Dimethyl pyridine-2,5-dicarboxylate
- CAS No.
- 881-86-7
- Chemical Name:
- Dimethyl pyridine-2,5-dicarboxylate
- Synonyms
- Acifluorfen Impurity 7;dimethyl isocinchomeronate;Dimethyl-2,5-pyridinecarboxylate;Dimethy1-2.5-pyridineaarbanylate;2,5-Bis(methoxycarbonyl)pyridine;DIMETHYL 2,5-PYRIDINEDICARBOXYLATE;METHYL 6-METHOXYCARBONYL NICOTINATE;2,5-pyridine-dimethyl dicarboxylate;Dimethyl pyridine-2,5-dicarboxylate;2,5-dimethyl pyridine-2,5-dicarboxylate
- CBNumber:
- CB1767704
- Molecular Formula:
- C9H9NO4
- Molecular Weight:
- 195.17
- MDL Number:
- MFCD00034767
- MOL File:
- 881-86-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 213-217 °C(lit.) |
|---|---|
| Boiling point | 302.9±22.0 °C(Predicted) |
| Density | 1.231±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Dichloromethane, Ethyl Acetate |
| pka | -0.35±0.10(Predicted) |
| Appearance | White to off-white Solid |
| Water Solubility | Soluble in Dichloromethane and Ethyl Acetate. Insoluble in water. |
| BRN | 172251 |
| InChI | InChI=1S/C9H9NO4/c1-13-8(11)6-3-4-7(10-5-6)9(12)14-2/h3-5H,1-2H3 |
| InChIKey | TUGSJNQAIMFEDY-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC=C(C(OC)=O)C=C1 |
| CAS DataBase Reference | 881-86-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
Dimethyl pyridine-2,5-dicarboxylate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 540234 | Dimethyl 2,5-pyridine dicarboxylate 97% | 881-86-7 | 25g | $106 | 2026-04-30 | Buy |
| Matrix Scientific | 083391 | Dimethyl pyridine-2,5-dicarboxylate | 881-86-7 | 25.00g | $55 | 2026-05-18 | Buy |
| Matrix Scientific | 083391 | Dimethyl pyridine-2,5-dicarboxylate | 881-86-7 | 100.00g | $168 | 2026-05-18 | Buy |
| Synthonix | D26049 | Dimethyl pyridine-2,5-dicarboxylate 97% | 881-86-7 | 1g | $28 | 2026-05-06 | Buy |
| Synthonix | D26049 | Dimethyl pyridine-2,5-dicarboxylate 97% | 881-86-7 | 5g | $32 | 2026-05-06 | Buy |
Dimethyl pyridine-2,5-dicarboxylate Chemical Properties,Uses,Production
Uses
Intermediate for the synthesis of potent antitumor agents.
Uses
It is the intermediate in the synthesis of potent antitumor agents.
General Description
Dimethyl 2,5-pyridine dicarboxylate can be prepared from 2,5-pyridinedicarboxylic acid.
Synthesis
67-56-1
100-26-5
881-86-7
Oxalyl chloride (60.96 g, 480 mmol) was slowly added dropwise over 20 min to a suspension of 2,5-pyridinedicarboxylic acid (20 g, 120 mmol) in dichloromethane (396 mL) and N,N-dimethylformamide (DMF, 6.6 mL). The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was concentrated under reduced pressure by rotary evaporator and the residue was azeotroped with toluene to remove residual water. The residue was dissolved in methanol (276 mL) pre-cooled to 0 °C and stirred for 15 min. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was dissolved in ethyl acetate. The organic phase was washed sequentially with saturated aqueous sodium bicarbonate solution, deionized water and saturated brine. Some of the product was collected as a white precipitate. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2,5-pyridinedicarboxylate as a white solid (Yield: 22.93 g, 98% yield). It was analyzed by liquid chromatography-mass spectrometry (LCMS, Method B) with a retention time (R t) of 2.48 min and a molecular ion peak [M + H] + = 196.
References
[1] Patent: WO2009/85983, 2009, A1. Location in patent: Page/Page column 65
[2] Molecules, 2014, vol. 19, # 1, p. 102 - 121
[3] European Journal of Organic Chemistry, 2013, # 3, p. 541 - 549
[4] Tetrahedron Letters, 2005, vol. 46, # 6, p. 967 - 969
[5] Patent: US2007/231300, 2007, A1. Location in patent: Page/Page column 13-14
Dimethyl pyridine-2,5-dicarboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Guangchen Pharmaceutical Technology Co., Ltd | 18563726319 | 2845578351@qq.com | China | 7026 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| New Energy Chemicals | 0515-82159099 13770142076 | info@njuchem.com | China | 251 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
View Lastest Price from Dimethyl pyridine-2,5-dicarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | Dimethyl-2,5-pyridinecarboxylate
881-86-7
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | Dimethyl 2,5-pyridinedicarboxylate
881-86-7
|
$1.00 | 1kg | 95%-99% | Career Henan Chemical Co |
-
- Dimethyl-2,5-pyridinecarboxylate
881-86-7
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Dimethyl 2,5-pyridinedicarboxylate
881-86-7
- $1.00
- 95%-99%
- Career Henan Chemical Co
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