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(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine structure

CAS No.: 60419-23-0

Chemical Name:: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

Synonyms: (R)-1-(2-Pyrrolidinylmeth;(2R)-2-(1-Pyrrolidinylmethyl)pyrrolidine;(R)-1-(Pyrrolidin-2-ylMethyl)pyrrolidine;1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine;(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine;1-(((R)-pyrrolidin-2-yl)methyl)pyrrolidine;(R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE;Pyrrolidine, 1-[(2R)-2-pyrrolidinylmethyl]-;1-[[(2R)-pyrrolidin-2-yl]methyl]pyrrolidine;(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 2HCl

CBNumber:: CB0140975

Molecular Formula:: C9H18N2

Molecular Weight:: 154.25

MDL Number:: MFCD04117879

MOL File:: 60419-23-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:18:20

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(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Properties

Boiling point	265.8±0.0 °C(Predicted)
Density	0.975±0.06 g/cm3(Predicted)
refractive index	1.4850 to 1.4890
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	clear liquid
pka	10.91±0.10(Predicted)
color	Colorless to Light yellow
InChI	InChI=1S/C9H18N2/c1-2-7-11(6-1)8-9-4-3-5-10-9/h9-10H,1-8H2/t9-/m1/s1
InChIKey	YLBWRMSQRFEIEB-SECBINFHSA-N
SMILES	N1(C[C@H]2CCCN2)CCCC1
CAS DataBase Reference	60419-23-0

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Danger

Hazard statements

H302-H318

Precautionary statements

P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310

Hazard Codes

Risk Statements

HS Code

2933998090

NFPA 704

	2
2		0

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P1925	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine >98.0%(GC)(T)	60419-23-0	1g	$167	2023-06-20	Buy
Usbiological	288373	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Asreported	60419-23-0	250mg	$306	2026-06-03	Buy
Usbiological	288373	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Asreported	60419-23-0	500mg	$420	2026-06-03	Buy
Usbiological	288373	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Asreported	60419-23-0	1g	$566	2026-06-03	Buy
Usbiological	288373	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Asreported	60419-23-0	2g	$762	2026-06-03	Buy

Product number	Packaging	Price	Buy
P1925	1g	$167	Buy
288373	250mg	$306	Buy
288373	500mg	$420	Buy
288373	1g	$566	Buy
288373	2g	$762	Buy

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Chemical Properties, Uses, Production

Synthesis

Pyrrolidine, 1-[(2R)-2-pyrrolidinylcarbonyl]- (9CI)

144243-45-8

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

60419-23-0

Using (+)-Cbz-D-proline (1.5 g, 6 mmol) as raw material, EDC (2.3 g, 12 mmol), HOBt (800 mg, 6 mmol), TEA (1.5 mL), and pyrrolidine (853 mg, 12 mmol) were sequentially added in DMF (20 mL) and the reaction was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was diluted with water and sodium bicarbonate and extracted with dichloromethane (3 x 20 mL). The organic phases were combined, concentrated and purified by silica gel column chromatography to afford benzyl (R)-2-(pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylate. The resulting benzyl ester of (R)-2-(pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylate was dissolved in methanol, Pd/C catalyst was added and hydrogenated at room temperature for 20 h. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give pyrrolidin-1-yl-(R)-pyrrolidin-2-yl- methanone. Pyrrolidin-1-yl-(R)-pyrrolidin-2-yl-methanone (1.2 g, 7.1 mmol) was dissolved in THF (10 mL) at 0 °C and B2H6 (10 mL, 10 mmol) was added slowly. The reaction mixture was heated to reflux and reacted for 16 hours. Upon completion of the reaction, the reaction solution was acidified with HCl and concentrated to remove the solvent. The residue was adjusted to pH 10 with 2N NaOH and extracted with dichloromethane solution containing 5% methanol. The organic phases were combined, concentrated and purified by silica gel column chromatography to afford the target product (R)-1-(2-pyrrolidinylmethyl)pyrrolidine 800 mg in 73% yield.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4334 - 4343
[2] Patent: WO2004/76412, 2004, A2. Location in patent: Page 98
[3] Patent: US2003/125370, 2003, A1
[4] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 50

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine synthesis

Synthesis of (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine from Pyrrolidine, 1-[(2R)-2-pyrrolidinylcarbonyl]- (9CI)

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Preparation Products And Raw materials

Raw materials

(S)-tert-butyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate Pyrrolidine, 1-[(5-oxo-2-pyrrolidinyl)carbonyl]-, (R)- (9CI) Pyrrolidine, 1-[(2R)-2-pyrrolidinylcarbonyl]- (9CI) D(-)Prolinol N-Boc-D-proline

1-Pyrrolidinecarbonyl chloride (R)-tert-Butyl 2-(tosyloxymethyl)pyrrolidine-1-carboxylate D-Pyroglutamic acid L-Proline D-Proline

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Preparation Products

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Suppliers

Global Suppliers ( 102)

Supplier	Tel	Email	Country	ProdList	Advantage
Wulechem Co., Ltd.	13761914825	wulesian@wulechem.com	China	285	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7916	65
Shanghai Holy Biohemdeviser Co., Ltd	021-61551100		China	443	57
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9884	58
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80
TCI AMERICA	800-4238616	sales@tciamerica.com	Americas	23636	75

Supplier	Advantage
Wulechem Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Pure Chemistry Scientific Inc.	62
Daicel Chiral Technologies (China)CO.,LTD	65
Shanghai Holy Biohemdeviser Co., Ltd	57
T&W GROUP	58
TOKYO CHEMICAL INDUSTRY CO., LTD.	80
TCI AMERICA	75

View Latest Price from (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 60419-23-0	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2019-08-08	1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine 60419-23-0	$3.00	1KG	99%	100kg	Career Henan Chemical Co

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine
60419-23-0
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine
60419-23-0
$3.00
99%
Career Henan Chemical Co

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Spectrum

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine(60419-23-0)¹HNMR

60419-23-0 ((R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine) Related Search:

Polyvinylpyrrolidone Pyrrolidine 1-Methylpyrrolidine N-Methyl-2-pyrrolidone (R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine Methyl-2-pyrrolidone Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2 Boc-Arg-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-D-Pro-Pro-Trp-NH2

H-Val-D-Pro-Pro-OH GR 94800 1-(2-Pyrrolidinylmethyl)pyrrolidine Bz-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2 (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

(D)-H-GRKKRRQRRRPPRPKRPTTLNLFPQVRRSQDT-NH2 Fmoc-D-Pro-D-Pro-D-Pro-D-Pro-OH trifluoroacetate NPC 17731, [Pro-3,4-3H]-

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(R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE (R)-1-(Pyrrolidin-2-ylMethyl)pyrrolidine (R)-1-(2-Pyrrolidinylmethyl)pyrrolidine dihydrochloride Pyrrolidine, 1-[(2R)-2-pyrrolidinylmethyl]- (2R)-2-(1-Pyrrolidinylmethyl)pyrrolidine (R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE 98% (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine98% (R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 2HCl (R)-1-(2-Pyrrolidinylmeth 1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine 1-(((R)-pyrrolidin-2-yl)methyl)pyrrolidine (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine> (R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine dihydrochloride (R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 1-[[(2R)-pyrrolidin-2-yl]methyl]pyrrolidine (R)-1-(Pyrrolidin-2-ylmethyl)pyrrolidine - [P90712] (R)-1-(pyrrolidin-2-ylmethyl)pyrrolidine dihydrochloride 60419-23-0