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Fmoc-Tyr(Me)-OH

Fmoc-Tyr(Me)-OH Structure
Fmoc-Tyr(Me)-OH structure
CAS No.
77128-72-4
Chemical Name:
Fmoc-Tyr(Me)-OH
Synonyms
Fmoc;FMOC-PHE(4-OME)-OH;Fmoc-Tyr(me);FMOC-L-TYR(ME);FMOC-TYR(ME)-OH;FMOC-TYR(AL)-OH;FMOC-L-TYR(ME)-OH;Fmoc-4-Methoxy-Phe;FMOC-L-4-METHOXYPHE;Fmoc-L-4-MeO-Phe-OH
CBNumber:
CB1468274
Molecular Formula:
C25H23NO5
Molecular Weight:
417.45
MDL Number:
MFCD00153368
MOL File:
77128-72-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:17
Product description Number Pack Size Price
Fmoc-Tyr(Me)-OH Novabiochem? 8.52056 5G $132
Fmoc-Tyr(Me)-OH AldrichCPR CDS006940 10MG $68.1
Fmoc-Tyr(Me)-OH Novabiochem? 8.52056 1g $35.3
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine F1038 1G $58
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine F1038 5G $192
More product size
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Fmoc-Tyr(Me)-OH Properties

Melting point 161 °C
Boiling point 647.8±55.0 °C(Predicted)
Density 1.274±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
pka 2.97±0.10(Predicted)
form powder to crystal
color White to Almost white
optical activity -26.3° (C=0.01 g/ml, DMF)
Major Application peptide synthesis
InChIKey JYQODLWFOPCSCS-QHCPKHFHSA-N
SMILES C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference 77128-72-4(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
WGK Germany  WGK 2 water endangering
HazardClass  IRRITANT
HS Code  29242990
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

Fmoc-Tyr(Me)-OH price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52056 Fmoc-Tyr(Me)-OH Novabiochem? 77128-72-4 5G $132 2026-03-19 Buy
Sigma-Aldrich CDS006940 Fmoc-Tyr(Me)-OH AldrichCPR 77128-72-4 10MG $68.1 2023-06-20 Buy
Sigma-Aldrich 8.52056 Fmoc-Tyr(Me)-OH Novabiochem? 77128-72-4 1g $35.3 2023-01-07 Buy
TCI Chemical F1038 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine 77128-72-4 1G $58 2026-03-19 Buy
TCI Chemical F1038 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine 77128-72-4 5G $192 2026-03-19 Buy
Product number Packaging Price Buy
8.52056 5G $132 Buy
CDS006940 10MG $68.1 Buy
8.52056 1g $35.3 Buy
F1038 1G $58 Buy
F1038 5G $192 Buy

Fmoc-Tyr(Me)-OH Chemical Properties,Uses,Production

Uses

Fmoc-p-methoxy-L-phenylalanine is a phenylalanine derivative protected by the Fmoc (9-fluorenylmethoxycarbonyl) group. The Fmoc protecting group is easily removed under mild conditions without destroying the amino acid's activity, making this compound an indispensable raw material in peptide synthesis. It can also be used as a key intermediate in the synthesis of ACE inhibitors for treating hypertension.

Description

Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.

Chemical Properties

White to off-white powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid  Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.

References

[1] Berthet M, et al. MgI2 -Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies. Chemistry - A European Journal, 2015; 21: 11014-11016.

Fmoc-Tyr(Me)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

Fmoc-Tyr(Me)-OH Suppliers

Global( 207)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd
+8618382028708 ni@enlaibio.com China 1098 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29821 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Nanjing Fred Technology Co., Ltd. 		+86-02584696168 15380713688 Austin@fredchem.cn CHINA 865 58
Supplier Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd
58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
Nanjing Fred Technology Co., Ltd. 		58

View Lastest Price from Fmoc-Tyr(Me)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-L-Tyr(me) pictures 2026-04-24 Fmoc-L-Tyr(me)
77128-72-4
 US $0.00-0.00 / kg 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
Fmoc-Tyr(Me)-OH pictures 2026-03-30 Fmoc-Tyr(Me)-OH
77128-72-4
 US $0.00-0.00 / KG 1KG 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
FMOC-TYR(ME)-OH pictures 2019-07-06 FMOC-TYR(ME)-OH
77128-72-4
 US $1.00 / KG 1KG 99% 20kg Career Henan Chemical Co
  • Fmoc-L-Tyr(me) pictures
  • Fmoc-L-Tyr(me)
    77128-72-4
  • US $0.00-0.00 / kg
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd
  • Fmoc-Tyr(Me)-OH pictures
  • Fmoc-Tyr(Me)-OH
    77128-72-4
  • US $0.00-0.00 / KG
  • 98%
  • Shenzhen Nexcon Pharmatechs Ltd.

Fmoc-Tyr(Me)-OH Spectrum

Fmoc-Tyr(Me)-OH(77128-72-4)1HNMR

77128-72-4(Fmoc-Tyr(Me)-OH)Related Search:

FMOC-TYR(BZL)-OH 98%,FMOC-TYR(BZL)-OH N-Fmoc-O-Phenyl-L-Tyrosine Fmoc-Tyr(Ac)-OH FMOC-L-4-Fluorophe Fmoc-L-4-Iodophenylalanine
(S)-N-FMOC-4-Chlorophenylalanine FMOC-L-9-ANTHRYLALANINE FMOC-D, L-PHE(4-C(O)NH2) FMOC-L-4-Methylphe Fmoc-4-nitro-L-phenylalanine
(S)-N-Fmoc-Allylglycine FMOC-L-4-CYANOPHENYLALANINE FMOC-TYR(ET)-OH FMOC-TYR(ALL)-OH,FMOC-TYR(AL)-OH FMOC-TYR(2-BR-Z)-OH
FMOC-TYR(MALONYL-DI-OTBU)-OH Fmoc-Tyr(tBu)-OH Fmoc-Tyr(Me)-OH

1of4

Fmoc-4-Methoxy-L-Phe-OH Methoxy phenylalanine N-FMoc-4-Methoxy-L-phenylalanine, 95% FMoc-Tyr(Me)-OH FMoc-O-Methyl-L-tyrosine FMOC-(S)-b-(p-Methoxyphenyl)alanine (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-Methoxyphenyl)propanoic acid N-Fmoc-O-methyl-L-tyrosine, >=99% Fmoc-4-Methoxy-Phe N-ALPHA-FMOC-O-METHYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-METHYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHYL-L-TYROSINE N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine Fmoc-O-methyl-L-tyrosine≥ 99% (HPLC) Fmoc-Tyr(Me)-OH Novabiochem N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHY-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-METHOXY-L-PHENYLALANINE (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-(4-METHOXY-PHENYL)-PROPIONIC ACID FMOC-4-METHOXY-PHE-OH FMOC-4-METHOXY-L-PHENYLALANINE FMOC-4-METHOXYPHENYLALANINE FMOC-L-4-METHOXYPHE FMOC-TYR(ME)-OH FMOC-L-TYR(ME) FMOC-L-TYR(ME)-OH FMOC-L-TYROSINE(METHYL ETHER) FMOC-P-METHOXY-PHE-OH FMOC-O-METHYL-L-TYROSINE FMOC-4-METHOXYPHENYLALANINE MIN 99% Fmoc-L-4-MeO-Phe-OH FMOC-TYR(AL)-OH (9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(Me)-OH (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxyphenyl)propanoic acid Fmoc-Tyr(Me)-OH(Fmoc-4-Methoxy-Phe) N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine> Fmoc-Tyr(Me)-OH (N-Fmoc-O-methyl-L-tyrosine) L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl- N-Fmoc-4-methoxy-L-phenylalanine,95% N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxy-L-phenylalanine N-Fmoc-O-methyl-L-tyrosine FMOC-TYR(ME)-OH USP/EP/BP N-Fmoc-4-methoxy-L-phenylalanine Fmoc-Tyr(me) FMOC-PHE(4-OME)-OH Fmoc 77128-72-4 Phenylalanine [Phe, F] Unusual Amino Acids Amino Acids Fmoc-Amino acid series