4-(4-n-Butylphenyl)benzoic acid
- CAS No.
- 59662-46-3
- Chemical Name:
- 4-(4-n-Butylphenyl)benzoic acid
- Synonyms
- 4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid;RARECHEM AL BO 0889;4-Butylbibenzoic acid;4-Butyl-4''-carboxybiphenyl;4-(4-butylphenyl)benzoic acid;4-(4-n-Butylphenyl)benzoic acid;-butylbiphenyl-4-carboxylic acid;4'-Butylbiphenyl-4-carboxylic acid;4'-Butylbiphenyl-4-carboxylic acid;4-BUTYL-4'-BIPHENYLCARBOXYLIC ACID
- CBNumber:
- CB1446643
- Molecular Formula:
- C17H18O2
- Molecular Weight:
- 254.32
- MDL Number:
- MFCD00222812
- MOL File:
- 59662-46-3.mol
- MSDS File:
- SDS
| Boiling point | 413.5±34.0 °C(Predicted) |
|---|---|
| Density | 1.091±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.22±0.10(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 59662-46-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
4-(4-n-Butylphenyl)benzoic acid price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS48583 | 4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid 98% | 59662-46-3 | 1g | $40 | 2026-06-04 | Buy |
| Activate Scientific | AS48583 | 4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid 98% | 59662-46-3 | 5g | $126 | 2026-06-04 | Buy |
| Activate Scientific | AS48583 | 4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid 98% | 59662-46-3 | 25g | $370 | 2026-06-04 | Buy |
| Synthonix | B58964 | 4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid 98% | 59662-46-3 | 250mg | $81 | 2026-05-06 | Buy |
| Synthonix | B58964 | 4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid 98% | 59662-46-3 | 1g | $87 | 2026-05-06 | Buy |
4-(4-n-Butylphenyl)benzoic acid Chemical Properties, Uses, Production
Uses
4''-Butylbiphenyl-4-carboxylic Acid is an intermediate used in the preparation of biphenylcarboxylates used as RARβ2 receptor agonist.
Synthesis
![[1,1'-Biphenyl]-4-carboxylic acid, 4'-butyl-, methyl ester](/CAS/20210305/GIF/1451206-56-6.gif)
1451206-56-6
59662-46-3
General Method 13: Synthesis of biaryl or aryl-heteroaryl carboxylic acids from 1-bromo-4-butylbenzene and arylboronic or heteroarylboronic acids by Suzuki coupling reaction. This method is specifically applied to the synthesis of 4-n-butylbiphenyl-4'-carboxylic acids. A mixture of methyl 4-(4-butylphenyl)benzoate (89.0 g, 0.332 mol) and NaOH (26.6 g, 0.664 mol) in THF/H2O (500 mL/100 mL) mixed solvent was heated to reflux and reacted overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, THF was removed by distillation under reduced pressure.The residue was acidified to pH 3-4 with 2N HCl solution.The resulting mixture was filtered and the filter cake was washed with deionized water and dried to give 4-(4-butylphenyl)benzoic acid (60.0 g, yield: 71.1%) as white solid. The mass spectrum (ESI) showed m/z 255.0 ([M+H]+).
References
[1] Patent: WO2013/123456, 2013, A1. Location in patent: Paragraph 00269; 00271
[2] Patent: WO2017/84629, 2017, A1. Location in patent: Paragraph 00341
[3] Patent: WO2017/84630, 2017, A1. Location in patent: Paragraph 00444
[4] Patent: US2013/217619, 2013, A1. Location in patent: Page/Page column
4-(4-n-Butylphenyl)benzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2284 | 55 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| CHMA Chemical Technology (Shanghai) Co., Ltd | 021-61556450 15800904410 | China | 2827 | 58 | |
| Nanjing Abix Biochemical Technology Co., Ltd. | 025-87193546 18652950785; | chemweiao@163.com | China | 9009 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Suzhou chems bio-tech.co.,Ltd. | 0512-67903504 13814824891;13814824891 | 604360797@qq.com | China | 410 | 58 |
View Latest Price from 4-(4-n-Butylphenyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-(4-n-butylphenyl)benzoic acid
59662-46-3
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2023-04-06 | 4-(4-N-BUTYLPHENYL)BENZOIC ACID
59662-46-3
|
1kg | 98.0% | 1000kg | LY Global chemicals co.,ltd . | ||
 |
2019-08-27 | 4-(4-N-BUTYLPHENYL)BENZOIC ACID
59662-46-3
|
$3.00 | 3KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- 4-(4-n-butylphenyl)benzoic acid
59662-46-3
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 4-(4-N-BUTYLPHENYL)BENZOIC ACID
59662-46-3
- 98.0%
- LY Global chemicals co.,ltd .
-
- 4-(4-N-BUTYLPHENYL)BENZOIC ACID
59662-46-3
- $3.00
- 98%
- Career Henan Chemical Co
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