3-Hydroxyadamantane-1-acetic acid
- CAS No.
- 17768-36-4
- Chemical Name:
- 3-Hydroxyadamantane-1-acetic acid
- Synonyms
- Nsc252898;AKOS BC-0174;CHEMBRDG-BB 4013907;IFLAB-BB F3052-0016;LABOTEST-BB LT00077093;(3-Hydroxyadamantanyl)acetic acid;3-HYDROXYADAMANTANE-1-ACETIC ACID;1-Hydroxy-3-adamantaneacetic acid;(3-HYDROXY-1-ADAMANTYL)ACETIC ACID;1-Adamantaneacetic acid, 3-hydroxy-
- CBNumber:
- CB1759169
- Molecular Formula:
- C12H18O3
- Molecular Weight:
- 210.27
- MDL Number:
- MFCD00167797
- MOL File:
- 17768-36-4.mol
- MSDS File:
- SDS
| Melting point | 125-129 °C |
|---|---|
| Boiling point | 375.3±15.0 °C(Predicted) |
| Density | 1.329 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 4.72±0.10(Predicted) |
| form | powder to crystaline |
| color | White to Almost white |
| InChI | InChI=1S/C12H18O3/c13-10(14)6-11-2-8-1-9(3-11)5-12(15,4-8)7-11/h8-9,15H,1-7H2,(H,13,14) |
| InChIKey | JFMDWSCOQLUOCZ-UHFFFAOYSA-N |
| SMILES | C12(CC(O)=O)CC3CC(CC(O)(C3)C1)C2 |
| CAS DataBase Reference | 17768-36-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29162090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-Hydroxyadamantane-1-acetic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 678651 | 3-Hydroxyadamantane-1-acetic acid 97% | 17768-36-4 | 1g | $122 | 2023-06-20 | Buy |
| TCI Chemical | H1414 | 3-Hydroxy-1-adamantaneacetic Acid >97.0%(T) | 17768-36-4 | 1g | $51 | 2026-04-30 | Buy |
| TCI Chemical | H1414 | 3-Hydroxy-1-adamantaneacetic Acid >97.0%(T) | 17768-36-4 | 5g | $205 | 2026-04-30 | Buy |
| Apolloscientific | OR315786 | 3-Hydroxy-1-adamantane acetic acid >98% | 17768-36-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR315786 | 3-Hydroxy-1-adamantane acetic acid >98% | 17768-36-4 | 5g | $41 | 2026-06-04 | Buy |
3-Hydroxyadamantane-1-acetic acid Chemical Properties, Uses, Production
Chemical Properties
Light yellow powder
Uses
3-Hydroxyadamantane-1-acetic acid is a derivative of adamantane. Its crystal structure has been analyzed through X-ray diffraction, revealing stabilization through intermolecular O-H...O hydrogen bonds that form a chain. The application of adamantane and its derivatives is widespread in medicine. For example, adamantaneamine has demonstrated efficacy in inhibiting influenza A virus exuviation and in easing Parkinsonian symptoms (Lu et al., 1996).
Synthesis
4942-47-6
17768-36-4
General procedure for the synthesis of 3-hydroxy-1-adamantaneacetic acid from 1-adamantaneacetic acid: adamantanecarboxylic acid (1a-1s, 3.5 g) was added in batches to a mixture comprising 2.5-3 or 7 equivalents of MnO2 and 2.5-14 mL of 93% H2SO4, pre-cooled to -30 °C, with the reaction maintained at a temperature of less than 25 °C, under vigorous stirring. The reaction mixture was maintained at this temperature for 0.5-24 hours and subsequently treated with cold water under ice bath cooling. The precipitate was collected by filtration and washed with a small amount of water and butan-1-ol. The product was extracted with butan-1-ol (5 x 2 mL). For the isolation of the products 2j-21 and 2q-2s, it was necessary to adjust the mixture to pH 3-4 with 30% aqueous sodium hydroxide solution prior to extraction. all organic phases were combined, washed sequentially with water, sodium bicarbonate solution, and water, and then dried by azeotropic distillation. Finally, the solvent was removed under reduced pressure on a rotary evaporator and the target product 3-hydroxy-1-adamantaneacetic acid was purified by recrystallization.
References
[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 6, p. 785 - 790
[2] Zh. Org. Khim., 2016, vol. 52, # 6, p. 800 - 805,6
[3] Chemische Berichte, 1968, vol. 101, p. 564 - 573
[4] Russian Journal of Organic Chemistry, 2017, vol. 53, # 7, p. 971 - 976
3-Hydroxyadamantane-1-acetic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Maohuan Chemical Co.Ltd> | 13996103726 | info@bschem.com | China | 172 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Sichuan Zhongbang Pharma CO.，LTD | 0830-0830-2585019 13679670161 | sales2@zhongbangst.com | China | 105 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jinxiang Chemical (Danyang) Products Co., Ltd. | 025-86819862 13913839793 | nancyzong@jinchemical.com | China | 97 | 74 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Latest Price from 3-Hydroxyadamantane-1-acetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 3-Hydroxyadamantane-1-acetic acid
17768-36-4
|
1KG | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2025-04-04 | (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID
17768-36-4
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-11-17 | (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID
17768-36-4
|
$100.00 | 1KG | 99% | 1000kg | Longyan Tianhua Biological Technology Co., Ltd |
-
- 3-Hydroxyadamantane-1-acetic acid
17768-36-4
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID
17768-36-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID
17768-36-4
- $100.00
- 99%
- Longyan Tianhua Biological Technology Co., Ltd
