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CTOP
- CAS No.
- 103429-31-8
- Chemical Name:
- CTOP
- Synonyms
- NALTRIBEN;NTB;CTOP;threoninamide;CYS2,TYR3,ORN5,PEN7-AMIDE;M.W. 1062.26 C50H67N11O11S2;(Tyr3,Orn5,Pen7)-Octreotate amide;Cys2, Tyr3, Orn5, Pen7 amide - CTOP;CTOP, mu opioid receptor antagonist;DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
- CBNumber:
- CB9260913
- Molecular Formula:
- C50H67N11O11S2
- Molecular Weight:
- 1062.26
- MDL Number:
- MFCD00076708
- MOL File:
- 103429-31-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-20 15:44:38
| Boiling point | 1491.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.42±0.1 g/cm3(Predicted) |
| RTECS | XO8578200 |
| storage temp. | -20°C |
| pka | 9.90±0.15(Predicted) |
| form | Powder |
| color | white |
| Water Solubility | Soluble to 1 mg/ml in water |
| Sequence | {D-Phe}-Cys-Tyr-{D-Trp}-{Orn}-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7) |
| InChIKey | PZWWYAHWHHNCHO-FGHAYEPSSA-N |
| FDA UNII | G5H9PK5HEK |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
CTOP price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P5296 | CTOP ≥97% (HPLC) | 103429-31-8 | 1mg | $302 | 2026-04-30 | Buy |
| Usbiological | 445154 | CTOP | 103429-31-8 | 1mg | $523 | 2026-06-03 | Buy |
| Usbiological | 445154 | CTOP | 103429-31-8 | 10mg | $2796 | 2026-06-03 | Buy |
| Usbiological | 255055 | CTOP Asreported | 103429-31-8 | 1mg | $478 | 2026-06-03 | Buy |
| Usbiological | 217292 | CTOP (Mu Opioid Receptor Antagonist, CTOP) ~98%(HPLC) | 103429-31-8 | 1mg | $545 | 2026-06-03 | Buy |
CTOP Chemical Properties, Uses, Production
Uses
CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.
Uses
CTOP has been used:
- to study the anxiogenic effects induced by CTOP in mice and rat.
- to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
- to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).
General Description
D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.
Biochem/physiol Actions
Selective ligand for μ-opioid receptors.
in vivo
CTOP (0-0.5 nmol, ICV, once) antagonizes the analgesic effect of morphine in a dose-dependent manner[1].
CTOP (0-2 nmol, ICV, once) causes withdrawal hypothermia and a loss of body weight in morphine-dependent animals[1].
CTOP (0-1.5 nmol per side, Intra-VTA injection) enhances extracellular dopamine levels in the nucleus accumbens and dose-dependently enhances locomotor activity[2].
| Animal Model: | Male CFLP mice (25-30 g)[1] |
| Dosage: | 0, 0.001, 0.05, 0.075, 0.1, and 0.5 nmol (made up in artificial cerebrospinal fluid (CSF) and kept in plastic tubes at -25℃ until use) |
| Administration: | Intracerebroventricular (i.c.v.) administration, once |
| Result: | Antagonized the analgesic effect of morphine in a dose-dependent manner, antagonized the morphine-induced hypermotility in a dose-dependent manner. |
| Animal Model: | Male CFLP mice (25-30 g, Acute dependence to morphine was induced by a single dependence-inducing (100 mg/kg) dose of morphine-HC1)[1] |
| Dosage: | 0, 0.001, 0.05, 0.2, and 2 nmol |
| Administration: | Intracerebroventricular (i.c.v.) administration, once |
| Result: | Decreased the body temperature in a dose-dependent manner, and caused withdrawal hypothermia and a loss of body weight in morphine-dependent animals. |
| Animal Model: | Long-Evans hooded rats (12, male, 350-450 g)[2] |
| Dosage: | 0, 0.015, 0.15, and 1.5 nmol per side |
| Administration: | Intra-VTA (ventral tegmental area) injection |
| Result: | Enhanced extracellular dopamine levels in the nucleus accumbens, dose-dependently increased activity, whereas had no effect on feeding and drinking behavior. |
IC 50
μ Opioid Receptor/MOR
storage
Store at -20°C
CTOP Preparation Products And Raw materials
Raw materials
Preparation Products
CTOP Suppliers
Global Suppliers ( 115)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
103429-31-8 (CTOP) Related Search:
N-Carbobenzyloxy-L-threoninamide,N2-(Benzyloxycarbonyl)-L-threoninamide,Z-L-THREONINAMIDE,N-Benzyloxycarbonyl-L-Threoninamide,CBZ-L-THREONINAMIDE
isopropyl methyl disulphide
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CTAP
CTOP
L-Threoninamide
EPOXOMICIN
Z-Thr-NH2
technetium Tc 99m dioxo-1-(alanyl-seryl-threonyl-theonyl-threonyl-asparaginyl-tyrosyl-threoninamide)cyclam
phenylalanyl--cysteinyl-tyrosyl-tryptophyl-arginyl-penicillaminyl-threoninamide
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NTB
D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR AMIDE
D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
CTOP
CYS2,TYR3,ORN5,PEN7-AMIDE
[CYS2, TYR3, ORN5, PEN7]-SOMATOSTATIN 14 (7-14), AMIDE
H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
H-D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2 (DISULFIDE BRIDGE: 2-7)
FCYW(ORN)T(PEN)T-NH2 (DISULFIDE BRIDGE: 2-7)
phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2, (Disulfide bond between Cys2 and Pen7)
M.W. 1062.26 C50H67N11O11S2
D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-3-Mercapto(1)-L-Val-L-Thr-NH2
D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Orn-L-Thr-L-Pen(1)-L-Thr-NH2
[Cys2, Tyr3, Orn5, Pen7-amide]-Somatostatin 14 (7-14)
Cys2, Tyr3, Orn5, Pen7 amide - CTOP
CTOP, (Tyr3,Orn5,Pen7)-Octreotate aMide
(Tyr3,Orn5,Pen7)-Octreotate amide
phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond)
L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide
Cys2, Tyr3, Orn5, Pen7-NH2]-Somatostatin14(7-14)
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond) TFA Salt
CTOP, mu opioid receptor antagonist
NALTRIBEN
103429-31-8
C50H67N11O11S2
Opioid Peptides
Other Opioid Peptides
Peptides
BioChemical
Biochemicals and Reagents
Amino Acids and Peptides
peptide
Neuropeptides
Opioid Peptides
Other Opioid Peptides
Other Opioid PeptidesPeptides for Cell Biology
Opioid receptor and opioid-like receptor
