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GALAXOLIDE

GALAXOLIDE Structure
GALAXOLIDE structure
CAS No.
1222-05-5
Chemical Name:
GALAXOLIDE
Synonyms
HEXAMETHYLINDANOPYRAN;GALAXOLIDE PURE;HHCB;ABBALIDE;Galoxolide;Galaxolide Dpg;GALAXOLIDE(HHCB);GALAXOLIDE 50 IPM;4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene;1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA[G]-2-BENZOPYRAN
CBNumber:
CB1706143
Molecular Formula:
C18H26O
Molecular Weight:
258.4
MDL Number:
MFCD00072199
MOL File:
1222-05-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-02 11:11:20
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GALAXOLIDE Properties

Melting point 57-58°
Boiling point 304 °C(lit.)
Density 1.044 g/mL at 25 °C(lit.)
vapor pressure 0.073Pa at 25℃
refractive index n20/D 1.5215(lit.)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Colorless to Light yellow
Odor at 100.00 %. strong diffusive sweet floral musk
Odor Type musk
Water Solubility 1.65mg/L at 25℃
Henry's Law Constant 7.6×10-2 mol/(m3Pa) at 25℃, HSDB (2015)
Major Application cleaning products
cosmetics
food and beverages
personal care
Cosmetics Ingredients Functions PERFUMING
FRAGRANCE
InChI 1S/C18H26O/c1-11-14-10-16-15(9-13(14)7-8-19-11)17(3,4)12(2)18(16,5)6/h9-12H,7-8H2,1-6H3
InChIKey YWMTVUUYOAIDBC-UHFFFAOYSA-N
SMILES CC1(C)C(C)C(C)(C)C2=CC3=C(C(C)COC3)C=C21
LogP 5.3 at 25℃
CAS DataBase Reference 1222-05-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 14170060AT
EPA Substance Registry System 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (1222-05-5)
UNSPSC Code 85151701
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
Signal word  Warning
Hazard statements  H315-H317-H320-H335+H336-H410
Precautionary statements  P273-P391-P501-P261-P264-P271-P272-P280-P302+P352+P333+P313+P363-P304+P340+P312-P305+P351+P338+P337+P313-P403+P233-P405
Hazard Codes  Xi,N
Risk Statements  38-50/53
Safety Statements  26-36-61
RIDADR  UN 3082 9 / PGIII
WGK Germany  3
TSCA  TSCA listed
HS Code  2932.99.7000
HazardClass  9
PackingGroup  III
Storage Class 10 - Combustible liquids
Hazard Classifications Aquatic Acute 1
Aquatic Chronic 1
Hazardous Substances Data 1222-05-5(Hazardous Substances Data)
Toxicity LD50 skin in rat: > 5gm/kg
REACH Registrations Active
NFPA 704
0
2 0

GALAXOLIDE price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CRM30806 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran certified reference material, TraceCERT®, mixture of isomers, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland 1222-05-5 50 mg $206 2026-04-30 Buy
Sigma-Aldrich W520608 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran solution 50% in diethyl phthalate 1222-05-5 sample $54.6 2023-01-07 Buy
Sigma-Aldrich W520608 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran solution 50% in diethyl phthalate 1222-05-5 1kg $83.8 2022-05-15 Buy
TCI Chemical G0415 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (ca. 50% in Diethyl Phthalate) 1222-05-5 25g $36 2026-04-30 Buy
TCI Chemical G0415 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (ca. 50% in Diethyl Phthalate) 1222-05-5 250g $171 2026-04-30 Buy
Product number Packaging Price Buy
CRM30806 50 mg $206 Buy
W520608 sample $54.6 Buy
W520608 1kg $83.8 Buy
G0415 25g $36 Buy
G0415 250g $171 Buy

GALAXOLIDE Chemical Properties, Uses, Production

Chemical Properties

Clear Colourless to Pale Yellow Oil

Chemical Properties

4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran is a viscous liquid with a musk-like odor. It is one of the most frequently used synthetic, artificial musk fragrances.The starting material for its synthesis is 1,1,2,3,3-pentamethylindane, which is prepared by cycloaddition of tert-amylene to α-methylstyrene. The pentamethylindane is hydroxyalkylated with propylene oxide in a Friedel–Crafts reaction using aluminum chloride as a catalyst (analogous to the synthesis of phenylethyl alcohol from benzene and ethylene oxide . Ring closure of the resulting 1,1,2,3,3-pentamethyl-5-(β-hydroxyisopropyl)indane is accomplished with paraformaldehyde and a lower aliphatic alcohol via the acetal or with paraformaldehyde and a carboxylic acid anhydride via the acylate.
The commercial product is diluted with solvents (e.g., diethyl phthalate, isopropyl myristate, benzyl benzoate) to make it less viscous. It is alkali-stable and does not discolor in light. Therefore, it is a popular ingredient of perfume compositions for soaps, detergents, and cosmetics and is used in large amounts.

Uses

Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents.

Definition

ChEBI: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.

General Description

1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran is an isochromone with a strong musk odor, commonly used in fragrances.

Flammability and Explosibility

Not classified

Trade name

Galaxolide® (IFF), Astromusk (Agan),Musk YingHai (YingHai).

Synthesis

The synthesis of Galaxolide epimers proceeds via a catalytic route starting from pentamethylindane under mild conditions, featuring asymmetric hydrogenation as a key step[1]. The final stage involves reducing the derived acid to an alcohol, followed by ring closure with paraformaldehyde in the presence of sulfuric acid to yield the product in 78% yield[1].

References

[1]Ciappa, A., Matteoli, U., & Scrivanti, A. (2002). Asymmetric catalysis in fragrance chemistry: a new synthesis of Galaxolide. Tetrahedron: Asymmetry, 13(20), 2193–2195. https://doi.org/10.1016/s0957-4166(02)00538-4

GALAXOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

GALAXOLIDE Suppliers

Global Suppliers ( 334)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
TCI AMERICA 800-4238616 sales@tciamerica.com Americas 23636 75
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Shanghai T&W Pharmaceutical Co., Ltd. 58
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
TCI Europe 75
TCI AMERICA 75
9ding chemical ( Shanghai) Limited 55

View Latest Price from GALAXOLIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Galaxolide pictures 2026-06-30 Galaxolide
1222-05-5
 1KG 97.5% 100000KGS Shaanxi Dideu New Materials Co. Ltd
GALAXOLIDE pictures 2026-05-28 GALAXOLIDE
1222-05-5
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
GALAXOLIDE pictures 2026-03-20 GALAXOLIDE
1222-05-5
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
  • Galaxolide pictures
  • Galaxolide
    1222-05-5
  • $0.00
  • 97.5%
  • Shaanxi Dideu New Materials Co. Ltd
  • GALAXOLIDE pictures
  • GALAXOLIDE
    1222-05-5
  • $2.00-5.00
  • 99%
  • Hebei Chuanghai Biotechnology Co,.LTD
  • GALAXOLIDE pictures
  • GALAXOLIDE
    1222-05-5
  • $10.00
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

GALAXOLIDE Spectrum

GALAXOLIDE(1222-05-5)1HNMR

1222-05-5 (GALAXOLIDE) Related Search:

2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole Methyl tetrahydrophthalic anhydride Musk ketone Isochroman 2-(4-tert-Butylphenyl)ethanol
1,1,3,3,5-Pentamethyl-4,6-dinitroindane GALAXOLIDE 2-(3,4-Dimethylphenyl)ethanol 5-Hydroxymethylindane 2,5-Dimethylphenethyl alcohol
4-n-Butylphenethyl alcohol 2,4-Dimethylphenethylalcohol97% 1-(4-Isobutylphenyl)ethanol 1,1,3,3,5-pentamethylindan p-isopropylphenethyl alcohol
1-(2,4-Dimethylphenyl)ethanol 4-(tert-Butyl)-alpha-methylbenzyl alcohol 1,1,4,6-Tetramethylindane

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1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA[G]-2-BENZOPYRAN 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYL-CYCLOPENTA-GAMMA-2-BENZOPYRAN 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta(g)-2-benzopyra GALAXOLIDE GALAXOLIDE 50 GALAXOLIDE 50 BB Pearlide 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-.alpha.-2-benzopyran 4,6,6,7,8,8-hexamethyl-1,3,4,7-tetrahydrocyclopenta[g]isochromene HHCB (Galaxolide) Hexahydro-4,6,6,7,8,8-hexamethyl cyclopenta-γ-2-benzopyran Cyclopentag-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl- 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran solution HEXAHYDROHEXAMETHYLCYCLOPENTA(G)-2-BENZOPYRAN 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLINDINO[5,6-C]PYRAN HEXAHYDRO-4,6,6,7,8-HEXAMETHYLCYCLOPOPENTA-GAMMA-2-BENZOPYRAN PEARLIDE PURE Cyclopenta[g]-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,7,8,8-hexamethyl- GALAXOLIDE 50% IN B.B. GALAXOLIDE 50% IN D.E.P. GALAXOLIDE 50% IN I.P.M. GALAXOLIDE 70% IN D.E.P. 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexaMethylcyclopenta[g]-2-benzopyrane Galaxolide (solution 50% in diethyl phthalate) 1,3,4,6,7,8-Hexahydro-4,6,6,8,8,8-hexamethylcyclopenta-2-benzopyran hexamethylindeno(5,6-c)pyran GALAXOLIDE / 4,6,6,7,8,8-Hexamethyl- 1,3,4,6,7,8- hexahydrocyclopenta[g]isochro 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexaMethylcyclopenta[g]-2-benzopyran (ca. 50% in Diethyl Phthalate) Galaxolide (Mixture of Diastereomers) HHCB (Galaxoli 8-Hexahydro-4 8-hexamethylcyclopenta[g]-2-benzopyran Galaxolide Abbalide 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta[g]-2-benzopyra 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno(5,6 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno(5,6-c)pyran 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5, Galoxolide Musk50 Hexahydromethyl cyclopentabenzopyran (~50%diethyl phthalate) GALAXOLIDE USP/EP/BP Musk Yinghai Pure Galaxolide standard solution musk gx 100% musk gx 50% in DEP musk gx 50% in DPG musk gx 50% in BB musk gx 50% in IPM Factory Supply Galaxolide Price?1222-05-5?in Stock High Purity CAS?1222-05-5?Galaxolide 50% Pure DEP Jiale musk50% Jiale musk Galaxolide (musk g pure) 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno(5,6-c)pyr... Galaxolide (Mixture of Diastereomers) (>80%) Musk Pure(Galaxolide) Galaxolide (Techn.) in isooctane LA14213000CY HHCB 10μg/mLin Cyclohexane