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5-Fluoro-2-nitrotoluene

5-Fluoro-2-nitrotoluene structure

CAS No.: 446-33-3

Chemical Name:: 5-Fluoro-2-nitrotoluene

Synonyms: 4-FLUORO-2-METHYL-1-NITROBENZENE;3-FLUORO-6-NITROTOLUENE;uoro-2-nitroto;uoro-2-nitrotoL;Fluoro-2-nitrotolu;Fluoronitrotoluene5;5-Fluoro-2-nitrotolu;5-FLUORO-2-NITROTOLUENE;5-Fluoro-2-nitrotoulene;2-NITRO-5-FLUORO TOLUENE

CBNumber:: CB1429466

Molecular Formula:: C7H6FNO2

Molecular Weight:: 155.13

MDL Number:: MFCD00007283

MOL File:: 446-33-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-28 09:47:34

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5-Fluoro-2-nitrotoluene Properties

Melting point	28°C
Boiling point	97-98 °C/10 mmHg (lit.)
Density	1.272 g/mL at 25 °C (lit.)
refractive index	n20/D 1.527(lit.)
Flash point	190 °F
storage temp.	Sealed in dry,Room Temperature
form	powder to lump to clear liquid
Specific Gravity	1.272
color	White or Colorless to Yellow
BRN	2046652
InChI	InChI=1S/C7H6FNO2/c1-5-4-6(8)2-3-7(5)9(10)11/h2-4H,1H3
InChIKey	JHFOWEGCZWLHNW-UHFFFAOYSA-N
SMILES	C1([N+]([O-])=O)=CC=C(F)C=C1C
CAS DataBase Reference	446-33-3(CAS DataBase Reference)
FDA UNII	DL37KMH6YZ
NIST Chemistry Reference	Benzene, 4-fluoro-2-methyl-1-nitro-(446-33-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS06

Signal word

Warning

Hazard statements

H302+H312+H332-H227-H302-H312-H331-H315-H319-H335

Precautionary statements

P305+P351+P338-P210e-P405-P501a-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36-45-37-28A

RIDADR

UN 2811

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29049085

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
1		0

5-Fluoro-2-nitrotoluene price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F12405	5-Fluoro-2-nitrotoluene 97%	446-33-3	50g	$264	2023-01-07	Buy
TCI Chemical	F0301	5-Fluoro-2-nitrotoluene >98.0%(GC)	446-33-3	5g	$31	2026-04-30	Buy
TCI Chemical	F0301	5-Fluoro-2-nitrotoluene >98.0%(GC)	446-33-3	25g	$121	2026-04-30	Buy
Usbiological	277803	5-Fluoro-2-nitrotoluene Asreported	446-33-3	250g	$393	2026-06-03	Buy
Usbiological	277803	5-Fluoro-2-nitrotoluene Asreported	446-33-3	500g	$602	2026-06-03	Buy

Product number	Packaging	Price	Buy
F12405	50g	$264	Buy
F0301	5g	$31	Buy
F0301	25g	$121	Buy
277803	250g	$393	Buy
277803	500g	$602	Buy

5-Fluoro-2-nitrotoluene Chemical Properties, Uses, Production

Chemical Properties

colorless to light yellow liquid

Uses

5-Fluoro-2-nitrotoluene can be used to synthesize 5-fluoro-2-nitrobenzaldehyde. The resulting substance can be used as an intermediate in pharmaceutical chemistry and organic synthesis to prepare herbicides, plant growth regulators, etc.

Industrial uses

5-Fluoro-2-nitrotoluene can be used to synthesize 5-fluoro-2-nitrobenzaldehyde, and the resulting substance can be used as an intermediate in pharmaceutical chemistry and organic synthesis, and can be used to prepare herbicides, plant growth regulators, etc.

Synthesis

352-70-5

446-33-3

The general procedure for the synthesis of 5-fluoro-2-nitrotoluene from 3-fluorotoluene is as follows: 1-fluoro-3-methylbenzene (9) (30 g, 273 mmol) was added slowly and dropwise to a stirred 90% aqueous nitric acid solution (100 mL) at 0-5 °C. The reaction mixture was stirred for 0.5 min and poured into ice water. The aqueous phase was extracted with dichloromethane (3 x 50 mL), the organic phases were combined and washed with saturated aqueous sodium bicarbonate (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution gradient: 0.5% to 3.3% ethyl acetate in petroleum ether) to afford the target product 5-fluoro-2-nitrotoluene as a yellow oil (16 g, 38% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 2.64 (s, 3H), 7.01-7.06 (m, 2H), 8.07 (m, 1H).

References

[1] Patent: US2010/324043, 2010, A1. Location in patent: Page/Page column 26-27
[2] Chemische Berichte, 1929, vol. 62, p. 1804
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[4] Journal of Organic Chemistry, 1961, vol. 26, p. 3351 - 3356
[5] Patent: US6020379, 2000, A

5-Fluoro-2-nitrotoluene Preparation Products And Raw materials

Raw materials

3-Fluorotoluene Nitric acid

Preparation Products

5-Fluoroindole-2-carboxylic acid 5-Fluoroindole 5-Fluoro-2-nitro benzylbromide 4-Fluoro-2-methylaniline 5-Fluoro-2-methylaniline

5-Fluoro-2-nitrobenzoic acid 5-Fluoroindole-3-carboxaldehyde 4-Bromo-5-fluoro-2-nitrotoluene 4-(3-Methyl-4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 4-(4-Chlorophenoxy)-2-methylaniline

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5-Fluoro-2-nitrotoluene Suppliers

Global Suppliers ( 356)

Supplier	Tel	Email	Country	ProdList	Advantage
FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID	15940530539 15396717197	361811402@qq.com	China	650	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Shandong Jiuyue Biological Technology Co. LT	18853316981	1214127295@qq.com	China	294	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Liaoning Tianhua Chemical Co., Ltd.	0418-6530555 2855550		China	338	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
Shandong Jiuyue Biological Technology Co. LT	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Liaoning Tianhua Chemical Co., Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from 5-Fluoro-2-nitrotoluene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	5-Fluoro-2-nitrotoluene 446-33-3	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2026-08-07	5-Fluoro-2-nitrotoluene 446-33-3	$1.00-28.00	1KG	99%	20000KG	Shaanxi Dideu Medichem Co. Ltd
2022-02-19	5-Fluoro-2-nitrotoluene 446-33-3		1KG	97.6%	100 tons	Honest Joy Holdings Limited

5-Fluoro-2-nitrotoluene
446-33-3
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

5-Fluoro-2-nitrotoluene
446-33-3
$1.00-28.00
99%
Shaanxi Dideu Medichem Co. Ltd

5-Fluoro-2-nitrotoluene
446-33-3
$0.00
97.6%
Honest Joy Holdings Limited

5-Fluoro-2-nitrotoluene Spectrum

5-Fluoro-2-nitrotoluene(446-33-3)MS 5-Fluoro-2-nitrotoluene(446-33-3)¹HNMR 5-Fluoro-2-nitrotoluene(446-33-3)¹³CNMR 5-Fluoro-2-nitrotoluene(446-33-3)IR1 5-Fluoro-2-nitrotoluene(446-33-3)Raman

446-33-3 (5-Fluoro-2-nitrotoluene ) Related Search:

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Nitrobenzene 2,4,6-Trinitrotoluene Methyl bromide Fluorine 5-Fluoro-2-nitrobenzadehyde

5-Fluoro-2-nitrobenzotrifluoride 5-Fluoro-2-nitrophenylacetonitrile 2,4-Dinitro-5-fluorotoluene

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3-FLUORO-6-NITROTOLUENE 2-Methyl-4-fluoronitrobenzene 3-Methyl-4-nitrofluorobenzene Toluene, 5-fluoro-2-nitro- Fluoronitrotoluene5 5-fluoro-2-nitrotoluenen 5-Fluoro-2-nitrotoluene, 98+% uoro-2-nitrotoL 5-Fluoro-2-nitrotoluene,96% 2-NITRO-5-FLUORO TOLUENE 5-FLUORO-2-NITROTOLUENE 4-FLUORO-2-METHYLNITROBENZENE Benzene,4-fluoro-2-methyl-1-nitro- 5-Fluoro-2-nitrotoluene 99% 5-Fluoro-2-nitrotoluene99% 1-Fluoro-3-methyl-4-nitrobenzene 1-Nitro-2-methyl-4-fluorobenzene 5-Fluoro-2-nitrotolu 5-Fluoro-2-nitrotoluene, 96% 10GR 5-Fluoro-2-nitrotoluene, 96% 50GR 4-Fluoro-2-methylnitrobenzene, 4-Fluoro-2-methyl-1-nitrobenzene 5-Fluoro-2-nitrotoulene Fluoro-2-nitrotolu 5-Fluoride-2-Nitrotoluene 5-Fluoro-2-nitrotoluene> 5-Fluoro-2-nitrotoluene 446-33-3 uoro-2-nitroto 4-FLUORO-2-METHYL-1-NITROBENZENE 446-33-3 Organic Building Blocks Nitrogen Compounds Nitro Compounds Building Blocks alkyl Fluorine| nitro-compound Fluorinated benzene series Aromatic Hydrocarbons (substituted) & Derivatives Halogen toluene Miscellaneous Nitro Compounds Nitrogen Compounds Organic Building Blocks