4-(4-N-BUTYLPHENYL)BENZOIC ACID
- CAS No.
- 59662-46-3
- Chemical Name:
- 4-(4-N-BUTYLPHENYL)BENZOIC ACID
- Synonyms
- RARECHEM AL BO 0889;4-Butylbibenzoic acid;4-Butyl-4''-carboxybiphenyl;4-(4-butylphenyl)benzoic acid;4-(4-N-BUTYLPHENYL)BENZOIC ACID;4'-Butylbiphenyl-4-carboxylic acid;4-BUTYL-4'-BIPHENYLCARBOXYLIC ACID;4'-Butylbiphenyl-4-carboxylic acid;4-N-BUTYLBIPHENYL-4'-CARBOXYLIC ACID;4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid
- CBNumber:
- CB1446643
- Molecular Formula:
- C17H18O2
- Molecular Weight:
- 254.32
- MDL Number:
- MFCD00222812
- MOL File:
- 59662-46-3.mol
| Boiling point | 413.5±34.0 °C(Predicted) |
|---|---|
| Density | 1.091±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.22±0.10(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 59662-46-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
4-(4-N-BUTYLPHENYL)BENZOIC ACID price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B809763 | 4''-Butylbiphenyl-4-carboxylicAcid | 59662-46-3 | 100mg | $60 | 2021-12-16 | Buy |
| AK Scientific | 8880AB | 4'-Butyl-[1,1'-biphenyl]-4-carboxylicacid | 59662-46-3 | 1g | $91 | 2021-12-16 | Buy |
| ChemScene | CS-W022126 | 4'-Butyl-[1,1'-biphenyl]-4-carboxylicacid >97.0% | 59662-46-3 | 5g | $92 | 2021-12-16 | Buy |
| ChemScene | CS-W022126 | 4'-Butyl-[1,1'-biphenyl]-4-carboxylicacid >97.0% | 59662-46-3 | 10g | $146 | 2021-12-16 | Buy |
| AK Scientific | 8880AB | 4'-Butyl-[1,1'-biphenyl]-4-carboxylicacid | 59662-46-3 | 5g | $172 | 2021-12-16 | Buy |
4-(4-N-BUTYLPHENYL)BENZOIC ACID Chemical Properties,Uses,Production
Uses
4''-Butylbiphenyl-4-carboxylic Acid is an intermediate used in the preparation of biphenylcarboxylates used as RARβ2 receptor agonist.
Synthesis
![[1,1'-Biphenyl]-4-carboxylic acid, 4'-butyl-, methyl ester](/CAS/20210305/GIF/1451206-56-6.gif)
1451206-56-6
59662-46-3
General Method 13: Synthesis of biaryl or aryl-heteroaryl carboxylic acids from 1-bromo-4-butylbenzene and arylboronic or heteroarylboronic acids by Suzuki coupling reaction. This method is specifically applied to the synthesis of 4-n-butylbiphenyl-4'-carboxylic acids. A mixture of methyl 4-(4-butylphenyl)benzoate (89.0 g, 0.332 mol) and NaOH (26.6 g, 0.664 mol) in THF/H2O (500 mL/100 mL) mixed solvent was heated to reflux and reacted overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, THF was removed by distillation under reduced pressure.The residue was acidified to pH 3-4 with 2N HCl solution.The resulting mixture was filtered and the filter cake was washed with deionized water and dried to give 4-(4-butylphenyl)benzoic acid (60.0 g, yield: 71.1%) as white solid. The mass spectrum (ESI) showed m/z 255.0 ([M+H]+).
References
[1] Patent: WO2013/123456, 2013, A1. Location in patent: Paragraph 00269; 00271
[2] Patent: WO2017/84629, 2017, A1. Location in patent: Paragraph 00341
[3] Patent: WO2017/84630, 2017, A1. Location in patent: Paragraph 00444
[4] Patent: US2013/217619, 2013, A1. Location in patent: Page/Page column
4-(4-N-BUTYLPHENYL)BENZOIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20202 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12878 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 21526 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
View Lastest Price from 4-(4-N-BUTYLPHENYL)BENZOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-02 | 4-(4-n-butylphenyl)benzoic acid
59662-46-3
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-04-06 | 4-(4-N-BUTYLPHENYL)BENZOIC ACID
59662-46-3
|
US $0.00-0.00 / kg | 1kg | 98.0% | 1000kg | LY Global chemicals co.,ltd . | |
 |
2019-08-27 | 4-(4-N-BUTYLPHENYL)BENZOIC ACID
59662-46-3
|
US $3.00 / KG | 3KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- 4-(4-n-butylphenyl)benzoic acid
59662-46-3
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 4-(4-N-BUTYLPHENYL)BENZOIC ACID
59662-46-3
- US $0.00-0.00 / kg
- 98.0%
- LY Global chemicals co.,ltd .
-
- 4-(4-N-BUTYLPHENYL)BENZOIC ACID
59662-46-3
- US $3.00 / KG
- 98%
- Career Henan Chemical Co
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