ChemicalBook >> CAS DataBase List >>Boc-4-iodo-L-phenylalanine

Boc-4-iodo-L-phenylalanine

Boc-4-iodo-L-phenylalanine structure

CAS No.: 62129-44-6

Chemical Name:: Boc-4-iodo-L-phenylalanine

Synonyms: BOC-PHE(4-I)-OH;BOC-PHE(4-1)-OH;BOC-L-PHE(4-I);BOC-L-4-IODOPHE;BOC-PHE(P-I)-OH;BOC-PI-L-PHE-OH;BOC-4'-IODO-L-PHE;BOC-L-PHE(4-I)-OH;BOC-P-IODO-PHE-OH;BOC-4-IODO-PHE-OH

CBNumber:: CB1672091

Molecular Formula:: C14H18INO4

Molecular Weight:: 391.2

MDL Number:: MFCD00037119

MOL File:: 62129-44-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:49:20

Request For Quotation

Boc-4-iodo-L-phenylalanine Properties

Melting point	~150 °C (dec.)
alpha	22.5 º (c=1% in ethyl acetate)
Boiling point	475.3±40.0 °C(Predicted)
Density	1.560±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	3.84±0.10(Predicted)
Appearance	White to off-white Solid
optical activity	[α]20/D +22.5±3°, c = 1% in ethyl acetate
Water Solubility	Slightly soluble in water.
Sensitive	Light Sensitive
BRN	4503851
Major Application	peptide synthesis
InChI	InChI=1S/C14H18INO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-4-6-10(15)7-5-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1
InChIKey	JZLZDBGQWRBTHN-NSHDSACASA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(I)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference	62129-44-6(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

WGK Germany

HazardClass

IRRITANT

HS Code

2922498590

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

Boc-4-iodo-L-phenylalanine price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	15346	Boc-Phe(4-I)-OH ≥99.0% (TLC)	62129-44-6	5g	$152	2026-04-30	Buy
TCI Chemical	B6605	Boc-Phe(4-I)-OH	62129-44-6	1G	$24	2026-04-30	Buy
TCI Chemical	B6605	Boc-Phe(4-I)-OH	62129-44-6	5G	$81	2026-04-30	Buy
Usbiological	262048	Boc-4-iodo-L-phenylalanine Asreported	62129-44-6	10g	$470	2026-06-03	Buy
Usbiological	262048	Boc-4-iodo-L-phenylalanine Asreported	62129-44-6	25g	$691	2026-06-03	Buy

Product number	Packaging	Price	Buy
15346	5g	$152	Buy
B6605	1G	$24	Buy
B6605	5G	$81	Buy
262048	10g	$470	Buy
262048	25g	$691	Buy

Boc-4-iodo-L-phenylalanine Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

N-Boc-4-iodo-L-phenylalanine is used as pharmaceutical intermediate. It is also used as a p-iodo phenyl alanine derivative with N-Boc protection.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

1991-81-7

103882-09-3

The reaction was carried out as follows: a 3L three-neck flask was used. (S)-4-Iodo-L-phenylalanine (200.00 g, 687.10 mmol, 1.00 eq.), 1,4-dioxane (1.00 L) and water (1.00 L) were added sequentially to the reaction flask, followed by the addition of sodium hydroxide (68.71 g, 1.72 mol, 2.50 eq.), which led to a gradual clarification of the solution and a slight increase in temperature to 19 °C. The reaction was carried out using a three-necked flask. After the system was cooled to 0-10 °C, di-tert-butyl dicarbonate (254.93 g, 1.17 mol, 268.35 mL, 1.70 eq.) was added slowly dropwise and the reaction temperature was naturally increased to 10-30 °C. The reaction was then carried out at room temperature with the addition of sodium hydroxide (68.71 g, 1.72 mol, 2.50 eq.). After addition, the reaction system was stirred at room temperature (about 30 °C) for 8 hours. The reaction process was monitored by high performance liquid chromatography (HPLC) until the feedstock was fully converted. Subsequently, the temperature of the system was controlled to be below 40 °C and concentrated under reduced pressure to remove 1,4-dioxane. After the reaction mixture was cooled to room temperature (about 25 °C), the reaction was quenched by the addition of 100 mL of water and the pH was adjusted to 1.8-2.0 with 2 M hydrochloric acid. the resulting mixture was extracted three times with ethyl acetate (2 L x 3). The organic phases were combined, washed twice sequentially with saturated brine (1L×2), dried with anhydrous sodium sulfate (200 g), and concentrated under reduced pressure to give a light yellow solid crude product. The crude product was dried in an oven at 40-45 °C to obtain white solid (S)-N-Boc-4-iodo-L-phenylalanine (250.00 g, 626.28 mmol, 93.00% yield, 98% HPLC purity). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.49 (d, J = 7.8 Hz, 2H), 6.88 (d, J = 7.8 Hz, 2H), 5.80 (d, J = 5.9 Hz, 1H), 3.68 (d, J = 5.5 Hz, 1H), 3.00-2.90 (m, 1H), 2.87- 2.75 (m, 1H), 1.35-1.15 (m, 9H).

References

[1] Patent: US2018/155368, 2018, A1. Location in patent: Paragraph 0090-0096
[2] Journal of the American Chemical Society, 2012, vol. 134, # 2, p. 800 - 803
[3] Chemistry - A European Journal, 2013, vol. 19, # 22, p. 7020 - 7041
[4] Journal of Organic Chemistry, 2018, vol. 83, # 8, p. 4525 - 4536
[5] Journal of Organic Chemistry, 1998, vol. 63, # 22, p. 8019 - 8020

Boc-4-iodo-L-phenylalanine Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 4-iodophenylalanine 1,4-Dioxane Water Sodium hydroxide

Preparation Products

Boc-4-iodo-L-phenylalanine Suppliers

Global( 279)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Noventek Pharmaceutical Technology Co.,Ltd	0555-8220886	sales@noventekpharm.com	China	176	58
Suzhou haiyu Biochem Industrial Co., LTD	512-68097639 18013585858	744942877@qq.com	China	915	62
Tianjin Exceedbio Technology Co., Ltd.	022-87899679 13034388368	exceedbio@yeah.net	China	41	55
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD	0838-2809458 13350585791	pharm@biots.cn	China	747	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Shanghai HC Biotech Co., Ltd	021-20227858	sale@hcbiotech.com.cn	China	1173	55
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
Noventek Pharmaceutical Technology Co.,Ltd	58
Suzhou haiyu Biochem Industrial Co., LTD	62
Tianjin Exceedbio Technology Co., Ltd.	55
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Shanghai HC Biotech Co., Ltd	55
Alfa Aesar	84
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Lastest Price from Boc-4-iodo-L-phenylalanine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-07	BOC-4-IODO-L-PHENYLALANINE 62129-44-6		1kG	99%	1000G	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	BOC-D-4-IODOPHENYLALANINE 62129-44-6	$20.00	10KG	98%	100kg	Career Henan Chemical Co

BOC-4-IODO-L-PHENYLALANINE
62129-44-6
99%
Shaanxi Dideu Medichem Co. Ltd

BOC-D-4-IODOPHENYLALANINE
62129-44-6
$20.00
98%
Career Henan Chemical Co

Boc-4-iodo-L-phenylalanine Spectrum

BOC-4-IODO-L-PHENYLALANINE(62129-44-6)¹HNMR

62129-44-6(Boc-4-iodo-L-phenylalanine)Related Search:

TERT-BUTYL 4-(BENZYLAMINO)-3-FLUOROPIPERIDINE-1-CARBOXYLATE Boc-N-beta-Trityl-L-asparagine N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester Boc-L-aspartic acid 4-tert-butyl ester Boc-6-AMinocaproic acid

BOC-NLE-OH DCHA Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate Boc-L-glutamic acid 5-cyclohexyl ester Boc-D-aspartic acid 4-benzyl ester BOC-GLU(OFM)-OH

BOC-PHE-SER-ARG-AMC ACETATE SALT BOC-ORN-OH Boc-Sar-OH tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate N-Boc-L-Phenylalaninol

N-Boc-L-alaninol 4-Iodotoluene 4-Iodo-D-phenylalanine

1of4

N-ALPHA-T-BUTYLOXYCARBONYL-L-4-IODOPHENYLALANINE N-alpha-t-Butyloxycarbonyl-4-iodo-L-phenylalanine BOC-P-IODO-PHENYLALANINE BOC-P-IODO-PHE-OH BOC-L-PHE(4-I) BOC-L-PHE(4-I)-OH BOC-L-4-IODOLPHENYLALANINE BOC-L-4-IODOPHE BOC-L-4-IODOPHENYLALANINE BOC-4'-IODO-L-PHE BOC-4-IODO PHENYLALANINE BOC-4-IODO-PHE-OH (S)-N-ALPHA-T-BUTYLOXYCARBONYL-4-IODOPHENYLALANINE RARECHEM BK PT 0164 (S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOIC ACID N-TBOC-P-IODO-L-PHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-4-IODEO-L-PHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-P-IODO-L-PHENYLALANINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-IODOPHENYLALANINE Boc-4-lodo-Phe-OH Boc-4-Lodo-L-Phenylalanine 4-Iodo-L-phenylalanine, N-BOC protected (Tert-Butoxy)Carbonyl Phe(4-I)-OH 4-Iodo-L-phenylalanine, N-BOC protected 98% N-(tert-butoxycarbonyl)-p-iodo-L-phenylalanine Boc-L-4-Iodo-phe-OH (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-iodophenyl)propanoic acid N-(Tert-Butoxycarbonyl)-4-iodo-(L)-phenylalanine N-Boc-4-Iodo-L-phenylalanine (Boc-Phe(4-I)-OH) ,99% (HPLC) Boc-L-Phe(4-I) –OH Boc-4-Iodo-L-Phenylalanine Boc-4-iodo-L-phenylalanine Boc-p-iodo-L-Phe-OH N-(tert-butyloxycarbonyl)-3-(4-iodophenyl)alanine (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-iodophenyl)propanoic acid, N-(tert-Butoxycarbonyl)-4-iodo-L-phenylalanine L-N-(tert-Butoxycarbonyl)-4-iodophenylalanine Boc-Phe(4-I)-OH >=99.0% (TLC) BOC-S-PHE(4-I)-OH BOC-(S)-2-AMINO-3-(4'-IODOPHENYL)PROPANOIC ACID BOC-PHE(P-I)-OH BOC-PI-L-PHE-OH BOC-P-IODO-L-PHENYLALANINE BOC-P-IODO-L-PHE-OH (S)-Boc-2-amino-3-(4-iodophenyl)propionic acid Boc-4-iodo-L-phenylalanine≥ 98% (HPLC) (2S)-3-(4-iodophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-iodo- BOC-4-IODO-L-PHENYLALANINE USP/EP/BP (2S)-3-(4-iodophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Fampridine Impurity 26 (3-Aminopyridin-4-ol) BOC-PHE(4-1)-OH BOC-PHE(4-I)-OH Boc-4-iodo-L-phenylalanine 62129-44-6 CH33COCONHCHCOOHCH2C6H4I C14H18IHO4 Specialty Synthesis Unnatural Amino Acid Derivatives Phenylalanine Derivatives Peptide Synthesis