- Galaxolide
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-
2026-06-30
- CAS:1222-05-5
- Min. Order: 1KG
- Purity: 97.5%
- Supply Ability: 100000KGS
- GALAXOLIDE
-
- $5.00
-
2026-05-28
- CAS:1222-05-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000kg
- GALAXOLIDE
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- $10.00
-
2026-03-20
- CAS:1222-05-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | GALAXOLIDE Basic information |
| Product Name: | GALAXOLIDE | | Synonyms: | 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA[G]-2-BENZOPYRAN;1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYL-CYCLOPENTA-GAMMA-2-BENZOPYRAN;1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta(g)-2-benzopyra;GALAXOLIDE;GALAXOLIDE 50;GALAXOLIDE 50 BB;Pearlide;1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-.alpha.-2-benzopyran | | CAS: | 1222-05-5 | | MF: | C18H26O | | MW: | 258.4 | | EINECS: | 214-946-9 | | Product Categories: | Aromatics;Detergents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Alphabetical Listings;Flavors and Fragrances;G-H | | Mol File: | 1222-05-5.mol |  |
| | GALAXOLIDE Chemical Properties |
| Melting point | 57-58° | | Boiling point | 304 °C(lit.) | | density | 1.044 g/mL at 25 °C(lit.) | | vapor pressure | 0.073Pa at 25℃ | | refractive index | n20/D 1.5215(lit.) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | color | Colorless to Light yellow | | Odor | at 100.00 %. strong diffusive sweet floral musk | | Odor Type | musk | | Water Solubility | 1.65mg/L at 25℃ | | Henry's Law Constant | 7.6×10-2 mol/(m3Pa) at 25℃, HSDB (2015) | | Major Application | cleaning products
cosmetics
food and beverages
personal care | | Cosmetics Ingredients Functions | PERFUMING
FRAGRANCE | | InChI | 1S/C18H26O/c1-11-14-10-16-15(9-13(14)7-8-19-11)17(3,4)12(2)18(16,5)6/h9-12H,7-8H2,1-6H3 | | InChIKey | YWMTVUUYOAIDBC-UHFFFAOYSA-N | | SMILES | CC1(C)C(C)C(C)(C)C2=CC3=C(C(C)COC3)C=C21 | | LogP | 5.3 at 25℃ | | CAS DataBase Reference | 1222-05-5(CAS DataBase Reference) | | EPA Substance Registry System | 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (1222-05-5) |
| Hazard Codes | Xi,N | | Risk Statements | 38-50/53 | | Safety Statements | 26-36-61 | | RIDADR | UN 3082 9 / PGIII | | WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 2932.99.7000 | | HazardClass | 9 | | PackingGroup | III | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Aquatic Acute 1
Aquatic Chronic 1 | | Hazardous Substances Data | 1222-05-5(Hazardous Substances Data) | | Toxicity | LD50 skin in rat: > 5gm/kg |
| | GALAXOLIDE Usage And Synthesis |
| Chemical Properties | Clear Colourless to Pale Yellow Oil | | Chemical Properties | 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran is a viscous liquid with
a musk-like odor. It is one of the most frequently used synthetic, artificial musk
fragrances.The starting material for its synthesis is 1,1,2,3,3-pentamethylindane,
which is prepared by cycloaddition of tert-amylene to α-methylstyrene. The
pentamethylindane is hydroxyalkylated with propylene oxide in a Friedel–Crafts
reaction using aluminum chloride as a catalyst (analogous to the synthesis
of phenylethyl alcohol from benzene and ethylene oxide . Ring
closure of the resulting 1,1,2,3,3-pentamethyl-5-(β-hydroxyisopropyl)indane
is accomplished with paraformaldehyde and a lower aliphatic alcohol via the
acetal or with paraformaldehyde and a carboxylic acid anhydride via the
acylate.
The commercial product is diluted with solvents (e.g., diethyl phthalate, isopropyl
myristate, benzyl benzoate) to make it less viscous. It is alkali-stable and does not
discolor in light. Therefore, it is a popular ingredient of perfume compositions for
soaps, detergents, and cosmetics and is used in large amounts. | | Uses | Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents. | | Definition | ChEBI: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics. | | General Description | 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran is an isochromone with a strong musk odor, commonly used in fragrances. | | Flammability and Explosibility | Not classified | | Trade name | Galaxolide® (IFF), Astromusk (Agan),Musk YingHai (YingHai). | | Synthesis | The synthesis of Galaxolide epimers proceeds via a catalytic route starting from pentamethylindane under mild conditions, featuring asymmetric hydrogenation as a key step[1]. The final stage involves reducing the derived acid to an alcohol, followed by ring closure with paraformaldehyde in the presence of sulfuric acid to yield the product in 78% yield[1]. | | References | [1]Ciappa, A., Matteoli, U., & Scrivanti, A. (2002). Asymmetric catalysis in fragrance chemistry: a new synthesis of Galaxolide. Tetrahedron: Asymmetry, 13(20), 2193–2195. https://doi.org/10.1016/s0957-4166(02)00538-4
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| | GALAXOLIDE Preparation Products And Raw materials |
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