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CTAP

CTAP structure

CAS No.: 103429-32-9

Chemical Name:: CTAP

Synonyms: CTAP;CTAP-NH2;CTAP,CTA;CTAP, ≥95%;7)-disulfide;CTAP, mu opioid antagonist;CYS2, TYR3, ARG5, PEN7-AMIDE;M.W. 1104.30 C51H69N13O11S2;D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2;H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2

CBNumber:: CB1349599

Molecular Formula:: C51H69N13O11S2

Molecular Weight:: 1104.3

MDL Number:: MFCD00671434

MOL File:: 103429-32-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:09

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CTAP Properties

storage temp.	-20°C
form	Solid
color	off-white
Water Solubility	Soluble to 1 mg/ml in water
Sequence	{d-Phe}-Cys-Tyr-{d-Trp}-Arg-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
InChIKey	OFMQLVRLOGHAJI-FGHAYEPSSA-N
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

CTAP price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C6352	CTAP ≥95%	103429-32-9	1mg	$263	2026-04-30	Buy
Sigma-Aldrich	5.08316	CTAP - CAS 103429-32-9 - Calbiochem	103429-32-9	1MG	$154	2026-04-30	Buy
Cayman Chemical	14959	CTAP	103429-32-9	1mg	$79	2021-12-16	Buy
Usbiological	255053	CTAP Asreported	103429-32-9	1mg	$409	2026-06-03	Buy
Usbiological	217291	CTAP (Mu Opioid Receptor Antagonist, CTAP) ~95%(HPLC)	103429-32-9	1mg	$523	2026-06-03	Buy

Product number	Packaging	Price	Buy
C6352	1mg	$263	Buy
5.08316	1MG	$154	Buy
14959	1mg	$79	Buy
255053	1mg	$409	Buy
217291	1mg	$523	Buy

CTAP Chemical Properties, Uses, Production

Uses

CTAP acts as a selective μ-opioid receptor antagonist with a multitude of applications including the regulation of aggressive behavior in mammals. Activation of μ-opioid receptors in the central nucleus of the amygdala, is responsible for mechanisms related to the control of sodium appetite and regulation of sodium intake.

Uses

CTAP has been used as a μ-opioid receptor (MOR) antagonist:

to study the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitor isoleucine-proline-isoleucine (IPI) and vildagliptin in carrageenan-induced inflammation
to study the role of MOR in glutamate and gamma-aminobutyric acid (GABA) efflux during predator stress in rats
to determine the endogenous opioid peptide involved in blocking pain induced by activated gastrin-releasing peptide (Grp⁺) neurons

Biochem/physiol Actions

CTAP is a peptide antagonist produced from somatostatin analogs.

in vivo

CTAP (0-1 mg/kg, IP, single) blocks morphine’s antinociceptive effect^[1].
CTAP (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements^[1].
CTAP is stable in the blood and serum of rats (T_1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance^[2].
CTAP is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%)^[2].

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	0, 0.1, 0.5, 1 mg/kg
Administration:	IP, single
Result:	Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg.

IC 50

μ Opioid Receptor/MOR: 3.5 nM (IC₅₀); δ Opioid Receptor/DOR: 4500 nM (IC₅₀)

storage

Store at -20°C

CTAP Preparation Products And Raw materials

Raw materials

Preparation Products

CTAP Suppliers

Global Suppliers ( 135)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29985	65
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7993	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai Xilong Biochemical Technology Co., Ltd.	021-52907766-8042		China	9928	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Chengdu Huachun Technology Co., Ltd	400-1166-196 15982826727	cdhxsj@163.com	China	14571	60

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
TargetMol Chemicals Inc.	58
Sigma-Aldrich	80
Shanghai Xilong Biochemical Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Chengdu Huachun Technology Co., Ltd	60

View Latest Price from CTAP manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-03-06	CTAP 103429-32-9	$1.00	1g	≥98%		Career Henan Chemical Co

CTAP
103429-32-9
$1.00
≥98%
Career Henan Chemical Co

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H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2 D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2 CTAP CYS2, TYR3, ARG5, PEN7-AMIDE H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(Cys2-Pen7) CTAP, ≥95% 7)-disulfide M.W. 1104.30 C51H69N13O11S2 CTAP-NH2 D-Phe-L-Cys-L-Tyr-D-Trp-L-Arg-L-Thr-L-Pen-L-Thr-NH2 D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2(DISULFIDE BRIDGE:CYS2-PEN7) CTAP,CTA L-Threoninamide,D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-,cyclic (2® D-Phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-L-threoninamide cyclic (2-7)-disulfide H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (Disulfide bond between Cys2 and Pen7) L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH? (Disulfide bond between Cys? and Pen?) CTAP, mu opioid antagonist 103429-32-9 C51H67N13O11S C51H69N13O11S2 Neuropeptides Opioid Peptides Other Opioid Peptides Other Opioid PeptidesPeptides for Cell Biology Opioid receptor and opioid-like receptor Peptide