4-Nitro-o-phenylenediamine

4-Nitro-o-phenylenediamine Properties

Melting point	199-201 °C (lit.)
Boiling point	276.04°C (rough estimate)
Density	1.3682 (rough estimate)
refractive index	1.6910 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	1 N HCl: ethanol, 1:1: soluble50mg/mL
form	Powder
pka	2.06±0.10(Predicted)
color	Brown-red
Water Solubility	1.2 g/L (20 ºC)
Merck	14,6622
BRN	608106
Henry's Law Constant	1.3×10⁶ mol/(m³Pa) at 25℃, HSDB (2015)
Stability	Stable. Incompatible with strong acids, strong reducing agents, strong oxidizing agents, acid chlorides, acid anhydrides.
Cosmetics Ingredients Functions	HAIR DYEING
Cosmetic Ingredient Review (CIR)	4-Nitro-o-phenylenediamine (99-56-9)
InChI	1S/C6H7N3O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,7-8H2
InChIKey	RAUWPNXIALNKQM-UHFFFAOYSA-N
SMILES	Nc1ccc(cc1N)[N+]([O-])=O
Toxicology and Carcinogenesis	Bioassay of 4-Nitro-o-phenylenediamine for Possible Carcinogenicity (CASRN 99-56-9)
CAS DataBase Reference	99-56-9(CAS DataBase Reference)
EWG's Food Scores	3-5
FDA UNII	5A9AX7Y0TT
IARC	3 (Vol. 16, Sup 7) 1987
EPA Substance Registry System	Nitro-o-phenylenediamine (99-56-9)
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H317

Precautionary statements

P280-P301+P312+P330-P302+P352

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xn

Risk Statements

22-43-68-40-36/37/38-20/21/22

Safety Statements

36/37-45-36-26-22

RIDADR

2811

WGK Germany

3

RTECS

ST2975000

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

II

HS Code

29215119

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Skin Sens. 1

Hazardous Substances Data

99-56-9(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 681mg/kg

NFPA 704

	1
2		0

4-Nitro-o-phenylenediamine price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	108898	4-Nitro-o-phenylenediamine 98%	99-56-9	5g	$40	2026-04-30	Buy
Sigma-Aldrich	77833	4-Nitro-o-phenylenediamine analytical standard	99-56-9	100 mg	$68.9	2026-04-30	Buy
Sigma-Aldrich	108898	4-Nitro-o-phenylenediamine 98%	99-56-9	100g	$111	2026-04-30	Buy
TCI Chemical	D0103	4-Nitro-1,2-phenylenediamine >97.0%(GC)(T)	99-56-9	25g	$22	2026-04-30	Buy
TCI Chemical	D0103	4-Nitro-1,2-phenylenediamine >97.0%(GC)(T)	99-56-9	100g	$52	2026-04-30	Buy

Product number	Packaging	Price	Buy
108898	5g	$40	Buy
77833	100 mg	$68.9	Buy
108898	100g	$111	Buy
D0103	25g	$22	Buy
D0103	100g	$52	Buy

4-Nitro-o-phenylenediamine Chemical Properties, Uses, Production

Chemical Properties

This substance is an orange-red powder that can be dissolved in ethanol, acetone, and hydrochloric acid solution, but is not soluble in water.

Uses

4-Nitro-o-phenylenediamine was used to study the in vitro activation of 4-nitro-o-phenylenediamine into a potent mutagen in Salmonella typhimurium strain TA98 .

Application

4-Nitro-1,2-phenylenediamine is a hair dye constituent with potential mutagenic activity. It is used in oxidation hair dye formulations at a maximum concentration of 1.0 %, which after mixing typically in a 1:1 ratio with hydrogen peroxide just prior to use, corresponds to a concentration of 0.5% upon application.

Preparation

Prepared by reduction of 2,4-dinitroaniline using H2S in ammonia water.

Definition

ChEBI: 4-nitro-1,2-phenylenediamine is the primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group. It is a primary amino compound and a C-nitro compound. It is functionally related to a 1,2-phenylenediamine.

Production Methods

Commercial production of 4-nitro-o-PDA was first reported in the United States in 1946. Two U.S. companies were reported to produce undisclosed amounts of the chemical in 1975. U.S. imports of 4-nitro-o-PDA were reported to be about 1900 kg in 1973 and 1100 kg in 1975. 4-Nitro-o-PDAis used in fur dyes, inks, and semipermanent yellow hair coloring formulations requiring a yellow color component that does not involve the use of hydrogen peroxide in the color development.
Occupational exposure to 4-nitro-o-PDA may occur through inhalation and dermal contact with this compound at workplaces where p-PDA is produced or used. The general population may be exposed to the compound via dermal contact, primarily through the use of hair dyes containing this compound.

General Description

4-nitro-o-phenylenediamine appears as dark red needles or red solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Nitro-o-phenylenediamine is incompatible with strong oxidizing agents, strong acids, strong reducing agents, acid chlorides and acid anhydrides.

Fire Hazard

Flash point data for 4-Nitro-o-phenylenediamine are not available; however, 4-Nitro-o-phenylenediamine is probably combustible.

Biochem/physiol Actions

4-Nitro-o-phenylenediamine is a direct-acting mutagen.

Safety Profile

Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx,.

Purification Methods

Crystallise the diamine from water. [Beilstein 13 IV 75.]

References

[1] New Journal of Chemistry, 2015, vol. 39, # 11, p. 8498 - 8504
[2] Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4992 - 4993
[3] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 001201
[4] Chemische Berichte, 1899, vol. 32, p. 900
[5] Chemische Berichte, 1888, vol. 21, p. 2306

4-Nitro-o-phenylenediamine synthesis

Synthesis of 4-Nitro-o-phenylenediamine from 2,4-Dinitroaniline

4-Nitro-o-phenylenediamine Preparation Products And Raw materials

Raw materials

2,4-Dinitroaniline Activated carbon,decolor Benzenamine, N-hydroxy-2,4-dinitro- benzene-1,2,4-triyltriamine Ethanol

2,5-Dinitroaniline 2-Chloro-5-nitro-benzamine 2,4-Dinitroacetanilide 1-Methoxy-2,4-dinitrobenzene 4'-Nitroacetanilide

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Preparation Products

6-Aminoquinoxaline 5-Bromo-6-isothiocyanate quinoxaline 5-Amino-2-benzimidazolethiol 5-Bromoquinoxalin-6-amine 2-Mercapto-5-nitrobenzimidazole

6-Nitro-1H-benzoimidazole-2-thiol Platinum,dichlorobis(dimethylphenylphosphine)-, (SP-4-2)- 1,4-Diamino-2-nitrobenzene 1H-Benzimidazole,1-methyl-5-nitro-(9CI) 5-Nitrobenzimidazole

4-(5-nitro-H-benzimidazol-2-yl)aniline

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4-Nitro-o-phenylenediamine Suppliers

Global Suppliers ( 467)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Taijilin Industrial Co., Ltd.	02150630626 17717886015	kate@tajilin.com	China	1340	58
Shanghai Qiao Chemical Science Co., Ltd	021-58892003	info@qiaochem.com	China	6065	65
Changsha Changtang Import and Export Co., LTD	18942506900 18942506900	492657010@qq.com	China	995	58
Hefei Ruiluo New Material Technology Co., Ltd.	19567218739	1759672789@qq.com	China	569	58
Hangzhou Bingochem Co., Ltd.	0571-87658025	sales@bingochem.com	China	21532	58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.	0513-82104991 18862997351	sales11@btcpharm.com	China	859	58
LEWOO PHARMATECH (SHANGHAI) CO.,LTD	15800805830	miao@lewoopharma.com.cn	China	994	58
Hangzhou Beishengyuan Biotechnology Co., Ltd	15700194842 15700194842	1289372011@qq.com	China	156	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62

Supplier	Advantage
Shanghai Taijilin Industrial Co., Ltd.	58
Shanghai Qiao Chemical Science Co., Ltd	65
Changsha Changtang Import and Export Co., LTD	58
Hefei Ruiluo New Material Technology Co., Ltd.	58
Hangzhou Bingochem Co., Ltd.	58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.	58
LEWOO PHARMATECH (SHANGHAI) CO.,LTD	58
Hangzhou Beishengyuan Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62

View Latest Price from 4-Nitro-o-phenylenediamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	4-Nitro-o-phenylenediamine 99-56-9			0.99		RongNa Biotechnology Co.,Ltd
2026-09-02	4-Nitro-o-phenylenediamine 99-56-9	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-08-03	4-Nitro-o-phenylenediamine 99-56-9		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

4-Nitro-o-phenylenediamine
99-56-9
0.99
RongNa Biotechnology Co.,Ltd

4-Nitro-o-phenylenediamine
99-56-9
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

4-Nitro-o-phenylenediamine
99-56-9
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

4-Nitro-o-phenylenediamine Spectrum

4-Nitro-o-phenylenediamine(99-56-9)MS 4-Nitro-o-phenylenediamine(99-56-9)¹HNMR 4-Nitro-o-phenylenediamine(99-56-9)¹³CNMR 4-Nitro-o-phenylenediamine(99-56-9)IR1 4-Nitro-o-phenylenediamine(99-56-9)IR2 4-Nitro-o-phenylenediamine(99-56-9)Raman

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4-nop 4-nopd 4-n-o-pda nci-c03941 p-nitro-o-phenylenediamine o-Phenylenediamine, 4-nitro- WLN: ZR BZ DNW 202-766-3 4-Nitro-1,2-phenylenediamine for synthesis 4-Nitrophenylene-1,2-diamine 4-Nitro-O-Phenylenediamine(HcBrown4N) 4-Nitro-o-phenylenediamine, 98+% PARA-NITRO-ORTHO-PHENYLENEDIAMINE 4-NITRO-ORTHO-PHENYLENE-DIAMINE 4-NITRO-ORTHO-DIAMINOPHENYLENE NITRO-ORTHO-PHENYLENEDIAMINE o-Phenylenediamine, 4-nitro-2-amino-4-nitroaniline 4-Nitrophenylenediamine,97% C.I.Oxidation Base 9 4-Nitro-O-Phenylene Diamine (Hair Brown 4N) 4-Nitro-1,2-phenylenedlamine 2-DiaMino-4-nitrobenzene 4-Nitro-o-phenylenediaMine, 98% 100GR 4-Nitro-o-phenylenediaMine, 98% 500GR 2-AMino-4-nitrophenyl)aMine 2-AMino-5-nitroaniline 4-Nitro-2-aM 4-NITRO-1,2-PHENYLENEDIAMINE FOR SYNTHES 4-Nitro-o-phenylenediaMine, 97+% (2-amino-5-nitro-phenyl)amine 4-Nitro-1,2-fenylendiamin [Czech] 4-Nitro-para-phenylenediamine 4-Nitro-o-phenyL 4-NITRO-2-PHENYLENEDIAMINE 4-NITRO-O-PHENYLDIAMINE 4-NITRO-O-PHENYLENEDIAMINE 3,4-Diaminonitrobenzene 2-amino-4-nitroaniline 1,2-DIAMINO-4-NITROBENZENE TIMTEC-BB SBB007571 1,2-Benzenediamine,4-nitro- 1,2-benzenediamine,-nitro- 2-Benzenediamine,4-nitro-1 4ndb 4-nitro-1,2-benzenediamine 4-nitro-1,2-diaminobenzene 4-nitro-1,2-fenylendiamin 4-nitro-2-benzenediamine 4-nitro-o-phenylenediamin 4-nitrophenylenediamine c.i. 76020 JAROCOL 4NOPD 4-Nitro-1,2-phenylenediamine > 4-Nitro-o-phenylenediamine ISO 9001：2015 REACH 4-Nitro-O-phenelene diamine 4-Nitro-1,2-phenylendiamin TIANFU-CHEM 4-Nitro-o-phenylenediamine, 98% 4 NITRO ORTHO PHENYLENE DIAMINE (4 NITRO OPD )