5-Fluoroindole-3-carboxaldehyde
- CAS No.
- 2338-71-8
- Chemical Name:
- 5-Fluoroindole-3-carboxaldehyde
- Synonyms
- 5-FLUORO-1H-INDOLE-3-CARBALDEHYDE;120351;AKOS JY2083653;TIMTEC-BB SBB002930;5-Fluoro-3-formylindole;5-FLUOROINDOLE-3-ALDEHYDE;5-Fluoro-3-formyl-1H-indole;5-FLUOROINDOLE-3-CARBALDEHYDE;5-Fluoro-3-indolecarboxaldehyde;5-Fluoroindole-3-carboxaldehyde
- CBNumber:
- CB9393765
- Molecular Formula:
- C9H6FNO
- Molecular Weight:
- 163.15
- MDL Number:
- MFCD00022719
- MOL File:
- 2338-71-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 164°C |
|---|---|
| Boiling point | 342.4±22.0 °C(Predicted) |
| Density | 1.385±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| pka | 14.66±0.30(Predicted) |
| form | crystalline |
| color | yellow to green |
| Sensitive | Air Sensitive |
| BRN | 1449216 |
| InChI | 1S/C9H6FNO/c10-7-1-2-9-8(3-7)6(5-12)4-11-9/h1-5,11H |
| InChIKey | YUAJKGBLPVLADK-UHFFFAOYSA-N |
| SMILES | Fc1ccc2[nH]cc(C=O)c2c1 |
| CAS DataBase Reference | 2338-71-8(CAS DataBase Reference) |
| UNSPSC Code | 12352108 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Fluoroindole-3-carboxaldehyde price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F2001 | 5-Fluoroindole-3-carboxaldehyde ≥99%, crystalline | 2338-71-8 | 1g | $423 | 2023-06-20 | Buy |
| Biosynth | F-5100 | 5-Fluoroindole-3-carboxaldehyde | 2338-71-8 | 10g | $399.4 | 2026-06-04 | Buy |
| Biosynth | F-5100 | 5-Fluoroindole-3-carboxaldehyde | 2338-71-8 | 25g | $860.75 | 2026-06-04 | Buy |
| Biosynth | F-5100 | 5-Fluoroindole-3-carboxaldehyde | 2338-71-8 | 50g | $1583.5 | 2026-06-04 | Buy |
| Apolloscientific | PC9638 | 5-Fluoro-1H-indole-3-carboxaldehyde ≥95% | 2338-71-8 | 1g | $21 | 2026-06-04 | Buy |
5-Fluoroindole-3-carboxaldehyde Chemical Properties, Uses, Production
Uses
5-Fluoroindole-3-carboxaldehyde is used as a reagent in the synthetic preparation of compounds requiring an indole group or more specifically a fluoroindole group.
Synthesis
399-52-0
68-12-2
2338-71-8
GENERAL METHOD: Phosphoryl chloride (0.42 g, 2.74 mmol) was slowly added dropwise to a solution of N,N-dimethylformamide (0.84 g, 11.4 mmol) of 5-fluoroindole (0.30 g, 2.29 mmol) at 0 °C, the dropwise process lasted for 30 min. Subsequently, the reaction mixture was warmed up to 40 °C and kept for 1 hour. Upon completion of the reaction, ice was added to the reaction vessel followed by 2 M sodium hydroxide solution. The mixture was refluxed for 40 minutes. After the reaction solution was cooled to room temperature, it was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a mixed solvent of petroleum ether-ethyl acetate to give the target compound 5-fluoroindole-3-carboxaldehyde [19].
References
[1] Archiv der Pharmazie, 2017, vol. 350, # 1,
[2] Journal of the American Chemical Society, 2009, vol. 131, # 31, p. 10796 - 10797
[3] Marine Drugs, 2014, vol. 12, # 4, p. 1757 - 1772
[4] Patent: WO2015/90233, 2015, A1. Location in patent: Paragraph 00263
[5] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 344 - 367
5-Fluoroindole-3-carboxaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
View Latest Price from 5-Fluoroindole-3-carboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-06-02 | 5-Fluoroindole-3-carboxaldehyde in stock Factory
2338-71-8
|
$1.00 | 1KG | TOP 3 Factory in China | Chemwill Asia Co.,Ltd. | ||
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|
2020-06-02 | 5-Methoxyindole-3-cabroxaldehyde in stock Factory
2338-71-8
|
$1.00 | 1KG | TOP 3 Factory in China | Chemwill Asia Co.,Ltd. | ||
 |
2020-01-09 | 5-FLUOROINDOLE-3-CARBOXALDEHYDE
2338-71-8
|
$3.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- 5-Fluoroindole-3-carboxaldehyde in stock Factory
2338-71-8
- $1.00
- TOP 3 Factory in China
- Chemwill Asia Co.,Ltd.
-
- 5-Methoxyindole-3-cabroxaldehyde in stock Factory
2338-71-8
- $1.00
- TOP 3 Factory in China
- Chemwill Asia Co.,Ltd.
-
- 5-FLUOROINDOLE-3-CARBOXALDEHYDE
2338-71-8
- $3.00
- 98%
- Career Henan Chemical Co
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