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(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine structure

CAS No.: 60419-23-0

Chemical Name:: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

Synonyms: (R)-1-(2-Pyrrolidinylmeth;(2R)-2-(1-Pyrrolidinylmethyl)pyrrolidine;(R)-1-(Pyrrolidin-2-ylMethyl)pyrrolidine;1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine;(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine;1-(((R)-pyrrolidin-2-yl)methyl)pyrrolidine;(R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE;Pyrrolidine, 1-[(2R)-2-pyrrolidinylmethyl]-;1-[[(2R)-pyrrolidin-2-yl]methyl]pyrrolidine;(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 2HCl

CBNumber:: CB0140975

Molecular Formula:: C9H18N2

Molecular Weight:: 154.25

MDL Number:: MFCD04117879

MOL File:: 60419-23-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:48

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(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Properties

Boiling point	265.8±0.0 °C(Predicted)
Density	0.975±0.06 g/cm3(Predicted)
refractive index	1.4850 to 1.4890
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	clear liquid
pka	10.91±0.10(Predicted)
color	Colorless to Light yellow
InChI	InChI=1S/C9H18N2/c1-2-7-11(6-1)8-9-4-3-5-10-9/h9-10H,1-8H2/t9-/m1/s1
InChIKey	YLBWRMSQRFEIEB-SECBINFHSA-N
SMILES	N1(C[C@H]2CCCN2)CCCC1
CAS DataBase Reference	60419-23-0

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Danger

Hazard statements

H302-H318

Precautionary statements

P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310

Hazard Codes

Risk Statements

HS Code

2933998090

NFPA 704

	2
2		0

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P1925	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine >98.0%(GC)(T)	60419-23-0	1g	$167	2023-06-20	Buy
TRC	P999240	(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine	60419-23-0	10mg	$45	2021-12-16	Buy
TRC	P999240	(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine	60419-23-0	50mg	$60	2021-12-16	Buy
Apolloscientific	OR913029	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 95%	60419-23-0	1g	$120	2021-12-16	Buy
Chem-Impex	41084	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine,98%(GC) 98%(GC)	60419-23-0	1G	$169.12	2021-12-16	Buy

Product number	Packaging	Price	Buy
P1925	1g	$167	Buy
P999240	10mg	$45	Buy
P999240	50mg	$60	Buy
OR913029	1g	$120	Buy
41084	1G	$169.12	Buy

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Chemical Properties,Uses,Production

Synthesis

Pyrrolidine, 1-[(2R)-2-pyrrolidinylcarbonyl]- (9CI)

144243-45-8

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

60419-23-0

Using (+)-Cbz-D-proline (1.5 g, 6 mmol) as raw material, EDC (2.3 g, 12 mmol), HOBt (800 mg, 6 mmol), TEA (1.5 mL), and pyrrolidine (853 mg, 12 mmol) were sequentially added in DMF (20 mL) and the reaction was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was diluted with water and sodium bicarbonate and extracted with dichloromethane (3 x 20 mL). The organic phases were combined, concentrated and purified by silica gel column chromatography to afford benzyl (R)-2-(pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylate. The resulting benzyl ester of (R)-2-(pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylate was dissolved in methanol, Pd/C catalyst was added and hydrogenated at room temperature for 20 h. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give pyrrolidin-1-yl-(R)-pyrrolidin-2-yl- methanone. Pyrrolidin-1-yl-(R)-pyrrolidin-2-yl-methanone (1.2 g, 7.1 mmol) was dissolved in THF (10 mL) at 0 °C and B2H6 (10 mL, 10 mmol) was added slowly. The reaction mixture was heated to reflux and reacted for 16 hours. Upon completion of the reaction, the reaction solution was acidified with HCl and concentrated to remove the solvent. The residue was adjusted to pH 10 with 2N NaOH and extracted with dichloromethane solution containing 5% methanol. The organic phases were combined, concentrated and purified by silica gel column chromatography to afford the target product (R)-1-(2-pyrrolidinylmethyl)pyrrolidine 800 mg in 73% yield.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4334 - 4343
[2] Patent: WO2004/76412, 2004, A2. Location in patent: Page 98
[3] Patent: US2003/125370, 2003, A1
[4] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 50

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine synthesis

Synthesis of (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine from Pyrrolidine, 1-[(2R)-2-pyrrolidinylcarbonyl]- (9CI)

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Preparation Products And Raw materials

Raw materials

(S)-tert-butyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate Pyrrolidine, 1-[(5-oxo-2-pyrrolidinyl)carbonyl]-, (R)- (9CI) Pyrrolidine, 1-[(2R)-2-pyrrolidinylcarbonyl]- (9CI) D(-)Prolinol N-Boc-D-proline

1-PYRROLIDINECARBONYL CHLORIDE (R)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE D-Pyroglutamic acid L-Proline D-Proline

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Preparation Products

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Suppliers

Global( 97)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9644	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323658 +86-18168183658	sales1@artkmedchem.com	China	39002	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39927	58

Supplier	Advantage
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Nextpeptide Inc	58
changzhou huayang technology co., ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Suzhou ARTK Medchem Co., Ltd.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 60419-23-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2019-08-08	1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine 60419-23-0	US $3.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine
60419-23-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine
60419-23-0
US $3.00 / KG
99%
Career Henan Chemical Co

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Spectrum

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine(60419-23-0)¹HNMR

60419-23-0((R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine)Related Search:

Polyvinylpyrrolidone 1-Methylpyrrolidine N-Methyl-2-pyrrolidone Pyrrolidine (R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

PHA-665752 METHYL-2-PYRROLIDONE H-VAL-D-PRO-PRO-OH BOC-ALA-ALA-D-TRP-PHE-D-PRO-PRO-NLE-NH2 ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-D-PRO-PRO-TRP-NH2

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(R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE (R)-1-(Pyrrolidin-2-ylMethyl)pyrrolidine (R)-1-(2-Pyrrolidinylmethyl)pyrrolidine dihydrochloride Pyrrolidine, 1-[(2R)-2-pyrrolidinylmethyl]- (2R)-2-(1-Pyrrolidinylmethyl)pyrrolidine (R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE 98% (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine98% (R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 2HCl (R)-1-(2-Pyrrolidinylmeth 1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine 1-(((R)-pyrrolidin-2-yl)methyl)pyrrolidine (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine> (R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine dihydrochloride (R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 1-[[(2R)-pyrrolidin-2-yl]methyl]pyrrolidine (R)-1-(Pyrrolidin-2-ylmethyl)pyrrolidine - [P90712] 60419-23-0