2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID
- CAS No.
- 69716-04-7
- Chemical Name:
- 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID
- Synonyms
- 6-Hydroxy-3-benzofuranacetic acid;3-Benzofuranacetic acid, 6-hydroxy-;(6-Hydroxybenzofuran-3-yl)acetic acid;2-(6-Hydroxy-1-benzofuran-3-yl)aceticacid;2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97;2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97-3
- CBNumber:
- CB1506640
- Molecular Formula:
- C10H8O4
- Molecular Weight:
- 192.17
- MDL Number:
- MFCD05273635
- MOL File:
- 69716-04-7.mol
| Product description | Number | Pack Size | Price |
| (6-Hydroxy-1-benzofuran-3-yl)aceticAcid | H808430 | 250mg | $140 |
| 2-(6-Hydroxybenzofuran-3-yl)aceticacid | 0780AC | 5g | $146 |
| 3-Benzofuranaceticacid,6-hydroxy- | CS-M1953 | 25g | $184 |
| 3-Benzofuranaceticacid,6-hydroxy- | CS-M1953 | 1g | $19 |
| 3-Benzofuranaceticacid,6-hydroxy- | CS-M1953 | 5g | $63 |
| More product size | |||
| Melting point | 139-140℃ |
|---|---|
| Boiling point | 251.5±9.0℃ (760 Torr) |
| Density | 1.453±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 105.9±18.7℃ |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.12±0.30(Predicted) |
| Appearance | White to light brown Solid |
| InChI | InChI=1S/C10H8O4/c11-7-1-2-8-6(3-10(12)13)5-14-9(8)4-7/h1-2,4-5,11H,3H2,(H,12,13) |
| InChIKey | ZEMXZWJZCWCPBM-UHFFFAOYSA-N |
| SMILES | O1C2=CC(O)=CC=C2C(CC(O)=O)=C1 |
| CAS DataBase Reference | 69716-04-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| HS Code | 2932990090 | |||||||||
| NFPA 704 |
|
2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H808430 | (6-Hydroxy-1-benzofuran-3-yl)aceticAcid | 69716-04-7 | 250mg | $140 | 2021-12-16 | Buy |
| AK Scientific | 0780AC | 2-(6-Hydroxybenzofuran-3-yl)aceticacid | 69716-04-7 | 5g | $146 | 2021-12-16 | Buy |
| ChemScene | CS-M1953 | 3-Benzofuranaceticacid,6-hydroxy- | 69716-04-7 | 25g | $184 | 2021-12-16 | Buy |
| ChemScene | CS-M1953 | 3-Benzofuranaceticacid,6-hydroxy- | 69716-04-7 | 1g | $19 | 2021-12-16 | Buy |
| ChemScene | CS-M1953 | 3-Benzofuranaceticacid,6-hydroxy- | 69716-04-7 | 5g | $63 | 2021-12-16 | Buy |
2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID Chemical Properties,Uses,Production
Uses
(6-Hydroxy-1-benzofuran-3-yl)acetic Acid is a reactant in the synthesis of dihydrobenzofuran (6-{[4''-(2-ethoxyethoxy)-2'',6''-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl)acetic acid as a potent and orally available GPR40/FFA1 agonist.
Synthesis
25392-41-0
69716-04-7
General procedure for the synthesis of 2-(6-hydroxybenzofuran-3-yl)acetic acid from 4-chloromethyl-7-hydroxychromen-2-one: 1. a mixture of 4-chloromethyl-7-hydroxychromen-2-one (21.0 g, 21.0 mmol) with 1 M aqueous sodium hydroxide solution (1 L) was stirred under reflux conditions for 2 hours. 2. After completion of the reaction, the reaction mixture was acidified with concentrated sulfuric acid. 3. The acidified mixture was extracted with ethyl acetate. 4. The extract was washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. 5. The dried organic phase was concentrated under pressure to give the intermediate (6-hydroxy-1-benzofuran-3-yl)acetic acid (18.0 g, 93.75% yield).
References
[1] Heterocycles, 1995, vol. 41, # 4, p. 647 - 650
[2] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 136-137
[3] Patent: WO2008/1931, 2008, A2. Location in patent: Page/Page column 87
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1538 - 1552
[5] Patent: CN104250239, 2016, B. Location in patent: Paragraph 0292; 0293; 0294
2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
View Lastest Price from 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-08 | 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97
69716-04-7
|
US $2.00 / KG | 1KG | 98% | 100g , 1kg, 5kg , 50kg | Career Henan Chemical Co |
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- 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97
69716-04-7
- US $2.00 / KG
- 98%
- Career Henan Chemical Co
