Losartan potassium

Losartan potassium Properties

Melting point	263-265°C
storage temp.	Inert atmosphere,Room Temperature
solubility	Freely soluble in water and in methanol, slightly soluble in acetonitrile.
form	powder or crystals
color	Off-white
Water Solubility	H2O: 2mg/mL, clear
Merck	14,5583
BRN	5845770
BCS Class	1
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI	InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
InChIKey	OXCMYAYHXIHQOA-UHFFFAOYSA-N
SMILES	C1(C=CC=CC=1C1=CC=C(CN2C(CO)=C(Cl)N=C2CCCC)C=C1)C1=NN=NN1[K]
CAS DataBase Reference	124750-99-8(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	Cozaar; losartan potassium
FDA UNII	3ST302B24A
NCI Drug Dictionary	Cozaar
UNSPSC Code	41116107
NACRES	NA.77

Pharmacokinetic data

Protein binding	>98%
Excreted unchanged in urine	4%
Volume of distribution	0.4(L/kg)
Biological half-life	1.5-2.5 (active metabolite 3- 9) / 4-6

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36/37/39

WGK Germany

3

RTECS

NI6755100

HS Code

2933290000

Storage Class

11 - Combustible Solids

NFPA 704

	0
4		0

Losartan potassium price More Price(101)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001062	Losartan potassium European Pharmacopoeia (EP) Reference Standard	124750-99-8	50 mg	$175	2026-04-30	Buy
Sigma-Aldrich	61188	Losartan potassium analytical standard	124750-99-8	100mg	$229	2026-04-30	Buy
Sigma-Aldrich	1370462	Losartan potassium United States Pharmacopeia (USP) Reference Standard	124750-99-8	150mg	$501	2026-04-30	Buy
TCI Chemical	L0232	Losartan Potassium >98.0%(HPLC)(T)	124750-99-8	5g	$152	2026-04-30	Buy
TCI Chemical	L0232	Losartan Potassium >98.0%(HPLC)(T)	124750-99-8	25g	$484	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0001062	50 mg	$175	Buy
61188	100mg	$229	Buy
1370462	150mg	$501	Buy
L0232	5g	$152	Buy
L0232	25g	$484	Buy

Losartan potassium Chemical Properties,Uses,Production

Description

As a angiotensin II receptor antagonist, Losartan Potassium is the potassium salt of losartan with antihypertensive activity, which is mainly used in the therapy of high blood pressure (hypertension) and diabetic nephropathy. It functions by relaxing blood vessels so that blood can flow more easily. It is also effective to help protect the kidneys from damage caused by diabetes and lower the risks of stroke in patients suffering from hypertension and myocardial enlargement. Besides, recent study has suggested that losartan is beneficial to reverse age related dysfunction in maintaining normal blood pressure and cellular energy usage on mitochondria and it can probably be used to treat left ventricular hypertrophy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.

References

https://en.wikipedia.org/wiki/Losartan
https://www.drugbank.ca/drugs/DB00678
https://pubchem.ncbi.nlm.nih.gov/compound/11751549#section=Top
http://www.medicinenet.com/losartan-oral/article.htm

Description

Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT₁) receptor. Losartan is an AT₁ receptor antagonist with a K_i value of 5-20 nM. It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats. In humans, losartan controls hypertension while protecting renal function.

Description

Losartan potassium is the first potent and selective non-peptide angiotensin II (AT II) AT₁ receptor antagonist introduced to the market as a once-daily oral antihypertensive. It is efficacious and long lasting in controlling blood pressure in spontaneous hypertensive rats, in patients with essential hypertension in addition to those patients with renal impairment. Since losartan functions by competitive antagonism at the level of receptor, which represents the most direct way of selectively inhibiting the renin-angiotensin system (RAS) independent of the source of AT II, its use has been reported to be free of the coughing side effect exhibited by the ACE inhibitors. In contrast to calcium channel blockers, losartan does not appear to cause ankle edema, headache and tachycardia. It is also reported to be in clinical trials for the treatment of heart failure. Other reports indicate that losartan may have potential efficacy as an anxiolytic, an antiglaucoma agent, in addition to in providing protection against stroke and in preventing the myointimal proliferative response of the vascular wall after coronary angioplasty and surgery.

Chemical Properties

White to Off-White Crystalline Powder

Originator

DuPont Merck (U.S.A.)

Uses

A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Uses

antihypertensive, AT1 angiotensin II antagonist

Uses

Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).

Manufacturing Process

2-Butyl-4-chloro-1-(2'-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5- methanolpotassium was synthesized in 5 stages.
1. Methyl 4'-methylbiphenyl-2-carboxylate (44.2 mmol), 0.5 N KOH in methanol (133 mmol), and water (50 mL) were mixed and refluxed under nitrogen. After 5 hours, the solvent was removed in vacuo and water (200 mL) and ethyl acetate (200 mL) added. The aqueous layer was acidified with concentrated hydrochloric acid to a pH of 3 and the layers were separated. The aqueous phase was extracted with ethyl acetate, the organic layers collected, dried (MgSO4) and the solvent removed in vacuo to yield 8.71 g of a 4'-methylbiphenyl-2-carboxylic acid, melting point 140.0-145.0°C.
2. 4'-Methylbiphenyl-2-carboxylic acid (41 mmol) and thionyl chloride (411 mmol) were mixed and refluxed for 2 hours. The excess thionyl chloride was removed in vacuo and the residue was taken up in toluene. The toluene was removed by rotary evaporation. The crude acid chloride was then added slowly to cold (0°C) concentrated NH4OH (50 mL) so that the temperature was kept below 15°C. After 15 minutes of stirring, water (100 mL) was added and solids precipitated. These were collected, washed with water and dried under high vacuum over P2O5 to yield 7.45 g of a white solid, melting point 126.0-128.5°C. The above product amide (35 mmol) and thionyl chloride (353 mmol) were mixed and refluxed for 3 hours. The thionyl chloride was removed using the same procedure as described above. The residue was washed with a little hexane to yield 6.64 g of 4'-methyl-2-cyanobiphenyl, melting point 44.0- 47.0°C.
3. 4'-Methyl-2-cyanobiphenyl (5.59 g) was brominated using benzoyl peroxide as an initiator. The product was recrystallized from ether to yield 4.7 g of 4'- bromomethyl-2-cyanobiphenyl, melting point 114.5-120.0°C.
4. 4'-Bromomethyl-2-cyanobiphenyl (4.6 g) was alkylated onto 2-n-butyl-4- chloro-5-(hydroxymethyl)-imidazole. For separation of the product was used a flash chromatography in 1:1 hexane/ethyl acetate over silica gel. The regioisomeric products yielded 2.53 g of the faster eluting isomer. Recrystallization from acetonitrile yielded 1.57 g of analytically pure 2-n-butyl4-chloro-1-[2'-cyanobiphenyl-4-yl)methyl]-5-(hydroxymethyl)-imidazole, melting point 153.5 -155.5°C.
5. 2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)- imidazole (10 mmole), sodium azide (10 mmol), and ammonium chloride (30 mmol) were mixed in DMF (150 mL) under N2 at 100°C for 2 days, after which the temperature was raised to 120°C for 6 days. The reaction was cooled and 3 more equivalents each of ammonium chloride and sodium azide were added. The reaction was again heated for 5 days at 120°C. The reaction was cooled, the inorganic salts filtered, and the filtrate solvent removed in vacuo. Water (200 mL) and ethyl acetate (200 mL) were added to the residue and the layers were separated. The aqueous layer was extracted with ethyl acetate, the organic layers were collected, dried (MgSO4) and the solvent removed in vacuo, to yield a dark yellow oil. The product was purified by flash chromatography in 100% ethyl acetate to 100% ethanol over silica gel to yield 5.60 g of a light yellow 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1Htetrazol-5-yl)biphenyl-4-yl)methyl]imidazole. Recrystallization from acetonitrile yielded 4.36 g of light yellow crystals which still melted broadly. The crystals were taken up in 100 mL of hot acetonitrile. The solid that did not dissolve was filtered off to yield 1.04 g of product as a light yellow solid, melting point of 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]imidazole 183.5-184.5°C.
2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]imidazole may be converted to potassium salt.

brand name

Cozaar (Merck).

Therapeutic Function

Antihypertensive

Biological Activity

Selective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.

storage

RT (desiccate)

Background

Losartan is a known angiotensin II receptor antagonist by selectively and competitively blocking the binding of the angiotensin II hormone. In clinical settings, it is useful as an antihypertensive agent and also displays neuroprotective effects against chronic fatigue stress. Losartan inhibits collagen I synthesis and induces sirtuin 1 expression and activity.

References

[1]
[2] A T CHIU. Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent.[J]. Journal of Pharmacology and Experimental Therapeutics, 1990, 252 2: 711-718.
[3] M. MCINTYRE . Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of its efficacy and safety in essential hypertension[J]. Pharmacology & Therapeutics, 1997, 74 2: Pages 181-194. DOI:10.1016/s0163-7258(97)82002-5
[4] BENJAMIN DIOP-FRIMPONG. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 7: 2909-2914. DOI:10.1073/pnas.1018892108
[5] EIRINI PANTAZI. Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation.[J]. World Journal of Gastroenterology, 2015, 21 26: 8021-8031. DOI:10.3748/wjg.v21.i26.8021
[6] ANIL KUMAR. Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress.[J]. Inflammopharmacology, 2015, 23 6: 291-305. DOI:10.1007/s10787-015-0238-z
[7] J. L. MIGUEL-CARRASCO. Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites[J]. Scientific Reports, 2017. DOI:10.1038/srep41865

Losartan potassium synthesis

Synthesis of Losartan potassium from Losartan

Losartan potassium Preparation Products And Raw materials

Raw materials

Thionyl chloride 4′-Methylbiphenyl-2-carboxylic acid methyl ester 2-n-Butyl-4-Chloro-5-Hydroxymethyl Imidazole Potassium hydroxide Sodium azide

Ammonium hydroxide Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde Losartan 2-Butyl-4-chloro-5-formylimidazole 4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile

4-Bromomethyl-2-cyanobiphenyl

1of3

Preparation Products

N-Trityl Losartan Carboxylic Acid

Losartan potassium Suppliers

Global( 947)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou TongYi biochemistry technology Co.,LTD		tongyibiochem@163.com	China	2995	58
Sinoway Industrial co., ltd.	+86-0592-5800732 +86-13806035118	xie@china-sinoway.com	China	1369	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5998	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Anhui Ruihan Technology Co., Ltd	+undefined17756083858	daisy@anhuiruihan.com	China	973	58
Shaanxi TNJONE Pharmaceutical Co., Ltd		sarah@tnjone.com	China	1143	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +86-17709210191	Jerry@xhobio.com	China	906	58
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	672	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8618017249410	jack.li@time-chemicals.com	China	1803	55

Supplier	Advantage
Guangzhou TongYi biochemistry technology Co.,LTD	58
Sinoway Industrial co., ltd.	58
Wuhan Fortuna Chemical Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Anhui Ruihan Technology Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Shaanxi Xianhe Biotech Co., Ltd	58
Wuhan JiyunZen Tech Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55

View Lastest Price from Losartan potassium manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-31	Losartan Potassium 124750-99-8	1KG	USP	20tons	Sinoway Industrial co., ltd.
2026-07-31	Losartan potassium 124750-99-8	25kg	98.5%~101.0%; USP42	7000kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-30	Losartan potassium 124750-99-8		0.99		RongNa Biotechnology Co.,Ltd

Losartan Potassium
124750-99-8
USP
Sinoway Industrial co., ltd.

Losartan potassium
124750-99-8
98.5%~101.0%; USP42
WUHAN FORTUNA CHEMICAL CO., LTD

Losartan potassium
124750-99-8
0.99
RongNa Biotechnology Co.,Ltd

Losartan potassium Spectrum

Losartan potassium(124750-99-8)¹HNMR

124750-99-8(Losartan potassium)Related Search:

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Thiophanate-methyl Potassium chloride Methyl

1of4

2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL 2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt 2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT LOSARTAN MONOPOTASSIUM SALT LOSARTAN POTASSIUM LOSARTAN POTASSIUM SALT MK 954 1h-imidazole-5-methanol,2-butyl-4-chloro-1-((2’-(1h-tetrazol-5-yl)(1,1’-biphe 2-butyl-4-chloro-1-(2’-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1h-imidazole-5-me Losartan Potassium (250 mg) 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-iMidaz Losartan potassiuM API 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt Losartan PotassiuM/Losartan K COZAAR DUP 753 Losartan PotassiuM (DuP 753) 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, potassium salt (1:1) Losartan Potassium (150 mg) potassium (1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanolate potassium (2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanolate potassium [2-butyl-5-chloro-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]met potassium [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolyl]methanolate potassium [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanolate potassium [2-butyl-5-chloro-3-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]imidazol-4-yl]methanolate Losartan potassium Joyce [2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]-4-imidazolyl]methanol DuP-753 potassium dupont753 l-158086 mk-0954 thanolpotassium 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-imidazole-5-methanol,monopotassium salt MK-95 LOSARTANPOTASSIUM(SUBJECTTOPATENTFREE) 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'- Aradois 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanolpotassiumsalt Potassium (2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)me Potassium chloride sha Tanzania Losartan potassium 124750-99-8 Losartan potassium Solution, 100ppm Potassium 2-Butyl-4-chloro-[1-[[2'-(5-tetrazolyl)biphenyl-4-yl]methyl]-5-imidazolyl]methanolate Losartan potassium CRS LosartanPotassium> Losartan Potassium RS (1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol, potassium salt Losartan potassium USP/EP/BP Losartan Potassium- IP/USP Losartan potassium (Y0001062) Losartan potassiumQ: What is Losartan potassium Q: What is the CAS Number of Losartan potassium Q: What is the storage condition of Losartan potassium Q: What are the applications of Losartan potassium Losartan Potassium (1370462) Chlorine sand potassium COZAAR Powder USP Standard Losartan Potassium IP/BP/Ph. Eur /USP Losartan Potassium 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4- yl]methyl]-1H-imidazole-5-methanol monopotassium salt Losartan Potassium / Losartan MonoPotassium Salt 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, potassium salt (1:1)

Product description	Number	Pack Size	Price
Losartan potassium European Pharmacopoeia (EP) Reference Standard	Y0001062	50 mg	$175
Losartan potassium analytical standard	61188	100mg	$229
Losartan potassium United States Pharmacopeia (USP) Reference Standard	1370462	150mg	$501
Losartan Potassium >98.0%(HPLC)(T)	L0232	5g	$152
Losartan Potassium >98.0%(HPLC)(T)	L0232	25g	$484
More product size

Losartan potassium Properties

Pharmacokinetic data

SAFETY

Risk and Safety Statements

Losartan potassium price More Price(101)

Losartan potassium Chemical Properties,Uses,Production

Description

References

Description

Description

Chemical Properties

Originator

Uses

Uses

Uses

Manufacturing Process

brand name

Therapeutic Function

Biological Activity

storage

Background

References

Losartan potassium synthesis

Losartan potassium Preparation Products And Raw materials

Raw materials

Preparation Products

Losartan potassium Suppliers

Related articles

View Lastest Price from Losartan potassium manufacturers

Losartan potassium Spectrum

124750-99-8(Losartan potassium)Related Search: