1-Naphthhydrazide
- CAS No.
- 43038-45-5
- Chemical Name:
- 1-Naphthhydrazide
- Synonyms
- 1-NAPHTHOHYDRAZIDE;SKL728;AKOS BC-1515;1-phthhydrazide;1-Naphthhydrazide;A-NAPHTHOYLHYDRAZINE;1-Naphthoylhydrazine;1-NAPHTHOIC HYDRAZIDE;SPECS AN-068/40186625;1-Naphthohydrazide>
- CBNumber:
- CB1706406
- Molecular Formula:
- C11H10N2O
- Molecular Weight:
- 186.21
- MDL Number:
- MFCD00016804
- MOL File:
- 43038-45-5.mol
- MSDS File:
- SDS
| Melting point | 166-168°C |
|---|---|
| Density | 1.232±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 12.65±0.30(Predicted) |
| color | White to Light yellow |
| BRN | 2966714 |
| InChI | InChI=1S/C11H10N2O/c12-13-11(14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,12H2,(H,13,14) |
| InChIKey | VMFUMDXVTKTZQY-UHFFFAOYSA-N |
| SMILES | C1(C(NN)=O)=C2C(C=CC=C2)=CC=C1 |
| CAS DataBase Reference | 43038-45-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HS Code | 2928.00.2500 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
1-Naphthhydrazide price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | N0776 | 1-Naphthohydrazide >98.0%(GC)(T) | 43038-45-5 | 1g | $195 | 2026-04-30 | Buy |
| Biosynth | FN69859 | alpha-Naphthoylhydrazine | 43038-45-5 | 25g | $150 | 2026-06-04 | Buy |
| Matrix Scientific | 006585 | 1-Naphthhydrazide | 43038-45-5 | 10.00g | $64 | 2026-05-18 | Buy |
| Matrix Scientific | 006585 | 1-Naphthhydrazide | 43038-45-5 | 25.00g | $107 | 2026-05-18 | Buy |
| Matrix Scientific | 006585 | 1-Naphthhydrazide | 43038-45-5 | 100.00g | $371 | 2026-05-18 | Buy |
1-Naphthhydrazide Chemical Properties, Uses, Production
Synthesis
2459-24-7
43038-45-5
General procedure for the synthesis of 1-naphthylhydrazine from methyl 1-naphthalenecarboxylate: Methyl 1-naphthalenecarboxylate (0.52 g, 2.8 mmol) was dissolved in 15 mL of 98% hydrazine hydrate, fitted with an air condenser tube, and the reaction was stirred for 8 h at 110 °C. The reaction was carried out in the presence of an air condenser tube. Upon completion of the reaction, the mixture was cooled to room temperature and the precipitated crystalline solid was collected by filtration. The resulting solid was dissolved in ethyl acetate (EtOAc), and the organic phase was washed sequentially with water, saturated sodium bicarbonate (NaHCO3) solution and brine, and then concentrated under reduced pressure to remove the solvent. The product was purified by column chromatography (elution gradient: hexane/ethyl acetate 1:1; hexane/ethyl acetate 1:2) to give 0.38 g (73% yield) of white crystalline solid. Thin layer chromatography (TLC) Rf = 0.53 (unfolding agent: chloroform/methanol 10:1). Melting point 166-169 °C (literature value 166 °C).IR (KBr, cm-1): νmax 3280 (N-H), 1658 (C=O), 1606, 1588, 1524, 1261, 955.1H NMR (300 MHz, DMSO-d6): δ 9.69 (s, 1H, NH), 8.35-8.10 (m. 1H, Ar-H), 8.05-7.88 (m, 2H, Ar-H), 7.63-7.26 (m, 4H, Ar-H), 4.60 (s, 2H, NH2).13C NMR (75 MHz, DMSO-d6): δ 168.2 (C=O), 133.6, 133.3, 130.2, 130.1, 128.4, 128.4 126.8, 126.4, 125.6, 125.6, 125.2 (Ar-C).
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 120, p. 97 - 110
[2] Journal of the American Chemical Society, 2010, vol. 132, # 20, p. 6900 - 6901
[3] Chemistry - A European Journal, 2011, vol. 17, # 30, p. 8294 - 8298
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 11, p. 3615 - 3621
[5] RSC Advances, 2015, vol. 5, # 37, p. 28996 - 29001
1-Naphthhydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
1-Naphthhydrazide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
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