99%
Henan Fengda Chemical Co., Ltd

4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1
98.0%
Shaanxi Dideu New Materials Co. Ltd

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Spectrum

4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE(479633-63-1)¹HNMR

479633-63-1(4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine)Related Search:

N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride DEAZAPURINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Trifluorothymine 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine

2-Thiouracil 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine

4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib Impurity T

1of4

Tofacitinib Impurity R 4-Chloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine 4-CHLORO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE 4-Chloro-7-tosyl-7H-pyrro... 4-Chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-7-p-toluenesulphonyl-7H-pyrrolo[2,3-d]pyrimidine 7H-Pyrrolo[2,3-D]pyriMidine,4-chloro-7-[(4-Methylphenyl)sulfonyl]- 4-Chloro-7-tosyl-7H-pyrrolo[2 4-chloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine Tofacitinib-9 4-Chloro-7-[(4-methylbenzene)sulfonyl]pyrrolo[2,3-d]pyrimidine Tofacitinib imurity 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-2-yl) amino)piperidin-1-yl)-3-oxopropanenitrile 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib Impurity 53 Tofacitinib Impurity 20 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine > 4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrim... Azilsartan medoxomil impurity345 Tofatinib Impurity 1 Tofatinib Impurity P Tofacitinib Impurity 163 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 98% 4-chlorine-7-Tosyl-7H-Pyrrole[2,3-D]Pyrimidine 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo 4-Chloro-7-tosy1-7Hpyrrolo[2,3-d]pyrimidine 4-Chloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 3-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1 Heterocycle-Pyrimidine series ADVANCED INT.