Fmoc-Tyr(Me)-OH
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Fmoc-Tyr(Me)-OH 속성
- 녹는점
- 161 °C
- 끓는 점
- 647.8±55.0 °C(Predicted)
- 밀도
- 1.274±0.06 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,2-8°C
- 산도 계수 (pKa)
- 2.97±0.10(Predicted)
- 물리적 상태
- powder to crystal
- 색상
- 흰색에서 거의 흰색
- ??? (Optical Rotation)
- -26.3° (C=0.01 g/ml, DMF)
- InChIKey
- JYQODLWFOPCSCS-QHCPKHFHSA-N
- SMILES
- C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- CAS 데이터베이스
- 77128-72-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | WGK 2 water endangering | ||
|---|---|---|---|
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29242990 |
Fmoc-Tyr(Me)-OH C화학적 특성, 용도, 생산
개요
Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.화학적 성질
White to off-white powderSynthesis
Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.
Fmoc-Tyr(Me)-OH 준비 용품 및 원자재
원자재
준비 용품
Fmoc-Tyr(Me)-OH 공급 업체
글로벌( 215)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8617390183901 |
cynthia@enlaibio.com | China | 1100 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 |
sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29852 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 |
sales@amoychem.com | China | 6369 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49975 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 |
sale@simagchem.com | China | 17346 | 58 |
Fmoc-Tyr(Me)-OH 관련 검색:
Fmoc-4-니트로-L-페닐알라닌 Fmoc-L-4-카르바모일프 FMOC-L-9-안트릴알라닌 FMOC-O-에틸-L-티로신 FMOC-L-TYR(모두)-OH FMOC-O-BUTYL-L-TYROSINEN-HYDROXYSUCCINIMIDE에스테르 FMOC-L-티로닌 FMOC-L-티록신 (S)-FMOC-2-메톡시페닐알라닌 FMOC-D-TYR(모두)-OH FMOC-TYR(2,6-디클로로-BZL)-OH FMOC-베타-(2,2-디메틸-4H-벤조[1,3]-디옥신-6-일)-ALA-OH
FMOC-TYR(BZL)-OH 98%,FMOC-TYR(BZL)-OH
N-Fmoc-O-Phenyl-L-Tyrosine
Fmoc-Tyr(Ac)-OH
FMOC-L-4-Fluorophe
Fmoc-L-4-Iodophenylalanine
(S)-N-FMOC-4-Chlorophenylalanine