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ChemicalBook >> CAS DataBase List >>4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Structure
4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE structure
CAS No.
139512-70-2
Chemical Name:
4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE
Synonyms
BUTTPARK 44\03-90;TIMTEC-BB SBB003959;4-chloro-5-fluoro-2-aMino-aniline;4-fluoro-5-chlorophenylenediamine;-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE;4-CHLORO-1,2-DIAMINO-5-FLUOROBENZENE;1-CHLORO-4,5-DIAMINO-2-FLUOROBENZENE;1,2-DIAMINO-4-CHLORO-5-FLUOROBENZENE;4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE;4-CHLORO-5-FLUOROBENZENE-1,2-DIAMINE
CBNumber:
CB1382390
Molecular Formula:
C6H6ClFN2
Molecular Weight:
160.58
MDL Number:
MFCD00042485
MOL File:
139512-70-2.mol
MSDS File:
SDS
Last updated:2026-05-27 23:32:34
Product description Number Pack Size Price
4-Chloro-5-fluorobenzene-1,2-diamine FC64359 5g $900
4-Chloro-5-fluorobenzene-1,2-diamine FC64359 50g $900
4-Chloro-5-fluorobenzene-1,2-diamine FC64359 2g $900
4-Chloro-5-fluorobenzene-1,2-diamine FC64359 25g $900
4-Chloro-5-fluorobenzene-1,2-diamine FC64359 10g $900
More product size
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4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Properties

Melting point 110-112 °C
Boiling point 316.2±37.0 °C(Predicted)
Density 1.457±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 3.16±0.10(Predicted)
Appearance Brown to reddish brown Solid
CAS DataBase Reference 139512-70-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Warning
Hazard statements  H302-H311-H315-H319-H332-H335
Precautionary statements  P280h-P305+P351+P338-P309-P310
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-20/21/22-36-22
Safety Statements  36/37/39-26
RIDADR  2811
Hazard Note  Harmful/Irritant
HazardClass  IRRITANT
HazardClass  6.1
PackingGroup  Ⅲ
HS Code  2921599090
NFPA 704
0
2 0

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FC64359 4-Chloro-5-fluorobenzene-1,2-diamine 139512-70-2 5g $900 2026-06-04 Buy
Biosynth FC64359 4-Chloro-5-fluorobenzene-1,2-diamine 139512-70-2 50g $900 2026-06-04 Buy
Biosynth FC64359 4-Chloro-5-fluorobenzene-1,2-diamine 139512-70-2 2g $900 2026-06-04 Buy
Biosynth FC64359 4-Chloro-5-fluorobenzene-1,2-diamine 139512-70-2 25g $900 2026-06-04 Buy
Biosynth FC64359 4-Chloro-5-fluorobenzene-1,2-diamine 139512-70-2 10g $900 2026-06-04 Buy
Product number Packaging Price Buy
FC64359 5g $900 Buy
FC64359 50g $900 Buy
FC64359 2g $900 Buy
FC64359 25g $900 Buy
FC64359 10g $900 Buy

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Chemical Properties,Uses,Production

Chemical Properties

grey to light brown powder

Biological Activity

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE has been shown to have a high frequency of human activity using a patch clamp technique on human erythrocytes and also inhibits bacterial growth by binding to DNA dependent RNA polymerase, thereby preventing transcription and replication.

Synthesis

5-CHLORO-4-FLUORO-2-NITROANILINE

104222-34-6

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE

139512-70-2

The general procedure for the synthesis of 4-chloro-5-fluoro-o-phenylenediamine from 5-chloro-4-fluoro-2-nitroaniline was as follows: first, the reducing agent, hydrazine monocarbonate, was prepared by slow neutralization of 12.5 mL of hydrazine hydrate with 12.5 mL of 90% formic acid under ice-bath conditions. Subsequently, the compound 5-chloro-4-fluoro-2-nitroaniline (6 g, 0.03 mol) was dissolved in 20 mL of methanol and zinc powder (4 g, 0.06 mol) was added. The above solution was mixed with the prepared hydrazine monocarbonate solution and stirred at room temperature under nitrogen protection (Note: the reaction is exothermic and accompanied by gas production). The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was filtered and the filtrate concentrated. The residue was dissolved in dichloromethane and washed twice with saturated brine solution to remove excess of hydrazine monoformate. The organic layers were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to afford the target product 4-chloro-5-fluoro-o-phenylenediamine (89% yield, melting point 84-86 °C).

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 230 - 240

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Preparation Products And Raw materials

Raw materials

5-CHLORO-4-FLUORO-2-NITROANILINE ZINC Methanol

Preparation Products

6-chloro-7-fluoro-2,3-diphenylquinoxaline

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14301 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501 product@acmec-e.com China 33301 58
Aladdin Scientific 		tp@aladdinsci.com United States 50108 58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. 		+8618950047208 ellena@amitychem.com China 43392 58
Allfluoro Pharmaceutical Company Limited 		+86-400-0216110 +86-15958047586 sales@allfluoro.com China 11380 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53799 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Win-Win chemical CO., Limited 		58
Henan Fengda Chemical Co., Ltd 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. 		58
Allfluoro Pharmaceutical Company Limited 		58
DAYANG CHEM (HANGZHOU) CO.,LTD 		58

View Lastest Price from 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE pictures 2020-02-02 -CHLORO-5-FLUORO-O-PHENYLENEDIAMINE
139512-70-2
 $1.00 1KG 97% 100kg Career Henan Chemical Co

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE Spectrum

4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE(139512-70-2)1HNMR

139512-70-2(4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE)Related Search:

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TIMTEC-BB SBB003959 1,2-DIAMINO-4-CHLORO-5-FLUOROBENZENE 1-CHLORO-4,5-DIAMINO-2-FLUOROBENZENE 4-CHLORO-1,2-DIAMINO-5-FLUOROBENZENE 4-CHLORO-5-FLUORO-1,2-PHENYLENEDIAMINE 4-CHLORO-5-FLUOROBENZENE-1,2-DIAMINE 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE BUTTPARK 44\03-90 4-Chloro-1,2-diamino-5-fluorobenzene~1,2-Diamino-4-chloro-5-fluorobenzene 4-Chloro-1,2-diamino-5-fluorobenzene 98% 4-Chloro-1,2-diamino-5-fluorobenzene98% 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 99% 4-Chloro-5-fluoro-o-phenylenediamine,99% 4-Chloro-5-fluorobenzene-1,2-diamine 98% 4-Chloro-5-fluorophenylene-1,2-diamine, 5-Chloro-4-fluorophenylene-1,2-diamine, 1-Chloro-4,5-diamino-2-fluorobenzene 4-chloro-5-fluoro-2-aMino-aniline 1,2-BenzenediaMine, 4-chloro-5-fluoro- 1,2-DiaMino-4-chloro-5-fluorobenzene[4,5-diaMino-2-chlorofluorobenzene] -CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 4-Chloro-5-fluoro-1,2-benzenediamine 4-fluoro-5-chlorophenylenediamine 139512-70-2 Fluorine series