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4-Chloro-5-Bromopyrimidine

4-Chloro-5-Bromopyrimidine Structure
4-Chloro-5-Bromopyrimidine structure
CAS No.
56181-39-6
Chemical Name:
4-Chloro-5-Bromopyrimidine
Synonyms
4-Chloro-5-Bromopyrimidine;4-Chloro-5-bromopyrimidin...;Pyrimidine, 5-bromo-4-chloro-;4-Chloro-5-Bromopyrimidine ISO 9001：2015 REACH
CBNumber:
CB71270902
Molecular Formula:
C4H2BrClN2
Molecular Weight:
193.43
MDL Number:
MFCD09750158
MOL File:
56181-39-6.mol
MSDS File:
SDS
Last updated:2026-05-28 02:19:03
Product description Number Pack Size Price
5-Bromo-4-chloropyrimidine >98% OR902595 1g $21
5-Bromo-4-chloropyrimidine >98% OR902595 5g $45
5-Bromo-4-chloropyrimidine >98% OR902595 25g $202
5-Bromo-4-chloropyrimidine >98% OR902595 100g $799
4-Chloro-5-bromopyrimidine 95% AS12368 1g $32
More product size
Request For Quotation

4-Chloro-5-Bromopyrimidine Properties

Boiling point 250.7±20.0 °C(Predicted)
Density 1.859±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -1.41±0.16(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H332-H335-H312-H302-H319-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501
HS Code  2933599590

4-Chloro-5-Bromopyrimidine price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR902595 5-Bromo-4-chloropyrimidine >98% 56181-39-6 1g $21 2026-06-04 Buy
Apolloscientific OR902595 5-Bromo-4-chloropyrimidine >98% 56181-39-6 5g $45 2026-06-04 Buy
Apolloscientific OR902595 5-Bromo-4-chloropyrimidine >98% 56181-39-6 25g $202 2026-06-04 Buy
Apolloscientific OR902595 5-Bromo-4-chloropyrimidine >98% 56181-39-6 100g $799 2026-06-04 Buy
Activate Scientific AS12368 4-Chloro-5-bromopyrimidine 95% 56181-39-6 1g $32 2026-06-04 Buy
Product number Packaging Price Buy
OR902595 1g $21 Buy
OR902595 5g $45 Buy
OR902595 25g $202 Buy
OR902595 100g $799 Buy
AS12368 1g $32 Buy

4-Chloro-5-Bromopyrimidine Chemical Properties,Uses,Production

Chemical Properties

Pale yellow crystal

Synthesis

5-bromo-1H-pyrimidin-4-one

19808-30-1

4-Chloro-5-Bromopyrimidine

56181-39-6

The general procedure for the synthesis of 4-chloro-5-bromopyrimidine using 5-bromopyrimidin-4-one as starting material was as follows: to a mixture of 5-bromopyrimidin-4-ol (40 g, 0.22 mol) dissolved in POCl3 (300 mL) was added drop-wise DIPEA (29 g, 0.22 mol) at room temperature. Subsequently, the reaction mixture was heated to reflux and maintained for 3 hours. The progress of the reaction was monitored by TLC (unfolding agent ratio of petroleum ether/EtOAc 1:1) to confirm the completion of the reaction. Upon completion of the reaction, excess POCl3 was removed by distillation under reduced pressure. the residue was slowly poured into ice water (300 mL) under stirring. The aqueous phase was extracted with EtOAc (2 × 300 mL), the organic layers were combined and washed sequentially with water (300 mL) and brine (300 mL), dried over Na2SO4 and finally concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent ratio of petroleum ether/EtOAc, gradient from 20:1 to 10:1) to afford the target product 5-bromo-4-chloropyrimidine (25 g, 60% yield) as a yellow oil.

References

[1] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 88
[2] Patent: WO2012/135631, 2012, A1. Location in patent: Page/Page column 21-22
[3] Patent: WO2010/88518, 2010, A2. Location in patent: Page/Page column 86-87
[4] Organic Process Research and Development, 2000, vol. 4, # 4, p. 275 - 285

4-Chloro-5-Bromopyrimidine Preparation Products And Raw materials

Raw materials

5-bromo-1H-pyrimidin-4-one

Preparation Products

4-Chloro-5-Bromopyrimidine Suppliers

Global( 130)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14035 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14301 58
Dideu Industries Group Limited 		+8617392712697 1022@dideu.com China 29091 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49860 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Aladdin Scientific 		tp@aladdinsci.com United States 50108 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Win-Win chemical CO., Limited 		58
Dideu Industries Group Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58

View Lastest Price from 4-Chloro-5-Bromopyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-5-Bromopyrimidine pictures 2026-08-20 4-Chloro-5-Bromopyrimidine
56181-39-6
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
4-Chloro-5-Bromopyrimidine pictures 2020-03-16 4-Chloro-5-Bromopyrimidine
56181-39-6
 $3.00 1KG 98% 100KG Career Henan Chemical Co

4-Chloro-5-Bromopyrimidine Spectrum

4-Chloro-5-Bromopyrimidine(56181-39-6)1HNMR

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4-Chloro-5-Bromopyrimidine 4-Chloro-5-bromopyrimidin... Pyrimidine, 5-bromo-4-chloro- 4-Chloro-5-Bromopyrimidine ISO 9001：2015 REACH 56181-39-6 Heterocycle-Pyrimidine series