Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Musk ketone

Musk ketone

Musk ketone Structure
Musk ketone structure
CAS No.
81-14-1
Chemical Name:
Musk ketone
Synonyms
KETONE MOSCHUS;(-)-Licarin A;Ethanone, 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-;MOSCHUS;Musk ketone 0;2-Acetyl-5-tert-butyl-4,6-dinitro-1,3-dimethylbenzene;4'-tert-butyl-2',6'-dimethyl-3',5'-dinitroacetophenone;1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-ethanon;Ketone musk;MUSK KETONE
CBNumber:
CB5458527
Molecular Formula:
C14H18N2O5
Molecular Weight:
294.3
MDL Number:
MFCD00024271
MOL File:
81-14-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-28 18:27:15
Product description Number Pack Size Price
4'-TERT-BUTYL-2',6'-DIMETHYL-3',5'-DINITROACETOPHENONE AldrichCPR S342963 1 unit $197
Musk ketone solution 100 μg/mL in acetonitrile, analytical standard 46377 2ml $75
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone Asreported 266361 10g $232
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone ≥97% 97% 233665 1g $163
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone Asreported 266361 25g $343
More product size
Request For Quotation

Musk ketone Properties

Melting point 134-137 °C
Boiling point 436.08°C (rough estimate)
Density 1.2051 (rough estimate)
vapor pressure 0.001Pa at 25℃
refractive index 1.5110 (estimate)
Flash point 2 °C
storage temp. 2-8°C
solubility DMSO : 250 mg/mL (849.47 mM; Need ultrasonic)
form Solid
color White to off-white
Odor at 10.00 % in benzyl benzoate. fatty musk soapy dry floral powdery
Odor Type musk
biological source synthetic
Water Solubility Insoluble (<0.1 g/100 mL at 20 ºC)
BRN 2062638
Henry's Law Constant 3.0×100 mol/(m3Pa) at 25℃, Lee et al. (2012)
Stability Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
Major Application environmental
Cosmetics Ingredients Functions FRAGRANCE
PERFUMING
InChI 1S/C14H18N2O5/c1-7-10(9(3)17)8(2)13(16(20)21)11(14(4,5)6)12(7)15(18)19/h1-6H3
InChIKey WXCMHFPAUCOJIG-UHFFFAOYSA-N
SMILES CC(=O)c1c(C)c(c(c(c1C)[N+]([O-])=O)C(C)(C)C)[N+]([O-])=O
LogP 4.24 at 25℃
CAS DataBase Reference 81-14-1(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) MUSK, KETONE
EWG's Food Scores 3-4
FDA UNII 483V3E1L6J
NIST Chemistry Reference 2,6-Dimethyl-3,5-dinitro-4-t-butylacetophenone(81-14-1)
EPA Substance Registry System Musk ketone (81-14-1)
UNSPSC Code 85151701
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)
GHS02,GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H225-H302-H312-H319-H332-H351-H410
Precautionary statements  P210-P280-P305+P351+P338-P273-P281-P501
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xn,N
Risk Statements  11-20/21/22-36-50/53-40
Safety Statements  16-36/37-61-60-46
RIDADR  UN1648 3/PG 2
WGK Germany  2
RTECS  KM5775841
TSCA  TSCA listed
HS Code  2914790060
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
Hazardous Substances Data 81-14-1(Hazardous Substances Data)
Toxicity Both the acute oral LD50 in rats and the acute dermal LD50 in rabbits exceeded 10 g/kg (Fogleman, 1970).
REACH Registrations Active

Musk ketone price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S342963 4'-TERT-BUTYL-2',6'-DIMETHYL-3',5'-DINITROACETOPHENONE AldrichCPR 81-14-1 1 unit $197 2026-04-30 Buy
Sigma-Aldrich 46377 Musk ketone solution 100 μg/mL in acetonitrile, analytical standard 81-14-1 2ml $75 2022-05-15 Buy
Usbiological 266361 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone Asreported 81-14-1 10g $232 2026-06-03 Buy
Usbiological 233665 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone ≥97% 97% 81-14-1 1g $163 2026-06-03 Buy
Usbiological 266361 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone Asreported 81-14-1 25g $343 2026-06-03 Buy
Product number Packaging Price Buy
S342963 1 unit $197 Buy
46377 2ml $75 Buy
266361 10g $232 Buy
233665 1g $163 Buy
266361 25g $343 Buy

Musk ketone Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystal powde

Chemical Properties

It forms yellowish crystals with a sweet, very persistent, slightly animal musk odor.Musk ketone is prepared by Friedel–Crafts acetylation of 1,3-dimethyl-5-tert-butylbenzene and nitration of the resulting 2,6- dimethyl-4-tert-butylacetophenone with nitric acid.
Musk ketone is widely used as a fixative in blossom and fantasy compositions.

Occurrence

Has apparently not been reported to occur in nature.

Uses

Musk ketone is used as fragrance and fixative in after-shave lotions, perfumes, ete.

Preparation

Nitration of the corresponding benzene derivative (Bedoukian, 1967).

Definition

ChEBI: 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone is an aromatic ketone.

General Description

Light yellow crystalline solid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Health Hazard

Several studies provided convincing evidence of lack of a genotoxic potential for musk ketone (MK). However, MK was identified as a strong inducer of phase I enzymes in rodents and a cogenotoxicant in vitro in human derived cells in rather low doses, suggesting that exposure to MK might increase the susceptibility to health hazards caused by carcinogens in humans.

Fire Hazard

Flash point data is not available for Musk ketone, however, Musk ketone is probably combustible.

Flammability and Explosibility

Not classified

Potential Exposure

As a result of its inherently low biodegradability, musk ketone (MK) has been detected in the aquatic environment (surface water, sediments, edible fish). Moreover, it has been shown that MK concentrates in human fatty tissue and breast milk, indicating that humans are constantly exposed.

Purification Methods

Purify the ketone by recrystallisation from MeOH. It has a strong odour of musk and is used in perfumery. [Fuson et al. J Org Chem 12 587 1947, Beilstein 7 IV 808.]

Musk ketone synthesis

98-19-1
81-14-1
Synthesis of Musk ketone from 1-tert-Butyl-3,5-dimethylbenzene

Musk ketone Preparation Products And Raw materials

Raw materials

1-tert-Butyl-3,5-dimethylbenzene 2-Methyl-1-propanol 4'-tert-Butylacetophenone m-Xylene Zinc chloride
Ferric chloride

1of2

Preparation Products

Musk ketone Suppliers

Global( 355)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou AniKare Pharmatech Co., Ltd.
+86-0519-8359-8696 sales@anikare.com China 9993 58
Shanghai Yongzeng Technology Co.,Ltd
+86-021-65281118 +86-13818947575 sales@yongzchem.com China 144 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		0531-68652808 18953170293 sales@sdzschem.com China 2921 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Jinan Qinmu Fine Chemical Co.,Ltd. 		18660799346 sales@qinmuchem.com China 1006 58
Supplier Advantage
Changzhou AniKare Pharmatech Co., Ltd.
58
Shanghai Yongzeng Technology Co.,Ltd
58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Jinan Qinmu Fine Chemical Co.,Ltd. 		58

View Lastest Price from Musk ketone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,5-Dinitro-4-t-butyl-2,6-dimethylacetophenone pictures 2026-08-21 3,5-Dinitro-4-t-butyl-2,6-dimethylacetophenone
81-14-1
 20kg 99%min 2000kgs Shanghai Yongzeng Technology Co.,Ltd
Ketone musk pictures 2026-08-03 Ketone musk
81-14-1
 $500.00 1KG 99% 1000KG Henan Boweixin Biotechnology Co., Ltd.
Musk ketone pictures 2026-07-27 Musk ketone
81-14-1
 $53.00 99.85% 10g TargetMol Chemicals Inc.
  • Ketone musk pictures
  • Ketone musk
    81-14-1
  • $500.00
  • 99%
  • Henan Boweixin Biotechnology Co., Ltd.
  • Musk ketone pictures
  • Musk ketone
    81-14-1
  • $53.00
  • 99.85%
  • TargetMol Chemicals Inc.

Musk ketone Spectrum

Musk ketone(81-14-1)1HNMR

81-14-1(Musk ketone)Related Search:

N,N-Dimethyldodecylamine tert-Butyl methyl ether Muscone ETHANE Dimethyl ether
Musk xylene 3-Nitroacetophenone Dimethyl fumarate L-PICEIN Buprofezin
4-Nitroacetophenone Dimethyl phthalate Dimethyl sulfide tert-Butyldimethylsilyl chloride Dimethyl sulfoxide
N,N-Dimethylformamide tert-Butyl hydroperoxide Acetophenone

1of4

2-Acetyl-5-tert-butyl-4,6-dinitro-1,3-dimethylbenzene 3',5'-Dinitro-4'-tert-butyl-2',6'-dimethylacetophenone 3, 5-Dinitro-4-t-butyl-2, 6-dimethylacetophenone Ketone Moschus,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Musk ketone Musk ketone,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Ketone Moschus Ketone Moschus >=97.0% (N) 1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-ethanon 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-ethanon 1-Acetyl-4-tert-butyl-2,6-dimethyl-3,5-dinitrobenzene 2-acetyl-5-tert-butyl-4,6-dinitroxylene 3,5-Dinitro-2,6-dimethyl-4-tert-butyl acetophenone MUSK KETONE 98+% 4-Aceto-3,5-dimethyl-2,6-dinitro-tert-butylbenzene 2,6-DIMETHYL-3,5-DINITRO-4-TERT-BUTYLACETOPHENONE(MUSKKETONE) 3’,5’-dinitro-2’,6’-dimethyl-4’-tert-butylacetophenone MOSCHUS KETON 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]ethanone 2',6'-Dimethyl-3',5'-dinitro-4'-tert-butylacetophenone 3-METHYLCYCLOPENTADECANONE (D,L-MUSCONE) 4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Ketone Moschus Methylcyclopentadecanone 4’-tert-butyl-2’,6’-dimethyl-3’,5’-dinitro-acetophenon 4’-tert-Butyl-2’,6-dimethyl-3’,5’dmnitroacetophenone 4-t-Butyl-2,6-dimethyl-3,5-dinitroacetophenone 4-tert-Butyl-2,6-dimethyl-3,5-dinitroactophenone Acetophenone, 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitro- Acetyl-dinitro-butyl-xylene Dinitro-tert-butylxylyl methyl ketone Ethanone,1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]- Ketone musk MUSK KETONE 2,6-DINITRO-3,5-DIMETHYL-4-ACETYL-TERT-BUTYLBENZENE 1-[4-(TERT-BUTYL)-2,6-DIMETHYL-3,5-DINITROPHENYL]ETHAN-1-ONE 1-(4-TERT-BUTYL-2,6-DIMETHYL-3,5-DINITRO-PHENYL)-ETHANONE 4-TERT-BUTYL-3,5-DINITRO-2,6-DIMETHYL ACETOPHENONE 4-TERT-BUTYL-2,6-DIMETHYL-3,5-DINITROACETOPHENONE Synthetic Musk ketone Musk ketone Solution in Methanol, 100μg/mL Musk ketone USP/EP/BP Best Price CAS 81-14-1 Musk Ketone Powder (-)-Licarin A Musk ketone in acetonitrile Musk ketone in isooctane Musk ketone 10.0 μg/ml Cyclohexane Musk ketone, 10 mM in DMSO Musk ketone 10 μg/mL in Cyclohexane MOSCHUS Musk ketone (Standard) 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitroacetophenone Ethanone, 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]- KETONE MOSCHUS Musk ketone 0 81-14-1 81-41-1 CH3COC6HC4H9CH3NO22 CH3C15H27O CH33CC6NO22CH32COCH3 C13 to C14