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Losartan

Losartan structure

CAS No.: 114798-26-4

Chemical Name:: Losartan

Synonyms: LOS;dup89;LOSARTAN;Compound 89;Losartan（base）;Losartan (DUP 89);nyl)-4-yl)methyl)-;Losartan (DuP-753);Losartan USP/EP/BP;Losartan - Bio-X ?

CBNumber:: CB8120081

Molecular Formula:: C22H23ClN6O

Molecular Weight:: 422.91

MDL Number:: MFCD00865831

MOL File:: 114798-26-4.mol

MSDS File:: SDS

Last updated:2025-10-14 17:34:16

Product description	Number	Pack Size	Price
Losartan ≥98% (HPLC)	SML3317	10 mg	$93.8
Losartan ≥98% (HPLC)	SML3317	50 mg	$359.1
Losartan	L0378	5G	$80
Losartan	L0378	25G	$241
Losartan	L470470	500mg	$385
More product size

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Losartan Properties

Melting point	183-184 C
Boiling point	682.0±65.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
vapor pressure	0.002Pa at 20℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	5-6(at 25℃)
color	White to Off-White
Water Solubility	4.8mg/L at 20℃
LogP	1.1 at 20℃
CAS DataBase Reference	114798-26-4(CAS DataBase Reference)
FDA UNII	JMS50MPO89
ATC code	C09CA01
EPA Substance Registry System	1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (114798-26-4)
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H317-H360FD-H362
Precautionary statements	P202-P260-P263-P280-P302+P352-P308+P313
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
Hazardous Substances Data	114798-26-4(Hazardous Substances Data)

Losartan price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3317	Losartan ≥98% (HPLC)	114798-26-4	10 mg	$93.8	2025-07-31	Buy
Sigma-Aldrich	SML3317	Losartan ≥98% (HPLC)	114798-26-4	50 mg	$359.1	2025-07-31	Buy
TCI Chemical	L0378	Losartan	114798-26-4	5G	$80	2025-07-31	Buy
TCI Chemical	L0378	Losartan	114798-26-4	25G	$241	2025-07-31	Buy
TRC	L470470	Losartan	114798-26-4	500mg	$385	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML3317	10 mg	$93.8	Buy
SML3317	50 mg	$359.1	Buy
L0378	5G	$80	Buy
L0378	25G	$241	Buy
L470470	500mg	$385	Buy

Losartan Chemical Properties,Uses,Production

Originator

Alsartan, Aristo Pharmaceutical Ltd., India

Uses

Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Uses

antihypertensive;antagonist of angiotensin type 1

Definition

ChEBI: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Manufacturing Process

2-Butyl-4-chloro-1-(2'-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5- methanolpotassium was synthesized in 5 stages.
1. Methyl 4'-methylbiphenyl-2-carboxylate (44.2 mmol), 0.5 N KOH in methanol (133 mmol), and water (50 mL) were mixed and refluxed under nitrogen. After 5 hours, the solvent was removed in vacuo and water (200 mL) and ethyl acetate (200 mL) added. The aqueous layer was acidified with concentrated hydrochloric acid to a pH of 3 and the layers were separated. The aqueous phase was extracted with ethyl acetate, the organic layers collected, dried (MgSO4) and the solvent removed in vacuo to yield 8.71 g of a 4'-methylbiphenyl-2-carboxylic acid, melting point 140.0-145.0°C.
2. 4'-Methylbiphenyl-2-carboxylic acid (41 mmol) and thionyl chloride (411 mmol) were mixed and refluxed for 2 hours. The excess thionyl chloride was removed in vacuo and the residue was taken up in toluene. The toluene was removed by rotary evaporation. The crude acid chloride was then added slowly to cold (0°C) concentrated NH4OH (50 mL) so that the temperature was kept below 15°C. After 15 minutes of stirring, water (100 mL) was added and solids precipitated. These were collected, washed with water and dried under high vacuum over P2O5 to yield 7.45 g of a white solid, melting point 126.0-128.5°C. The above product amide (35 mmol) and thionyl chloride (353 mmol) were mixed and refluxed for 3 hours. The thionyl chloride was removed using the same procedure as described above. The residue was washed with a little hexane to yield 6.64 g of 4'-methyl-2-cyanobiphenyl, melting point 44.0- 47.0°C.
3. 4'-Methyl-2-cyanobiphenyl (5.59 g) was brominated using benzoyl peroxide as an initiator. The product was recrystallized from ether to yield 4.7 g of 4'- bromomethyl-2-cyanobiphenyl, melting point 114.5-120.0°C.
4. 4'-Bromomethyl-2-cyanobiphenyl (4.6 g) was alkylated onto 2-n-butyl-4- chloro-5-(hydroxymethyl)-imidazole. For separation of the product was used a flash chromatography in 1:1 hexane/ethyl acetate over silica gel. The regioisomeric products yielded 2.53 g of the faster eluting isomer. Recrystallization from acetonitrile yielded 1.57 g of analytically pure 2-n-butyl4-chloro-1-[2'-cyanobiphenyl-4-yl)methyl]-5-(hydroxymethyl)-imidazole, melting point 153.5 -155.5°C.
5. 2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)- imidazole (10 mmole), sodium azide (10 mmol), and ammonium chloride (30 mmol) were mixed in DMF (150 mL) under N2 at 100°C for 2 days, after which the temperature was raised to 120°C for 6 days. The reaction was cooled and 3 more equivalents each of ammonium chloride and sodium azide were added. The reaction was again heated for 5 days at 120°C. The reaction was cooled, the inorganic salts filtered, and the filtrate solvent removed in vacuo. Water (200 mL) and ethyl acetate (200 mL) were added to the residue and the layers were separated. The aqueous layer was extracted with ethyl acetate, the organic layers were collected, dried (MgSO4) and the solvent removed in vacuo, to yield a dark yellow oil. The product was purified by flash chromatography in 100% ethyl acetate to 100% ethanol over silica gel to yield 5.60 g of a light yellow 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1Htetrazol-5-yl)biphenyl-4-yl)methyl]imidazole. Recrystallization from acetonitrile yielded 4.36 g of light yellow crystals which still melted broadly. The crystals were taken up in 100 mL of hot acetonitrile. The solid that did not dissolve was filtered off to yield 1.04 g of product as a light yellow solid, melting point of 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]imidazole 183.5-184.5°C.
2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]imidazole may be converted to potassium salt.

brand name

Cozaar (Merck).

Therapeutic Function

Antihypertensive

General Description

Losartan, 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-yl-phenyl)benzyl]imidazole-5-methanol monopotassiumsalt (Cozarr), was the first nonpeptide imidazole to beintroduced as an orally active angiotensin II antagonist withhigh specificity for AT1. When administered to patients, itundergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid. This metabolismis mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potentthan the parent hydroxyl compound. Because the parent hydroxylcompound has affinity for the AT1 receptor, strictlyspeaking, it is not a prodrug.

Flammability and Explosibility

Non flammable

Biological Activity

Losartan is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan is used for treatment of hypertension.

Losartan Preparation Products And Raw materials

Raw materials

1-Methylimidazole Sodium azide Losartan carboxylic acid Methanol solution of sodium methoxide 2-n-Butyl-4-Chloro-5-Hydroxymethyl Imidazole

4′-Methylbiphenyl-2-carboxylic acid methyl ester Thionyl chloride Ammonium hydroxide Potassium hydroxide

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Preparation Products

METHYL TRIPHENYLMETHYL ETHER Losartan potassium

Losartan Suppliers

Global( 308)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12247	58
Sinoway Industrial co., ltd.	+86-0592-5800732 +86-13806035118	xie@china-sinoway.com	China	1113	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3965	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Sinoway Industrial co., ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from Losartan manufacturers

Update time	Product	Price	Purity	Supply Ability	Manufacturer
2025-10-15	Losartan 114798-26-4		0.99		RongNa Biotechnology Co.,Ltd
2025-10-15	Losartan 114798-26-4	US $50.00 / g	99.64%	10g	TargetMol Chemicals Inc.
2025-10-15	Losartan 114798-26-4	US $50.00 / g	99.64%	10g	TargetMol Chemicals Inc.

Losartan
114798-26-4
0.99
RongNa Biotechnology Co.,Ltd

Losartan
114798-26-4
US $50.00 / g
99.64%
TargetMol Chemicals Inc.

Losartan
114798-26-4
US $50.00 / g
99.64%
TargetMol Chemicals Inc.

Losartan Spectrum

Losartan(114798-26-4)¹HNMR

114798-26-4(Losartan)Related Search:

1H-Tetrazole-1-acetic acid Imidazole Methanol Nitrotetrazolium blue chloride Benzyl benzoate

Benzyl alcohol Benzyl nicotinate Tetrazole 2,3,5-Triphenyltetrazolium chloride Benzyl chloride

Benzyl isocyanate Bifendate LOSARTAN MONOPOTASSIUM SALT,LOSARTAN POTASSIUM SALT,LOSARTAN POTASSIUM Difluorochloromethane TRIPHENYL LOSARTAN,Trithyl Losartan,TRITYL LOSARTAN

Benzyl Losartan carboxylic acid NO-LOSARTAN A

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dup89 LOS nyl)-4-yl)methyl)- 2-butyl-4-chloro-1-[p-(o-1h-tetrazol-5-ylphenyl)benzyl]imidazole-5- methanol LOSARTAN LosartanC22H23C1N60 1h-imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1h-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)- (1-((2-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL)METHYL)-2-BUTYL-4-CHLORO-1H-IMIDAZOL-5-YL)METHANOL (LOSARTAN) 2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-y1)[1，1'-biphenyl]’4’y1]methyl]-1H-imidazole-5-methanol 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-5-chloro-3H-imidazole-4-methanol 2-Butyl-4-chloro-5-(hydroxymethyl)-1-[(2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole Compound 89 2-n-butyl-4-chloro-5-hydroxyMethyl-1-[(2'-(1H-tetrazole-5-yl)biph 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-1H-imidazol-5-methanol (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol (2-BUTYL-4-CHLORO-1-{[2'-(1H-TETRAZOL-5-YL)-4-BIPHENYLYL]METHYL}-1H-IMIDAZOL-5-YL)METHANOL Losartan (DuP-753) [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolyl]methanol 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- Losartan Potassium Form-I Losartan USP/EP/BP 2-Butyl-4-chloro-1[[(2'-(1 H-tetrazole-5-yl) (1,1'-biphenyl)-4yl]methyl]-1H imidazole-5-methanol (Losartan) Losartan (DUP 89) LosartanQ: What is Losartan Q: What is the CAS Number of Losartan Q: What is the storage condition of Losartan Q: What are the applications of Losartan Benzaldehyde,3,4-dichloro-6-hydroxy- (3-oxo-1lambda3,2-benziodoxol-5-yl)acetate Losartan（base） 2 butyl 4-chloro-1[(2-(1H-tetrazole-5[1,1 biphenyl]-4-yl]methyl]-H imidazole-5methanol (1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol Losartan in methanol (1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol Losartan, 10 mM in DMSO 2-Butyl-4-Chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol Losartan - Bio-X ? Losartan potassium intermediate 114798-26-4 C22H23ClN6O Isotopically Labeled Pharmaceutical Reference Standard