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D(-)Prolinol

D(-)Prolinol Structure
D(-)Prolinol structure
CAS No.
68832-13-3
Chemical Name:
D(-)Prolinol
Synonyms
D-PROLINOL;(R)-(-)-PROLINOL;(R)-(-)-2-PYRROLIDINEMETHANOL;(R)-1-PYRROLIDIN-2-YL-METHANOL;D-Pro-ol;H-D-PRO-OL;H-D-PROLINOL;D(-)PROLINOL;(R)-PROLINOL;D-Pro-ol(oil)
CBNumber:
CB1748417
Molecular Formula:
C5H11NO
Molecular Weight:
101.15
MDL Number:
MFCD00064321
MOL File:
68832-13-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-23 18:03:16
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D(-)Prolinol Properties

alpha -31 º (c=1, toluene)
Boiling point 74-76 °C2 mm Hg(lit.)
Density 1.036 g/mL at 20 °C(lit.)
refractive index n20/D 1.485
Flash point 187 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly), Toluene (Slightly)
form Solution
pka 14.77±0.10(Predicted)
color Clear to slightly hazy colorless to amber
Specific Gravity 1.025
optical activity [α]20/D 31°, c = 1 in toluene
Sensitive Air Sensitive
BRN 1523669
InChI 1S/C5H11NO/c7-4-5-2-1-3-6-5/h5-7H,1-4H2/t5-/m1/s1
InChIKey HVVNJUAVDAZWCB-RXMQYKEDSA-N
SMILES OC[C@H]1CCCN1
CAS DataBase Reference 68832-13-3(CAS DataBase Reference)
FDA UNII H52Z235V6Y
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25-26/36
RIDADR  NA 1993 / PGIII
WGK Germany  3
F  3-10-23
Hazard Note  Irritant/Air Sensitive
HazardClass  IRRITANT
HS Code  29339900
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 1

D(-)Prolinol price More Price(98)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 281697 (R)-(?)-2-Pyrrolidinemethanol 99% 68832-13-3 1g $37.6 2026-04-30 Buy
Sigma-Aldrich 281697 (R)-(?)-2-Pyrrolidinemethanol 99% 68832-13-3 5g $96.7 2026-04-30 Buy
TCI Chemical P1274 D-Prolinol >99.0%(GC)(T) 68832-13-3 1g $30 2026-04-30 Buy
TCI Chemical P1274 D-Prolinol >99.0%(GC)(T) 68832-13-3 5g $97 2026-04-30 Buy
Strem Chemicals 07-1895 (R)-(-)-2-Pyrrolidinemethanol, 99% (D-Prolinol) 68832-13-3 1g $80 2026-04-30 Buy
Product number Packaging Price Buy
281697 1g $37.6 Buy
281697 5g $96.7 Buy
P1274 1g $30 Buy
P1274 5g $97 Buy
07-1895 1g $80 Buy

D(-)Prolinol Chemical Properties, Uses, Production

Synthesis

There are two main methods for the synthesis of D(-)Prolinol: (1) indirect reduction method: using D-proline as raw material, esterification and neutralization are performed, followed by reduction with NaBH4; (2) direct reduction method: D-proline is directly reduced with AlLiH4. The former is cumbersome and has a low yield (42.6%); the latter is demanding, requiring low-temperature ice bath addition, resulting in high cost and a dark product color. The authors used a reduction system of NaBH4 with added auxiliary I2 to directly reduce D-proline to D-proline (see figure below), which is low-cost, of good quality, stable, easy to operate, and readily industrialized.

 Synthesis of 68832-13-3

Chemical Properties

Colorless to light yellow liqui

Uses

(2R)-2-Pyrrolidinemethanol is used in the synthesis of potent selective 5-HT7 antagonists.

Definition

ChEBI: The D-enantiomer of prolinol. Metabolite observed in cancer metabolism.

D(-)Prolinol Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine (R)-2-(Aminomethyl)-1-N-Boc-pyyrolidine 2-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Pyrrolidine, 2-[(1,1-dimethylethoxy)methyl]-, (R)- (9CI) (R)-(+)-1-Amino-2-(methoxymethyl)pyrrolidine

D(-)Prolinol Suppliers

Global Suppliers ( 451)
Supplier Tel Email Country ProdList Advantage
Shandong Welt Chem. Co .Ltd 531-87153728 13805401165 xufeng192@126.com China 106 58
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Welt Chem. Co.,Ltd. 531-87153728 13805401165 xufeng192@126.com China 5858 58
YuChen Biological Medicine 0535-7295056 15692356085 sdycc1234@163.com China 133 58
Yanggu Rongke Trading Co., Ltd 15863541132 18366413387@163.com China 5723 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Shandong Welt Chem. Co .Ltd 58
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Welt Chem. Co.,Ltd. 58
YuChen Biological Medicine 58
Yanggu Rongke Trading Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
future industrial shanghai co., ltd 65
Alfa Aesar 84

View Latest Price from D(-)Prolinol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D-Pro-ol pictures 2026-09-15 D-Pro-ol
68832-13-3
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
D-Prolinol pictures 2026-09-15 D-Prolinol
68832-13-3
 1kg 98%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
D(-)Prolinol pictures 2026-09-02 D(-)Prolinol
68832-13-3
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd
  • D-Pro-ol pictures
  • D-Pro-ol
    68832-13-3
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd
  • D-Prolinol pictures
  • D-Prolinol
    68832-13-3
  • $0.00
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • D(-)Prolinol pictures
  • D(-)Prolinol
    68832-13-3
  • $5.00
  • 99%
  • Henan Fengda Chemical Co., Ltd

D(-)Prolinol Spectrum

D(-)Prolinol(68832-13-3)1HNMRD(-)Prolinol(68832-13-3)RamanD(-)Prolinol(68832-13-3)IR

68832-13-3 (D(-)Prolinol) Related Search:

Povidone iodine Pyrrolidine phytosphingosine Fosfomycin tromethamine Ketorolac tromethamine
N-Vinyl-2-pyrrolidone N-Methyl-2-pyrrolidone D-Proline Dexketoprofen trometamol cis-4-Hydroxy-D-proline
Hydrogenated Cottonseed Oil Polyvinylpyrrolidone Fmoc-D-proline Ethyl D-(-)-pyroglutamate (S)-(+)-2-(Methoxymethyl)pyrrolidine
Methyl-2-pyrrolidone Boc-D-Pro-OSu N-Benzyloxycarbonyl-D-proline

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(+)-D-PROLINOL D(-)PROLINOL H-D-PROLINOL H-D-PRO-OL (R)-(-)-2-(Hydroxymethyl)pyrrolidine (R)-(-)-2-Pyrrolidinemethanol (R)-(-)-PyrrolidinemethanolD-Prolinol D-Pro-ol(oil) (2R)-PYRROLIDIN-2-YLMETHANOL 2-Pyrrolidinemethanol, (2R)- D-Prolinol (oil)≥ 99% (HPLC, Chiral purity) D-Prolinol,99%e.e. (R)-(-)-2-(HYDROXYMETHYL)PYRROLIDINE R-2-HYDROXYMETHYL-PYRROLIDINE R-2-PYRROLIDINEMETHANOL (R)-PYRROLIDINE-2-METHANOL (R)-PROLINOL D-prolinol, (R)-2-Hydroxymethylpyrrolidine 2-[(2,7,7-trimethylbicyclo[2.2.1]hept-1-yl)methyl]cyclohexanone (R)-(-)-2-Pyrrolidinemethanol, 99% (D-Prolinol) (R)-2-Hydroxymethylpyrrolidone (R)-(-)-Prolinol, 98+% (R)-(-)-2-(Hydroxymethyl)pyrrolidine, D-Prolinol D-Pro-ol (2R)-2-Pyrrolidinemethanol D-(2-Pyrrolidinyl)methanol D-2-(Hydroxymethyl)pyrrolidine D-2-Pyrrolidinemethanol D-Prolinol,(R)-()-2-(Hydroxymethyl)pyrrolidine, (R)-()-2-Pyrrolidinemethanol (R)-()-2-Pyrrolidinemethanol,(R)-()-2-(Hydroxymethyl)pyrrolidine, D-Prolinol (2R)-(-)-2-(Hydroxymethyl)pyrrolidine 95% -(-)-2-Pyrrolidinemethano (R)-Pyrrolidin-2-yl-Methanol D-(-)-Prolinol, (2R)-(Pyrrolidin-2-yl)methanol (R)-(-)-2-PyrrolidineMethano D(-)Prolinol,99% (R)-(-)-2-Pyrrolidine Methanol, 98%, 98% pyrrolidin-1-ylmethanol H-D-Pro-ol(oil) CAS:68832-13-3 D-Prolinol> (R)-(-)-2-PyrroL Avanafil Impurity 55 D(-)Prolinol USP/EP/BP D-Prolinol extrapure, 98% AvafilImpurity44 (R)-pyrrolidine-2-ylmethanol (-)-2-Pyrrolidinemethanol (R)-(?)-2-Pyrrolidinemethanol D-Prolinol 98% (2R)-(-)-2-(Hydroxymethyl)pyrrolidine (R)-1-PYRROLIDIN-2-YL-METHANOL (R)-(-)-2-PYRROLIDINEMETHANOL (R)-(-)-PROLINOL D-PROLINOL 68832-13-3 Asymmetric Synthesis Amino Alcohols Peptide Synthesis