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Fmoc-Tyr(Me)-OH

Fmoc-Tyr(Me)-OH Structure
Fmoc-Tyr(Me)-OH structure
CAS No.
77128-72-4
Chemical Name:
Fmoc-Tyr(Me)-OH
Synonyms
Fmoc;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-Methoxyphenyl)propanoic acid;Fmoc-Tyr(me);FMOC-PHE(4-OME)-OH;FMOC-L-TYR(ME);FMOC-TYR(ME)-OH;FMOC-TYR(AL)-OH;FMOC-L-TYR(ME)-OH;Fmoc-4-Methoxy-Phe;FMOC-L-4-METHOXYPHE
CBNumber:
CB1468274
Molecular Formula:
C25H23NO5
Molecular Weight:
417.45
MDL Number:
MFCD00153368
MOL File:
77128-72-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:41:51
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Fmoc-Tyr(Me)-OH Properties

Melting point 161 °C
Boiling point 647.8±55.0 °C(Predicted)
Density 1.274±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
pka 2.97±0.10(Predicted)
form powder to crystal
color White to Almost white
optical activity -26.3° (C=0.01 g/ml, DMF)
Major Application peptide synthesis
InChIKey JYQODLWFOPCSCS-QHCPKHFHSA-N
SMILES C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference 77128-72-4(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
WGK Germany  WGK 2 water endangering
HazardClass  IRRITANT
HS Code  29242990
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

Fmoc-Tyr(Me)-OH price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52056 Fmoc-Tyr(Me)-OH Novabiochem? 77128-72-4 5G $132 2026-04-30 Buy
Sigma-Aldrich CDS006940 Fmoc-Tyr(Me)-OH AldrichCPR 77128-72-4 10MG $68.1 2023-06-20 Buy
Sigma-Aldrich 8.52056 Fmoc-Tyr(Me)-OH Novabiochem? 77128-72-4 1g $35.3 2023-01-07 Buy
TCI Chemical F1038 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine 77128-72-4 1G $58 2026-04-30 Buy
TCI Chemical F1038 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine 77128-72-4 5G $192 2026-04-30 Buy
Product number Packaging Price Buy
8.52056 5G $132 Buy
CDS006940 10MG $68.1 Buy
8.52056 1g $35.3 Buy
F1038 1G $58 Buy
F1038 5G $192 Buy

Fmoc-Tyr(Me)-OH Chemical Properties, Uses, Production

Uses

Fmoc-p-methoxy-L-phenylalanine is a phenylalanine derivative protected by the Fmoc (9-fluorenylmethoxycarbonyl) group. The Fmoc protecting group is easily removed under mild conditions without destroying the amino acid's activity, making this compound an indispensable raw material in peptide synthesis. It can also be used as a key intermediate in the synthesis of ACE inhibitors for treating hypertension.

Description

Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.

Chemical Properties

White to off-white powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid  Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.

References

[1] Berthet M, et al. MgI2 -Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies. Chemistry - A European Journal, 2015; 21: 11014-11016.

Fmoc-Tyr(Me)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

Fmoc-Tyr(Me)-OH Suppliers

Global Suppliers ( 218)
Supplier Tel Email Country ProdList Advantage
Sichuan HongRi Pharma-Tech Co., Ltd 1898-2685405 18380436509 2065506070@qq.com China 1930 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Shanghai HC Biotech Co., Ltd 021-20227858 sale@hcbiotech.com.cn China 1173 55
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787 service@chempep.com United States 2138 57
Supplier Advantage
Sichuan HongRi Pharma-Tech Co., Ltd 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Shanghai HC Biotech Co., Ltd 55
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
ChemPep, Inc. 57

View Latest Price from Fmoc-Tyr(Me)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-L-Tyr(me) pictures 2026-09-17 Fmoc-L-Tyr(me)
77128-72-4
 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
Fmoc-Tyr(Me)-OH pictures 2026-08-13 Fmoc-Tyr(Me)-OH
77128-72-4
 1KG 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
FMOC-TYR(ME)-OH pictures 2019-07-06 FMOC-TYR(ME)-OH
77128-72-4
 $1.00 1KG 99% 20kg Career Henan Chemical Co

Fmoc-Tyr(Me)-OH Spectrum

Fmoc-Tyr(Me)-OH(77128-72-4)1HNMR

77128-72-4 (Fmoc-Tyr(Me)-OH) Related Search:

FMOC-TYR(BZL)-OH 98%,FMOC-TYR(BZL)-OH (S)-N-Fmoc-Allylglycine Fmoc-4-nitro-L-phenylalanine FMOC-L-4-Methylphe (S)-N-FMOC-4-Chlorophenylalanine
Fmoc-L-4-Iodophenylalanine FMOC-L-4-Fluorophe Fmoc-Tyr(Ac)-OH N-Fmoc-O-Phenyl-L-Tyrosine Fmoc-d, L-Phe(4-c(o)NH2)
Fmoc-L-4-cyanophenylalanine Fmoc-L-9-anthrylalanine Fmoc-L-Tyr(all)-OH Fmoc-O-ethyl-L-tyrosine 4-Methoxy-L-phenylalanine
Fmoc-Tyr(Me)-OH Fmoc-Tyr(tBu)-OH Fmoc-D-Tyr(tBu)-OH

1of4

Fmoc-4-Methoxy-L-Phe-OH Methoxy phenylalanine N-FMoc-4-Methoxy-L-phenylalanine, 95% FMoc-Tyr(Me)-OH FMoc-O-Methyl-L-tyrosine FMOC-(S)-b-(p-Methoxyphenyl)alanine N-Fmoc-O-methyl-L-tyrosine, >=99% Fmoc-4-Methoxy-Phe N-ALPHA-FMOC-O-METHYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-METHYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHYL-L-TYROSINE N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine Fmoc-O-methyl-L-tyrosine≥ 99% (HPLC) Fmoc-Tyr(Me)-OH Novabiochem N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHY-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-METHOXY-L-PHENYLALANINE (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-(4-METHOXY-PHENYL)-PROPIONIC ACID FMOC-4-METHOXY-PHE-OH FMOC-4-METHOXY-L-PHENYLALANINE FMOC-4-METHOXYPHENYLALANINE FMOC-L-4-METHOXYPHE FMOC-TYR(ME)-OH FMOC-L-TYR(ME) FMOC-L-TYR(ME)-OH FMOC-L-TYROSINE(METHYL ETHER) FMOC-P-METHOXY-PHE-OH FMOC-O-METHYL-L-TYROSINE FMOC-4-METHOXYPHENYLALANINE MIN 99% Fmoc-L-4-MeO-Phe-OH FMOC-TYR(AL)-OH (9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(Me)-OH (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxyphenyl)propanoic acid Fmoc-Tyr(Me)-OH(Fmoc-4-Methoxy-Phe) N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine> Fmoc-Tyr(Me)-OH (N-Fmoc-O-methyl-L-tyrosine) L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl- N-Fmoc-4-methoxy-L-phenylalanine,95% N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxy-L-phenylalanine N-Fmoc-O-methyl-L-tyrosine FMOC-TYR(ME)-OH USP/EP/BP N-Fmoc-4-methoxy-L-phenylalanine FMOC-PHE(4-OME)-OH Fmoc-L-Tyr( OMe)-OH (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-Methoxyphenyl)propanoic acid Fmoc Fmoc-Tyr(me) Fmoc?L?4?methoxyphenylglycine 77128-72-4 Phenylalanine [Phe, F] Unusual Amino Acids Amino Acids Fmoc-Amino acid series