ChemicalBook >> CAS DataBase List >>5-Fluoro-2-nitrotoluene

5-Fluoro-2-nitrotoluene

5-Fluoro-2-nitrotoluene structure

CAS No.: 446-33-3

Chemical Name:: 5-Fluoro-2-nitrotoluene

Synonyms: 4-FLUORO-2-METHYL-1-NITROBENZENE;3-FLUORO-6-NITROTOLUENE;uoro-2-nitrotoL;Fluoro-2-nitrotolu;Fluoronitrotoluene5;5-Fluoro-2-nitrotolu;5-FLUORO-2-NITROTOLUENE;5-Fluoro-2-nitrotoulene;2-NITRO-5-FLUORO TOLUENE;5-fluoro-2-nitrotoluenen

CBNumber:: CB1429466

Molecular Formula:: C7H6FNO2

Molecular Weight:: 155.13

MDL Number:: MFCD00007283

MOL File:: 446-33-3.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:50

Product description	Number	Pack Size	Price
5-Fluoro-2-nitrotoluene 97%	F12405	50g	$264
5-Fluoro-2-nitrotoluene >98.0%(GC)	F0301	5g	$27
5-Fluoro-2-nitrotoluene >98.0%(GC)	F0301	25g	$105
4-Fluoro-2-methyl-1-nitrobenzene	F597103	500mg	$45
4-Fluoro-2-methyl-1-nitrobenzene	F597103	1g	$55
More product size

Request For Quotation

5-Fluoro-2-nitrotoluene Properties

Melting point	28°C
Boiling point	97-98 °C/10 mmHg (lit.)
Density	1.272 g/mL at 25 °C (lit.)
refractive index	n20/D 1.527(lit.)
Flash point	190 °F
storage temp.	Sealed in dry,Room Temperature
form	powder to lump to clear liquid
Specific Gravity	1.272
color	White or Colorless to Yellow
BRN	2046652
InChI	InChI=1S/C7H6FNO2/c1-5-4-6(8)2-3-7(5)9(10)11/h2-4H,1H3
InChIKey	JHFOWEGCZWLHNW-UHFFFAOYSA-N
SMILES	C1([N+]([O-])=O)=CC=C(F)C=C1C
CAS DataBase Reference	446-33-3(CAS DataBase Reference)
FDA UNII	DL37KMH6YZ
NIST Chemistry Reference	Benzene, 4-fluoro-2-methyl-1-nitro-(446-33-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS06

Signal word

Warning

Hazard statements

H302+H312+H332-H227-H302-H312-H331-H315-H319-H335

Precautionary statements

P305+P351+P338-P210e-P405-P501a-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36-45-37-28A

RIDADR

UN 2811

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29049085

NFPA 704

	2
1		0

5-Fluoro-2-nitrotoluene price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F12405	5-Fluoro-2-nitrotoluene 97%	446-33-3	50g	$264	2023-01-07	Buy
TCI Chemical	F0301	5-Fluoro-2-nitrotoluene >98.0%(GC)	446-33-3	5g	$27	2025-07-31	Buy
TCI Chemical	F0301	5-Fluoro-2-nitrotoluene >98.0%(GC)	446-33-3	25g	$105	2025-07-31	Buy
TRC	F597103	4-Fluoro-2-methyl-1-nitrobenzene	446-33-3	500mg	$45	2021-12-16	Buy
TRC	F597103	4-Fluoro-2-methyl-1-nitrobenzene	446-33-3	1g	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
F12405	50g	$264	Buy
F0301	5g	$27	Buy
F0301	25g	$105	Buy
F597103	500mg	$45	Buy
F597103	1g	$55	Buy

5-Fluoro-2-nitrotoluene Chemical Properties,Uses,Production

Chemical Properties

colorless to light yellow liquid

Industrial uses

5-Fluoro-2-nitrotoluene can be used to synthesize 5-fluoro-2-nitrobenzaldehyde, and the resulting substance can be used as an intermediate in pharmaceutical chemistry and organic synthesis, and can be used to prepare herbicides, plant growth regulators, etc.

Synthesis

352-70-5

446-33-3

The general procedure for the synthesis of 5-fluoro-2-nitrotoluene from 3-fluorotoluene is as follows: 1-fluoro-3-methylbenzene (9) (30 g, 273 mmol) was added slowly and dropwise to a stirred 90% aqueous nitric acid solution (100 mL) at 0-5 °C. The reaction mixture was stirred for 0.5 min and poured into ice water. The aqueous phase was extracted with dichloromethane (3 x 50 mL), the organic phases were combined and washed with saturated aqueous sodium bicarbonate (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution gradient: 0.5% to 3.3% ethyl acetate in petroleum ether) to afford the target product 5-fluoro-2-nitrotoluene as a yellow oil (16 g, 38% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 2.64 (s, 3H), 7.01-7.06 (m, 2H), 8.07 (m, 1H).

References

[1] Patent: US2010/324043, 2010, A1. Location in patent: Page/Page column 26-27
[2] Chemische Berichte, 1929, vol. 62, p. 1804
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[4] Journal of Organic Chemistry, 1961, vol. 26, p. 3351 - 3356
[5] Patent: US6020379, 2000, A

5-Fluoro-2-nitrotoluene Preparation Products And Raw materials

Raw materials

3-Fluorotoluene Nitric acid

Preparation Products

5-Fluoroindole-2-carboxylic acid 5-Fluoroindole 5-Fluoro-2-nitro benzylbromide 4-Fluoro-2-methylaniline 5-Fluoro-2-methylaniline

5-Fluoro-2-nitrobenzoic acid 5-FLUOROINDOLE-3-CARBOXALDEHYDE 4-Bromo-5-fluoro-2-nitrotoluene 4-(3-Methyl-4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 4-(4-CHLOROPHENOXY)-2-METHYLANILINE

1of2

5-Fluoro-2-nitrotoluene Suppliers

Global( 338)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3587	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20175	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	1348	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Shanghai Worldyang Chemical Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from 5-Fluoro-2-nitrotoluene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	5-Fluoro-2-nitrotoluene 446-33-3	US $200.00-1.00 / KG	1KG	99%, 99.5% Sublimated	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2024-07-29	5-Fluoro-2-nitrotoluene 446-33-3	US $1.00-28.00 / KG	1KG	99%	20000KG	Shaanxi Dideu Medichem Co. Ltd
2022-02-19	5-Fluoro-2-nitrotoluene 446-33-3	US $0.00 / KG	1KG	97.6%	100 tons	Honest Joy Holdings Limited

5-Fluoro-2-nitrotoluene
446-33-3
US $200.00-1.00 / KG
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

5-Fluoro-2-nitrotoluene
446-33-3
US $1.00-28.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

5-Fluoro-2-nitrotoluene
446-33-3
US $0.00 / KG
97.6%
Honest Joy Holdings Limited

5-Fluoro-2-nitrotoluene Spectrum

5-Fluoro-2-nitrotoluene(446-33-3)MS 5-Fluoro-2-nitrotoluene(446-33-3)¹HNMR 5-Fluoro-2-nitrotoluene(446-33-3)¹³CNMR 5-Fluoro-2-nitrotoluene(446-33-3)IR1 5-Fluoro-2-nitrotoluene(446-33-3)Raman

446-33-3(5-Fluoro-2-nitrotoluene )Related Search:

Bensulfuron methyl 3-Nitrotoluene Methylparaben 4-Nitrotoluene 2-Nitro-4-methylsulfonyltoluene

DINITROTOLUENE Kresoxim-methyl 2-Nitrotoluene Thiophanate-methyl Methyl

Nitrobenzene 2,4,6-Trinitrotoluene Methyl bromide Fluorine 5-Fluoro-2-nitrobenzotrifluoride

2,4-DINITRO-5-FLUOROTOLUENE 5-Fluoro-2-nitrobenzadehyde 5-FLUORO-2-NITROPHENYLACETONITRILE

1of4

3-FLUORO-6-NITROTOLUENE 2-Methyl-4-fluoronitrobenzene 3-Methyl-4-nitrofluorobenzene Toluene, 5-fluoro-2-nitro- Fluoronitrotoluene5 5-fluoro-2-nitrotoluenen 5-Fluoro-2-nitrotoluene, 98+% uoro-2-nitrotoL 5-Fluoro-2-nitrotoluene,96% 2-NITRO-5-FLUORO TOLUENE 5-FLUORO-2-NITROTOLUENE 4-FLUORO-2-METHYLNITROBENZENE 4-FLUORO-2-METHYL-1-NITROBENZENE Benzene,4-fluoro-2-methyl-1-nitro- 5-Fluoro-2-nitrotoluene 99% 5-Fluoro-2-nitrotoluene99% 1-Fluoro-3-methyl-4-nitrobenzene 1-Nitro-2-methyl-4-fluorobenzene 5-Fluoro-2-nitrotolu 5-Fluoro-2-nitrotoluene, 96% 10GR 5-Fluoro-2-nitrotoluene, 96% 50GR 4-Fluoro-2-methylnitrobenzene, 4-Fluoro-2-methyl-1-nitrobenzene 5-Fluoro-2-nitrotoulene Fluoro-2-nitrotolu 5-Fluoride-2-Nitrotoluene 5-Fluoro-2-nitrotoluene> 5-Fluoro-2-nitrotoluene 446-33-3 446-33-3 Organic Building Blocks Nitrogen Compounds Nitro Compounds Building Blocks alkyl Fluorine| nitro-compound Fluorinated benzene series Aromatic Hydrocarbons (substituted) & Derivatives Halogen toluene Miscellaneous Nitro Compounds Nitrogen Compounds Organic Building Blocks