Methyl 4-hydroxycyclohexanecarboxylate
- CAS No.
- 17449-76-2
- Chemical Name:
- Methyl 4-hydroxycyclohexanecarboxylate
- Synonyms
- METHYL 4-HYDROXYCYCLOHEXANE-1-CARBOXYLATE;Methyl 4-hydroxycyclohexanecarboxylate;HYDROXYCYCLOHEXANECARBOXYLIC ACID METHYL ESTER;4-Hydroxycyclohexanecarboxylic acid methyl ester;Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester;METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE ISO 9001：2015 REACH;4-(Methoxycarbonyl)cyclohexan-1-ol, 1-Hydroxy-4-(methoxycarbonyl)cyclohexane
- CBNumber:
- CB1490323
- Molecular Formula:
- C8H14O3
- Molecular Weight:
- 158.2
- MDL Number:
- MFCD00729087
- MOL File:
- 17449-76-2.mol
- MSDS File:
- SDS
| Boiling point | 233℃ |
|---|---|
| Density | 1.121 |
| Flash point | 94℃ |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 14.96±0.40(Predicted) |
| form | liquid |
| color | Brown |
| InChI | InChI=1S/C8H14O3/c1-11-8(10)6-2-4-7(9)5-3-6/h6-7,9H,2-5H2,1H3 |
| InChIKey | HYDYVXROZHFTGB-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)CCC(O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H335-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2902110000 |
Methyl 4-hydroxycyclohexanecarboxylate price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR27594 | Methyl 4-hydroxycyclohexane-1-carboxylate 95% | 17449-76-2 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR27594 | Methyl 4-hydroxycyclohexane-1-carboxylate 95% | 17449-76-2 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR27594 | Methyl 4-hydroxycyclohexane-1-carboxylate 95% | 17449-76-2 | 500mg | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR27594 | Methyl 4-hydroxycyclohexane-1-carboxylate 95% | 17449-76-2 | 1g | $32 | 2026-06-04 | Buy |
| Apolloscientific | OR27594 | Methyl 4-hydroxycyclohexane-1-carboxylate 95% | 17449-76-2 | 5g | $41 | 2026-06-04 | Buy |
Methyl 4-hydroxycyclohexanecarboxylate Chemical Properties, Uses, Production
Synthesis
99-76-3
3618-03-9
Example 1: To a Parr high pressure reaction flask was added 150 mL of methanol followed by 25 g of methyl 4-hydroxybenzoate (nipagin methyl ester). After displacing the air in the reaction flask with nitrogen, 2.5 g of 5% rhodium/alumina catalyst was added. The reaction mixture was pressurized to 3.74 MPa under hydrogen atmosphere and the reaction was continuously shaken at room temperature for 18 hours. Upon completion of the reaction, the hydrogen was replaced with nitrogen and the reaction mixture was filtered through a diatomaceous earth pad to separate the catalyst. The diatomaceous earth pad was washed with methanol, taking care to avoid drying of the catalyst. The filtrate and washings were combined and concentrated under reduced pressure at 40 °C to remove methanol. The residue was dissolved in 200 mL of ether and 3 g of anhydrous potassium carbonate was added. The precipitated alumina and potassium carbonate were removed by diatomaceous earth filtration and washed with ether. The filtrates were combined and the solvent was removed under reduced pressure to give the crude product. The crude product was distilled by a Kugelrohr short-range distillation apparatus at 80-100 °C/1 mmHg to give 25.0 g (98% yield) of methyl 4-hydroxycyclohexanecarboxylate (cis-4-hydroxycyclohexanecarboxylic acid methyl ester). The product was characterized by 1H NMR (CDCl3, 60 MHz): δ 3.85 (s, 1H); 3.65 (s, 3H); 2.50-1.20 (m, 10H).
References
[1] Canadian Journal of Chemistry, 1982, vol. 60, p. 1996 - 2001
[2] Journal of Organic Chemistry, 1991, vol. 56, # 5, p. 1758 - 1763
[3] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 23, p. 6309 - 6323
[4] Bulletin de la Societe Chimique de France, 1970, p. 556 - 562
[5] Bulletin de la Societe Chimique de France, 1969, p. 781 - 787
Methyl 4-hydroxycyclohexanecarboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Elitechemie MediPharma Technology Co., Ltd. | 523-86810021 18921709486 | gwli@elitechemie.com | China | 500 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824; | bjkaida@163.com | China | 1596 | 59 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Shanghai Huikai Chemical Technology Co., Ltd. | 021-61995394 18916691159 | chemicalsea@163.com | China | 1970 | 58 |
View Latest Price from Methyl 4-hydroxycyclohexanecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester
17449-76-2
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2021-04-08 | METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
17449-76-2
|
1g | 99% | 100kg/month | Pharmahands (Taizhou) Co., Ltd. | ||
 |
2019-09-02 | METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
17449-76-2
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester
17449-76-2
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
17449-76-2
- 99%
- Pharmahands (Taizhou) Co., Ltd.
-
- METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
17449-76-2
- $7.00
- 99%
- Career Henan Chemical Co
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