2-(6-Hydroxy-1-benzofuran-3-yl) acetic acid
- CAS No.
- 69716-04-7
- Chemical Name:
- 2-(6-Hydroxy-1-benzofuran-3-yl) acetic acid
- Synonyms
- 6-Hydroxy-3-benzofuranacetic acid;3-Benzofuranacetic acid, 6-hydroxy-;(6-Hydroxybenzofuran-3-yl)acetic acid;2-(6-Hydroxy-1-benzofuran-3-yl)aceticacid;2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97;2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97-3
- CBNumber:
- CB1506640
- Molecular Formula:
- C10H8O4
- Molecular Weight:
- 192.17
- MDL Number:
- MFCD05273635
- MOL File:
- 69716-04-7.mol
| Melting point | 139-140℃ |
|---|---|
| Boiling point | 251.5±9.0℃ (760 Torr) |
| Density | 1.453±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 105.9±18.7℃ |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.12±0.30(Predicted) |
| Appearance | White to light brown Solid |
| InChI | InChI=1S/C10H8O4/c11-7-1-2-8-6(3-10(12)13)5-14-9(8)4-7/h1-2,4-5,11H,3H2,(H,12,13) |
| InChIKey | ZEMXZWJZCWCPBM-UHFFFAOYSA-N |
| SMILES | O1C2=CC(O)=CC=C2C(CC(O)=O)=C1 |
| CAS DataBase Reference | 69716-04-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| HS Code | 2932990090 | |||||||||
| NFPA 704 |
|
2-(6-Hydroxy-1-benzofuran-3-yl) acetic acid price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR321480 | 2-(6-Hydroxybenzofuran-3-yl)acetic acid >98% | 69716-04-7 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR321480 | 2-(6-Hydroxybenzofuran-3-yl)acetic acid >98% | 69716-04-7 | 25g | $66 | 2026-06-04 | Buy |
| Apolloscientific | OR321480 | 2-(6-Hydroxybenzofuran-3-yl)acetic acid >98% | 69716-04-7 | 100g | $245 | 2026-06-04 | Buy |
| Apolloscientific | OR321480 | 2-(6-Hydroxybenzofuran-3-yl)acetic acid >98% | 69716-04-7 | 500g | $1170 | 2026-06-04 | Buy |
| Matrix Scientific | 199596 | 2-(6-Hydroxy-2,3-dihydrobenzofuran-3-yl)acetic acid | 69716-04-7 | 1.00g | $261 | 2026-05-18 | Buy |
2-(6-Hydroxy-1-benzofuran-3-yl) acetic acid Chemical Properties,Uses,Production
Uses
(6-Hydroxy-1-benzofuran-3-yl)acetic Acid is a reactant in the synthesis of dihydrobenzofuran (6-{[4''-(2-ethoxyethoxy)-2'',6''-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl)acetic acid as a potent and orally available GPR40/FFA1 agonist.
Synthesis
25392-41-0
69716-04-7
General procedure for the synthesis of 2-(6-hydroxybenzofuran-3-yl)acetic acid from 4-chloromethyl-7-hydroxychromen-2-one: 1. a mixture of 4-chloromethyl-7-hydroxychromen-2-one (21.0 g, 21.0 mmol) with 1 M aqueous sodium hydroxide solution (1 L) was stirred under reflux conditions for 2 hours. 2. After completion of the reaction, the reaction mixture was acidified with concentrated sulfuric acid. 3. The acidified mixture was extracted with ethyl acetate. 4. The extract was washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. 5. The dried organic phase was concentrated under pressure to give the intermediate (6-hydroxy-1-benzofuran-3-yl)acetic acid (18.0 g, 93.75% yield).
References
[1] Heterocycles, 1995, vol. 41, # 4, p. 647 - 650
[2] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 136-137
[3] Patent: WO2008/1931, 2008, A2. Location in patent: Page/Page column 87
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1538 - 1552
[5] Patent: CN104250239, 2016, B. Location in patent: Paragraph 0292; 0293; 0294
2-(6-Hydroxy-1-benzofuran-3-yl) acetic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tube Pharmaceutical Co., Ltd. | 021-54338626 18017892860 | sales@tubepharm.com | China | 2709 | 58 |
| Shandong benrite new chemical materials co.,ltd | 0533-2866658 15615638350 | sales@benritechem.com | China | 7016 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Candia Thamtech Company Limited | 0371-86615086 18203638366 0371-86159066 13526786601 | China | 2011 | 60 |
View Lastest Price from 2-(6-Hydroxy-1-benzofuran-3-yl) acetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-08 | 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97
69716-04-7
|
$2.00 | 1KG | 98% | 100g , 1kg, 5kg , 50kg | Career Henan Chemical Co |
-
- 2-(6-HYDROXY-1-BENZOFURAN-3-YL) ACETIC ACID, 97
69716-04-7
- $2.00
- 98%
- Career Henan Chemical Co
