5-FLUOROINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 2338-71-8
- Chemical Name:
- 5-FLUOROINDOLE-3-CARBOXALDEHYDE
- Synonyms
- 120351;AKOS JY2083653;TIMTEC-BB SBB002930;5-Fluoro-3-formylindole;5-FLUOROINDOLE-3-ALDEHYDE;5-Fluoro-3-formyl-1H-indole;5-FLUOROINDOLE-3-CARBALDEHYDE;5-Fluoro-3-indolecarboxaldehyde;5-FLUOROINDOLE-3-CARBOXALDEHYDE;5-FLUORO-1H-INDOLE-3-CARBALDEHYDE
- CBNumber:
- CB9393765
- Molecular Formula:
- C9H6FNO
- Molecular Weight:
- 163.15
- MDL Number:
- MFCD00022719
- MOL File:
- 2338-71-8.mol
- MSDS File:
- SDS
| Melting point | 164°C |
|---|---|
| Boiling point | 342.4±22.0 °C(Predicted) |
| Density | 1.385±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| pka | 14.66±0.30(Predicted) |
| form | crystalline |
| color | yellow to green |
| Sensitive | Air Sensitive |
| BRN | 1449216 |
| CAS DataBase Reference | 2338-71-8(CAS DataBase Reference) |
| UNSPSC Code | 12352108 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
5-FLUOROINDOLE-3-CARBOXALDEHYDE price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F2001 | 5-Fluoroindole-3-carboxaldehyde ≥99%, crystalline | 2338-71-8 | 1g | $423 | 2023-06-20 | Buy |
| TRC | F485795 | 5-Fluoroindole-3-carboxaldehyde | 2338-71-8 | 250mg | $45 | 2021-12-16 | Buy |
| Apolloscientific | PC9638 | 5-Fluoro-1H-indole-3-carboxaldehyde | 2338-71-8 | 1g | $26 | 2021-12-16 | Buy |
| Apolloscientific | PC9638 | 5-Fluoro-1H-indole-3-carboxaldehyde | 2338-71-8 | 5g | $101 | 2021-12-16 | Buy |
| Matrix Scientific | 064181 | 5-Fluoro-1H-indole-3-carbaldehyde | 2338-71-8 | 500mg | $119 | 2021-12-16 | Buy |
5-FLUOROINDOLE-3-CARBOXALDEHYDE Chemical Properties,Uses,Production
Uses
5-Fluoroindole-3-carboxaldehyde is used as a reagent in the synthetic preparation of compounds requiring an indole group or more specifically a fluoroindole group.
Synthesis
399-52-0
68-12-2
2338-71-8
GENERAL METHOD: Phosphoryl chloride (0.42 g, 2.74 mmol) was slowly added dropwise to a solution of N,N-dimethylformamide (0.84 g, 11.4 mmol) of 5-fluoroindole (0.30 g, 2.29 mmol) at 0 °C, the dropwise process lasted for 30 min. Subsequently, the reaction mixture was warmed up to 40 °C and kept for 1 hour. Upon completion of the reaction, ice was added to the reaction vessel followed by 2 M sodium hydroxide solution. The mixture was refluxed for 40 minutes. After the reaction solution was cooled to room temperature, it was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a mixed solvent of petroleum ether-ethyl acetate to give the target compound 5-fluoroindole-3-carboxaldehyde [19].
References
[1] Archiv der Pharmazie, 2017, vol. 350, # 1,
[2] Journal of the American Chemical Society, 2009, vol. 131, # 31, p. 10796 - 10797
[3] Marine Drugs, 2014, vol. 12, # 4, p. 1757 - 1772
[4] Patent: WO2015/90233, 2015, A1. Location in patent: Paragraph 00263
[5] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 344 - 367
5-FLUOROINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29802 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from 5-FLUOROINDOLE-3-CARBOXALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-06-02 | 5-Fluoroindole-3-carboxaldehyde in stock Factory
2338-71-8
|
US $1.00 / KG | 1KG | TOP 3 Factory in China | Top 3 largest production capacity Factory | Chemwill Asia Co.,Ltd. | |
|
|
2020-06-02 | 5-Methoxyindole-3-cabroxaldehyde in stock Factory
2338-71-8
|
US $1.00 / KG | 1KG | TOP 3 Factory in China | Top 3 largest production capacity Factory | Chemwill Asia Co.,Ltd. | |
 |
2020-01-09 | 5-FLUOROINDOLE-3-CARBOXALDEHYDE
2338-71-8
|
US $3.00 / KG | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- 5-Fluoroindole-3-carboxaldehyde in stock Factory
2338-71-8
- US $1.00 / KG
- TOP 3 Factory in China
- Chemwill Asia Co.,Ltd.
-
- 5-Methoxyindole-3-cabroxaldehyde in stock Factory
2338-71-8
- US $1.00 / KG
- TOP 3 Factory in China
- Chemwill Asia Co.,Ltd.
-
- 5-FLUOROINDOLE-3-CARBOXALDEHYDE
2338-71-8
- US $3.00 / KG
- 98%
- Career Henan Chemical Co
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