E3 ligase Ligand-Linker Conjugates 8
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- $305 - $5480
- Product name: E3 ligase Ligand-Linker Conjugates 8
- CAS: 1835705-55-9
- MF: C38H59ClN4O7S
- MW: 751.42
- EINECS:
- MDL Number:MFCD31560478
- Synonyms:E3 ligase Ligand-Linker Conjugates 8;(S,R,S)-AHPC-C6-PEG3-butyl chloride;VHL Ligand-Linker Conjugates 12;VH032-C6-PEG3-C4-Cl;(S,R,S)-AHPC-6-2-2-6-Cl;L-Prolinamide, N-[6-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;2S,4R)-1-((S)-2-(tert-Butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-6-2-2-6-Cl, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate;(S,R,S)-AHPC-C?-PEG?-butyl chloride
18 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Biosynth
- BroadPharm
- ChemScene
- Iris Biotech GmbH
- Sigma-Aldrich
Package
- 25MG
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 2g
- Manufactureraablocks
- Product numberAA01EO71
- Product description(S，R，S)-AHPC-C6-PEG3-C4-Cl >98%
- Packaging50mg
- Price$418
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO71
- Product description(S，R，S)-AHPC-C6-PEG3-C4-Cl >98%
- Packaging100mg
- Price$647
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO71
- Product description(S，R，S)-AHPC-C6-PEG3-C4-Cl >98%
- Packaging500mg
- Price$2202
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO71
- Product description(S，R，S)-AHPC-C6-PEG3-C4-Cl >98%
- Packaging1g
- Price$3758
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EO71
- Product description(S，R，S)-AHPC-C6-PEG3-C4-Cl >98%
- Packaging2g
- Price$5480
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD255222
- Product description(2S,4R)-1-((S)-2-(tert-butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 95%
- Packaging25MG
- Price$305
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD255222
- Product description(2S,4R)-1-((S)-2-(tert-butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 95%
- Packaging100MG
- Price$795
- Updated2026-05-27
- Buy
- ManufacturerBiosynth
- Product numberKYC70555
- Product description(S,R,S)-AHPC-C6-PEG3-butyl chloride
- Packaging250mg
- Price$1480
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberKYC70555
- Product description(S,R,S)-AHPC-C6-PEG3-butyl chloride
- Packaging100mg
- Price$788
- Updated2026-06-04
- Buy
- ManufacturerBroadPharm
- Product numberbp-44843
- Product description(S,R,S)-AHPC-C6-PEG3-C4-Cl
- Packaging50MG
- Price$344
- Updated2026-05-24
- Buy
- ManufacturerBroadPharm
- Product numberbp-44843
- Product description(S,R,S)-AHPC-C6-PEG3-C4-Cl
- Packaging100MG
- Price$550
- Updated2026-05-24
- Buy
- ManufacturerChemScene
- Product numberCS-7748
- Product description(S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01%
- Packaging100mg
- Price$596
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-7748
- Product description(S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01%
- Packaging50mg
- Price$373
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-7748
- Product description(S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01%
- Packaging500mg
- Price$2112
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-7748
- Product description(S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01%
- Packaging2g
- Price$5308
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-7748
- Product description(S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01%
- Packaging1g
- Price$3629
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01EO71 | (S，R，S)-AHPC-C6-PEG3-C4-Cl >98% | 50mg | $418 | 2026-05-30 | Buy |
| aablocks | AA01EO71 | (S，R，S)-AHPC-C6-PEG3-C4-Cl >98% | 100mg | $647 | 2026-05-30 | Buy |
| aablocks | AA01EO71 | (S，R，S)-AHPC-C6-PEG3-C4-Cl >98% | 500mg | $2202 | 2026-05-30 | Buy |
| aablocks | AA01EO71 | (S，R，S)-AHPC-C6-PEG3-C4-Cl >98% | 1g | $3758 | 2026-05-30 | Buy |
| aablocks | AA01EO71 | (S，R，S)-AHPC-C6-PEG3-C4-Cl >98% | 2g | $5480 | 2026-05-30 | Buy |
| ACHEMBLOCK | AD255222 | (2S,4R)-1-((S)-2-(tert-butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 95% | 25MG | $305 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD255222 | (2S,4R)-1-((S)-2-(tert-butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 95% | 100MG | $795 | 2026-05-27 | Buy |
| Biosynth | KYC70555 | (S,R,S)-AHPC-C6-PEG3-butyl chloride | 250mg | $1480 | 2026-06-04 | Buy |
| Biosynth | KYC70555 | (S,R,S)-AHPC-C6-PEG3-butyl chloride | 100mg | $788 | 2026-06-04 | Buy |
| BroadPharm | bp-44843 | (S,R,S)-AHPC-C6-PEG3-C4-Cl | 50MG | $344 | 2026-05-24 | Buy |
| BroadPharm | bp-44843 | (S,R,S)-AHPC-C6-PEG3-C4-Cl | 100MG | $550 | 2026-05-24 | Buy |
| ChemScene | CS-7748 | (S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01% | 100mg | $596 | 2026-06-04 | Buy |
| ChemScene | CS-7748 | (S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01% | 50mg | $373 | 2026-06-04 | Buy |
| ChemScene | CS-7748 | (S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01% | 500mg | $2112 | 2026-06-04 | Buy |
| ChemScene | CS-7748 | (S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01% | 2g | $5308 | 2026-06-04 | Buy |
| ChemScene | CS-7748 | (S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01% | 1g | $3629 | 2026-06-04 | Buy |
Properties
Boiling point :924.3±65.0 °C(Predicted)
Density :1.174±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Ethanol: 100 mg/mL (133.08 mM); DMSO: ≥ 100 mg/mL (133.08 mM)
form :Oil
pka :14.08±0.40(Predicted)
color :Light yellow to yellow
InChIKey :MLRLOIWXHCPWFF-MEEYNGGZSA-N
SMILES :ClCCCCCCOCCOCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O
Density :1.174±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Ethanol: 100 mg/mL (133.08 mM); DMSO: ≥ 100 mg/mL (133.08 mM)
form :Oil
pka :14.08±0.40(Predicted)
color :Light yellow to yellow
InChIKey :MLRLOIWXHCPWFF-MEEYNGGZSA-N
SMILES :ClCCCCCCOCCOCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O
Safety Information
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Description
Protein degrader builiding block (S,R,S)-AHPC-C6-PEG3-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.More related product prices
E3 ligase Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 8Related product price
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E3 ligase Ligand-Linker Conjugates 7
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E3 ligase Ligand-Linker Conjugates 8
$305-5480
Suppliers and manufacturers
Sichuan Wei Keqi Biological Technology Co., Ltd.
Sigma-Aldrich
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