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ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE

ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Structure
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE structure
CAS No.
17159-80-7
Chemical Name:
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
Synonyms
ethyl 4-hydroxycyclohexane-1-carboxylate;4-Hydroxycyclohexanecarboxylate;Ai3-28355;Einecs 241-215-1;Ethyl 4-hydroxycyclohexanecarbonate;Ethyl 4-hydroxycyclohexylcarboxylate;ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE;Ethyl4-hydroxycyclohexanecarboxylate,98%;Ethyl 4-hydroxycyclohexanecarboxylate 97%;Ethyl 4-hydroxycyclohexanecarboxylate≥ 99% (assay)
CBNumber:
CB2114589
Molecular Formula:
C9H16O3
Molecular Weight:
172.22
MDL Number:
MFCD00192156
MOL File:
17159-80-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:54:03
Product description Number Pack Size Price
Ethyl 4-hydroxycyclohexanecarboxylate, mixture of cis and trans 98% 386634 5ml $89.9
Ethyl 4-hydroxycyclohexanecarboxylate, mixture of cis and trans 98% 386634 25ml $294
Ethyl 4-hydroxycyclohexanecarboxylate 99+% ≥99%(assay) 237638 5g $192
Ethyl 4-hydroxycyclohexanecarboxylate 99+% ≥99%(assay) 237638 25g $312
Ethyl 4-hydroxycyclohexanecarboxylate 99+% ≥99%(assay) 237638 100g $744
More product size
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ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Properties

Boiling point 127-134 °C0.1 mm Hg(lit.)
Density 1.068 g/mL at 25 °C(lit.)
refractive index n20/D 1.466(lit.)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form liquid
pka 14.98±0.40(Predicted)
Specific Gravity 1.068
Appearance Colorless to light yellow Liquid
Water Solubility Not miscible or difficult to mix in water.
InChI InChI=1S/C9H16O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h7-8,10H,2-6H2,1H3
InChIKey BZKQJSLASWRDNE-UHFFFAOYSA-N
SMILES C1(C(OCC)=O)CCC(O)CC1
CAS DataBase Reference 17159-80-7
FDA UNII D266CGU6M5
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  2918199890
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
0 0

ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 386634 Ethyl 4-hydroxycyclohexanecarboxylate, mixture of cis and trans 98% 17159-80-7 5ml $89.9 2026-04-30 Buy
Sigma-Aldrich 386634 Ethyl 4-hydroxycyclohexanecarboxylate, mixture of cis and trans 98% 17159-80-7 25ml $294 2026-04-30 Buy
Usbiological 237638 Ethyl 4-hydroxycyclohexanecarboxylate 99+% ≥99%(assay) 17159-80-7 5g $192 2026-06-03 Buy
Usbiological 237638 Ethyl 4-hydroxycyclohexanecarboxylate 99+% ≥99%(assay) 17159-80-7 25g $312 2026-06-03 Buy
Usbiological 237638 Ethyl 4-hydroxycyclohexanecarboxylate 99+% ≥99%(assay) 17159-80-7 100g $744 2026-06-03 Buy
Product number Packaging Price Buy
386634 5ml $89.9 Buy
386634 25ml $294 Buy
237638 5g $192 Buy
237638 25g $312 Buy
237638 100g $744 Buy

ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Chemical Properties,Uses,Production

Uses

Ethyl 4-hydroxycyclohexanecarboxylate, cis + trans is used in the synthesis of other chemicals and as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 4145, 1965 DOI: 10.1021/jo01023a039

Synthesis

Ethyl 4-oxocyclohexanecarboxylate

17159-79-4

Ethyl trans-4-Hydroxycyclohexanecarboxylate

3618-04-0

General procedure for the synthesis of ethyl trans-4-hydroxycyclohexanecarboxylate from ethyl 4-oxocyclohexanecarboxylate: ethyl 4-oxocyclohexanecarboxylate (13.5 g, 79 mmol) was dissolved in methanol (150 mL) at 0 °C and sodium borohydride (5.3 g, 140 mmol) was added slowly. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL), followed by extraction with ethyl acetate (150 mL x 1, 50 mL x 2). The organic layers were combined, washed with water (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, ratio 1.5:1 to 1:1) to afford ethyl 4-hydroxycyclohexanecarboxylate (12 g, 88% yield, cis-trans ratio = 3:7) as a clear oil.1H NMR (300 MHz, CDCl3, cis mixture) δ: 4.17-4.08 (m, 2H), 3.90 (bs. 0.3H), 3.68-3.57 (m, 0.7H), 2.42-1.28 (m, 9H), 1.27-1.22 (m, 3H) ppm.(Hydroxyl signal was not observed.)

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8967 - 9004
[2] Organic Process Research and Development, 2010, vol. 14, # 4, p. 883 - 889
[3] Patent: WO2005/80317, 2005, A2. Location in patent: Page/Page column 150
[4] Tetrahedron Letters, 2000, vol. 41, # 39, p. 7567 - 7570
[5] Patent: US5175290, 1992, A

ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Preparation Products And Raw materials

Raw materials

Ethanol Ethyl 4-oxocyclohexanecarboxylate cis-4-Hydroxycyclohexanecarboxylic acid Water Methanol
Sodium borohydride

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Preparation Products

ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Suppliers

Global( 173)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-15225627621 +86-13213167925 jiuyitime@fdachem.com China 16505 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14032 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Accela ChemBio Inc. 		+1-858-6993322 +86-18019713315 info@accelachem.com United States 21189 58
Wuhan Chemwonders Technology Inc. 		027-85778276 info@chemwonders.com CHINA 174 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6361 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
career henan chemical co 		58
Accela ChemBio Inc. 		58
Wuhan Chemwonders Technology Inc. 		58
Xiamen AmoyChem Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58

View Lastest Price from ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 4-hydroxy-cyclohexane-carboxylate pictures 2026-08-07 Ethyl 4-hydroxy-cyclohexane-carboxylate
17159-80-7
 100gm 99%min 100kgs Shanghai Yongzeng Technology Co.,Ltd
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE pictures 2026-08-06 ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
17159-80-7
 1kg 99%min 20tons HANGZHOU HAILAN CHEMICAL CO.,LTD.
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE pictures 2026-08-06 ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
17159-80-7
 1kg 99%min 20tons HANGZHOU HAILAN CHEMICAL CO.,LTD.

ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Spectrum

ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE(17159-80-7)1HNMRETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE(17159-80-7)IR

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Ethyl 4-hydroxycyclohexanecarboxylate, mixture of cis and trans ,98% Ethyl 4-hydroxycyclohexanecarboxylate, Mixture of cis and trans 98% Ethyl 4-hydroxycyclohexanecarbonate Ethyl 4-hydroxycyclohexanecarboxylate≥ 99% (assay) ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Ethyl 4-hydroxycyclohexylcarboxylate Ethyl 4-hydroxycyclohexanecarboxylate,mixture of cis and trans ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE, 9 9%, MIXTURE OF CIS AND TRANS 4-Hydroxycyclohexane-1-carboxylic acid ethyl ester Ethyl 4-hydroxycyclohexanecarboxylate, cis + trans, 97% Ai3-28355 Cyclohexanecarboxylic acid, 4-hydroxy-, ethyl ester Einecs 241-215-1 Ethyl4-hydroxycyclohexanecarboxylate,98% Ethyl 4- Hydroxycyclohexanecarboxylate(Mixture of Cis & Trans isomers) ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE (cis-, trans-mixture) Ethyl 4-hydroxycyclohexanecarboxylate, mixture of cis and trans Ethyl 4-hydroxycyclohexanecarboxylate 97% 4-Hydroxycyclohexanecarboxylate ethyl 4-hydroxycyclohexane-1-carboxylate 124-Hydroxycyclohexanecarboxylic acid (Ethyl ester) 17159-80-7 HOC6H10CO2C2H5 Esters Organic Building Blocks Carbonyl Compounds C8 to C9 Building Blocks C8 to C9 Carbonyl Compounds Esters