4-Chloro-3-fluorophenol
- CAS No.
- 348-60-7
- Chemical Name:
- 4-Chloro-3-fluorophenol
- Synonyms
- 4-CHLORO-3-FLUOROPHENOL;3-fluoro-4-chlorophenol;Phenol, 4-chloro-3-fluoro-;4-Chloro-3-fluorophenol 98%;4-Chloro-3-fluorophenol,98%;4-Chloro-3-fluorophenol >4-Chloro-3-fluorophenol ISO 9001：2015 REACH
- CBNumber:
- CB1491234
- Molecular Formula:
- C6H4ClFO
- Molecular Weight:
- 146.55
- MDL Number:
- MFCD00042583
- MOL File:
- 348-60-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 54-56 °C (lit.) |
|---|---|
| Boiling point | 84 °C/44 mmHg (lit.) |
| Density | 1.3675 (estimate) |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | chloroform: soluble50mg/mL, clear, colorless |
| pka | 8.52±0.18(Predicted) |
| form | Liquid |
| color | Colorless to pale yellow, may discolor to orange during storage |
| BRN | 3236440 |
| InChI | InChI=1S/C6H4ClFO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H |
| InChIKey | XLHYAEBESNFTCA-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(Cl)C(F)=C1 |
| CAS DataBase Reference | 348-60-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-37/39-36/37/39-24/25 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, IRRITANT-HARMFUL | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29081990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Chloro-3-fluorophenol price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 306622 | 4-Chloro-3-fluorophenol 98% | 348-60-7 | 5g | $52.6 | 2026-04-30 | Buy |
| TCI Chemical | C2476 | 4-Chloro-3-fluorophenol >98.0%(GC)(T) | 348-60-7 | 5g | $83 | 2026-04-30 | Buy |
| TCI Chemical | C2476 | 4-Chloro-3-fluorophenol >98.0%(GC)(T) | 348-60-7 | 25g | $342 | 2026-04-30 | Buy |
| Apolloscientific | PC1880G | 4-Chloro-3-fluorophenol 98% | 348-60-7 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC1880G | 4-Chloro-3-fluorophenol 98% | 348-60-7 | 25g | $51 | 2026-06-04 | Buy |
4-Chloro-3-fluorophenol Chemical Properties, Uses, Production
Chemical Properties
White to salmon crystalline solid
Uses
4-Chloro-3-fluorophenol was used in the synthesis of 4-chloro-3-fluoro catechol and 5-Chloro-4-fluoro-2-hydroxyacetophenone.
General Description
4-Chloro-3-fluorophenol is hydroxylated at both ortho positions to yield different products.
Synthesis
![Benzene, 1-chloro-2-fluoro-4-[2-(trimethylsilyl)ethoxy]-](/CAS/20210305/GIF/1338215-43-2.gif)
1338215-43-2
348-60-7
GENERAL METHOD: [2-(Phenoxy)-ethyl]-trimethyl-silane (195 mg, 1.0 mmol) was dissolved in anhydrous DMF (2 mL), cesium fluoride (576 mg, 3.0 mmol) was added, and the reaction was stirred for 1 hr at 60 °C. After the reaction was completed, the reaction mixture was diluted with water and extracted with ethyl acetate (3 × 20 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 92 mg of 4-chloro-3-fluorophenol in 93% yield. The 1H NMR data of the compound was consistent with the standard, confirming its structure.
References
[1] ISHIKAWA Y. 6-Chloro-7-fluoro-4-oxo-4H-chromene-3-carbaldehyde.[J]. Acta crystallographica. Section E, Structure reports online, 2014, 70 Pt 7: o825. DOI:10.1107/S1600536814014706.
[2] VIDYA S. SHIVATARE W. T. Vibronic and cation spectroscopy of selected rotamers of 4-chloro-3-fluorophenol[J]. Molecular Physics, 2014, 112 1: 2397-2406. DOI:10.1080/00268976.2014.904050.
4-Chloro-3-fluorophenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fengcheng Meditech (Tianjin)Co., Ltd | 022-59002498-8008; 15122574756 | info@fcmeditech.com | China | 83 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 4-Chloro-3-fluorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-Chloro-3-fluorophenol
348-60-7
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2019-07-06 | 4-Chloro-3-fluorophenol
348-60-7
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-Chloro-3-fluorophenol
348-60-7
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Chloro-3-fluorophenol
348-60-7
- $1.00
- 99%
- Career Henan Chemical Co
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