- Ethylmalonic acid
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- $29.00 / 1mL
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2026-04-20
- CAS:601-75-2
- Min. Order:
- Purity: 99.88%
- Supply Ability: 10g
- Ethylmalonic acid
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- $0.00 / 1kg
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2025-04-04
- CAS:601-75-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- ETHYLMALONIC ACID
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- $1.00 / 1KG
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2019-07-06
- CAS:601-75-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
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| | ETHYLMALONIC ACID Basic information |
| | ETHYLMALONIC ACID Chemical Properties |
| Melting point | 112-114 °C (lit.) | | Boiling point | 292.77°C (rough estimate) | | density | 1.5633 (rough estimate) | | refractive index | 1.4016 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | pK1:2.90(0);pK2:5.55(+1) (25°C) | | form | Solid | | color | Off-White | | Water Solubility | Soluble in water, methanol (very faint turbidity), and ethanol. | | BRN | 774334 | | InChI | 1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9) | | InChIKey | UKFXDFUAPNAMPJ-UHFFFAOYSA-N | | SMILES | CCC(C(O)=O)C(O)=O | | CAS DataBase Reference | 601-75-2(CAS DataBase Reference) | | NIST Chemistry Reference | Ethylmalonic acid(601-75-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29171990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | ETHYLMALONIC ACID Usage And Synthesis |
| Chemical Properties | white to faintly pink crystalline powder | | Uses | Ethylmalonic acid is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. | | Definition | ChEBI: Ethylmalonic acid is a dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group. It has a role as a human metabolite. It is a dicarboxylic acid and a dicarboxylic fatty acid. It is functionally related to a malonic acid. It is a conjugate acid of an ethylmalonate and an ethylmalonate(2-). | | Synthesis | Step 2: In a 250 mL three-necked flask equipped with a magnetic stirrer, a dosing funnel and a thermometer, monoethyl malonate potassium salt (17.77 g, 104.49 mmol) was dissolved in 18 mL of water. The reaction mixture was cooled in an ice bath and 8 mL of concentrated hydrochloric acid (about 2 mL) was added slowly and dropwise. Upon completion of the reaction, the mixture was filtered to remove the resulting KCl precipitate and the precipitate was washed with ether (3 x 50 mL). The filtrate was separated and the aqueous phase was further extracted with ether (3 x 50 mL). All ether phases were combined, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure to give the colorless oily product ethylmalonic acid (13.45 g, 82% overall yield in two steps). | | IC 50 | Human Endogenous Metabolite | | References | [1] Patent: US6780887, 2004, B1 |
| | ETHYLMALONIC ACID Preparation Products And Raw materials |
| Raw materials | Hydrochloric acid-->Water-->Diethyl ethylmalonate-->Ethyl potassium malonate | | Preparation Products | 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol-->3-[1,1'-Biphenyl]-4-yl-1,2,3,4-tetrahydro-1-naphthol-->2-ETHYLACRYLIC ACID 98-->Ethylmalonic acid dibutyl ester-->Benzenepropanoic acid, β-amino-3,5-dichloro-, ethyl ester |
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