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4-tert-Butylphenol

4-tert-Butylphenol Structure
4-tert-Butylphenol structure
CAS No.
98-54-4
Chemical Name:
4-tert-Butylphenol
Synonyms
PTBP;P-TERT-BUTYLPHENOL;PARA-TERT-BUTYLPHENOL;4-t-Butylphenol;4-(1,1-DIMETHYLETHYL)PHENOL;t-Butylphenol;p-terc.Butylfenol;Phenol, 4-tert-butyl-;Propargite IMpurity B;4-tert-Butylphenol, extra pure
CBNumber:
CB1854749
Molecular Formula:
C10H14O
Molecular Weight:
150.22
MDL Number:
MFCD00002367
MOL File:
98-54-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-04 08:02:00
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4-tert-Butylphenol Properties

Melting point 96-101 °C (lit.)
Boiling point 236-238 °C (lit.)
Density 0.908 g/mL at 25 °C (lit.)
bulk density 450kg/m3
vapor pressure 1 mm Hg ( 70 °C)
refractive index 1.4787
FEMA 3918 | P-TERT-BUTYLPHENOL
FLAVIS Number 04.064 | 4-(1,1-Dimethylethyl)phenol
Flash point 113 °C
storage temp. Store below +30°C.
solubility ethanol: soluble50mg/mL, clear, colorless
form Flakes or Pastilles
pka 10.23(at 25℃)
color White to light beige
Specific Gravity 0.908
Odor at 1.00 % in propylene glycol. oakmoss leather
PH 7 (10g/l, H2O, 20℃)
explosive limit 0.8-5.3%(V)
Odor Type leathery
biological source synthetic
Water Solubility 8.7 g/L (20 ºC)
JECFA Number 733
Merck 14,1585
BRN 1817334
Henry's Law Constant 8.9×100 mol/(m3Pa) at 25℃, Parsons et al. (1972)
Stability Stable. Incompatible with copper, steel, bases, acid chlorides, acid anhydrides, oxidizing agents.
InChI 1S/C10H14O/c1-10(2,3)8-4-6-9(11)7-5-8/h4-7,11H,1-3H3
InChIKey QHPQWRBYOIRBIT-UHFFFAOYSA-N
SMILES CC(C)(C)c1ccc(O)cc1
LogP 3 at 23℃
Substances of Very High Concern (SVHC) Candidate List 4-tert-butylphenol (98-54-4)
CAS DataBase Reference 98-54-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 4-(1,1-DIMETHYLETHYL)PHENOL
FDA 21 CFR 175.300; 177.1580; 177.1585;177.2410
FDA UNII O81VMW36CV
NIST Chemistry Reference Phenol, p-tert-butyl-(98-54-4)
EPA Substance Registry System p-tert-Butylphenol (98-54-4)
UNSPSC Code 12352104
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H303+H313-H315-H318-H361-H335-H401-H412
Precautionary statements  P501-P261-P273-P202-P201-P271-P264-P280-P302+P352-P312-P362+P364-P332+P313-P304+P340+P312-P305+P351+P338+P310-P403+P233-P405
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,N
Risk Statements  37/38-41-51/53-62-38-37-34
Safety Statements  26-39-61-36/37/39-45
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  SJ8925000
Autoignition Temperature 475°C
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29071900
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Chronic 1
Eye Dam. 1
Repr. 2
Skin Irrit. 2
Hazardous Substances Data 98-54-4(Hazardous Substances Data)
Toxicity LD50 orally in rats: 3.25 ml/kg (Smyth)
REACH Registrations Active
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
3 0

4-tert-Butylphenol price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B99901 4-tert-Butylphenol 99% 98-54-4 1kg $130 2026-04-30 Buy
Sigma-Aldrich 506761 4-tert-Butylphenol PESTANAL?, analytical standard 98-54-4 1000mg $26.4 2024-03-01 Buy
Sigma-Aldrich 425761 4-tert-Butylphenol purified by sublimation, 99% 98-54-4 5g $40.8 2023-06-20 Buy
TCI Chemical B0230 4-tert-Butylphenol >98.0%(GC) 98-54-4 25g $17 2026-04-30 Buy
TCI Chemical B0230 4-tert-Butylphenol >98.0%(GC) 98-54-4 500g $24 2026-04-30 Buy
Product number Packaging Price Buy
B99901 1kg $130 Buy
506761 1000mg $26.4 Buy
425761 5g $40.8 Buy
B0230 25g $17 Buy
B0230 500g $24 Buy

4-tert-Butylphenol Chemical Properties,Uses,Production

Description

Para-tertiary-butylphenol formaldehyde resin (PTBPF- R) is a polycondensate of para-tertiary-butylphenol and formaldehyde. Major occupational sources are neoprene glues and adhesives in industry, in the shoemaking and leather industry or in car production. It is also used as a box preservative in box and furniture manufacture, and in the production of casting moulds, car-brake linings, insulated electrical cables, adhesives, printing inks and paper laminates. Para-tertiary-butyl-phenol is the sensitizer.

Chemical Properties

4-tert-Butylphenol is a white to pale yellow crystalline solid at room temperature and is sold in solid form as flakes or briquettes. 4-tert-butylphenol is employed in coating products, polymers, adhesives, sealants and for the synthesis of other substances.
The major use is as a monomer in chemical synthesis, e.g. for the production of polycarbonate, phenolic resins, epoxy resins. PtBP is used as a chain terminator in the synthesis of polycarbonate polymers. The main uses of polycarbonate are in compact discs, DVD and CD Rom manufacture.

Occurrence

Reported found in origanum (Coridothymus cap. (L.) Richb.)

Uses

Polycarbonate Chain Terminator, Glycidyl Ethers; Phosphate Esters, Fragrances, Oil Field Chemicals-Demulsifiers; Plasticizer for cellulose acetate; intermediate for antioxidants, special starches, oil-soluble phenolic resins; pour-point depressors and emulsion breakers for petroleum oils and some plastics; synthetic lubricants; insecticides; industrial odorants; motor-oil additives.

Uses

4-tert-Butylphenol is a phenol derivative. Its contact with skin may lead to leukoderma. It is widely used in the polymer industry. Reaction of 4-tert-Butylphenol with mushroom tyrosinase has been reported to afford 4-t-butyl-o-benzoquinone and kinetics of this enzymatic reaction has been investigated.

Uses

4-tert-butylphenol on condensation with formaldehyde gives calix[5]arene which is used in enzyme mimetics.

Application

4-tert-Butylphenol may be employed as carbon and energy supplement in the culture medium of Sphingobium fuliginis strains.
4-tert-Butylphenol is suitable reagent used in kinetic study of hydroxylation of 4-tert-butylphenol by mushroom tyrosinase. It may be used in the synthesis of calix[7]arene.

Preparation

Prepared by heating phenol with isobutanol in the presence of zinc chloride; also from phenol, tert- butyl chloride and excess alkali in alcohol

Definition

ChEBI: 4-tert-butylphenol is a member of the class of phenols that is phenol substituted with a tert-butyl group at position 4. It has a role as an allergen.

Synthesis Reference(s)

The Journal of Organic Chemistry, 22, p. 988, 1957 DOI: 10.1021/jo01359a609

General Description

Crystals or practically white flakes. Has a disinfectant-like odor. May float or sink in water. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Phenols, such as 4-tert-Butylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid.

Hazard

Irritant to eyes and skin.

Fire Hazard

Combustible.

Contact allergens

Para-tert-butylphenol is used with formaldehyde to produce the polycondensate p-tert-butylphenol-formaldehyde resins (PTBPFR). Major occupational sources are neoprene glues and adhesives in industry, in the shoemaking and leather industries or in car production. It is also used as a box preservative in box and furniture manufacture and in the production of casting molds, car brake linings, insulated electrical cables, adhesives, printing inks, and paper laminates. Para-tertbutylphenol seems to be the sensitizer

Safety Profile

Poison by intraperitoneal route. Moderately toxic by skin contact and ingestion. A skin and severe eye irritant. Questionable carcinogen with experimental neoplastigenic data. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid and irritating fumes. See also PHENOL and other butyl phenols.

Potential Exposure

Butylphenols may be used as intermediates in manufacturing varnish and lacquer resins; as a germicidal agent in detergent disinfectants; as a pour point depressant, in motor-oil additives; de-emulsifier for oil; soap-antioxidant, plasticizer, fumigant, and insecticide

Shipping

UN2430 Alkylphenols, solid, n.o.s. (including C2-C12 homologues), Hazard class: 8; Labels: 8— Corrosive material

Purification Methods

Crystallise the phenol to constant melting point from pet ether (b 60-80o). It sublimes in vacuo. Also purify it via the benzoate, as for phenol. The salicylate ester [87-18-30] has m 63-64o (from aqueous EtOH, or EtOH). [Beilstein 6 IV 3296.]

Incompatibilities

Vapors may form explosive mixture with air. These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may cause the gas to ignite and explode. Heat is also generated by the acid-base reaction with bases; such heating may initiate polymerization of the organic compound. React with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock

4-tert-Butylphenol Preparation Products And Raw materials

Raw materials

4-N-OCTYLPHENOL 2,6-DTBP Phenol AMBERLITE(R) IRC-50 Isobutylene
tert-Butanol Aluminum chloride p-Tert-butylphenol Polyisobutylene Benzoic acid
2,4,4-TRIMETHYL-2-PENTENE

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Preparation Products

2-[4-(TERT-BUTYL)PHENOXY]-5-NITROBENZALDEHYDE 4-tert-Butylphenyl Salicylate 6-TERT-BUTYL-4-METHYLCOUMARIN 2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL ALKYLPHENOL DISULFIDE
PHENOL-FORMALDEHYDE RESIN Rosin modified phenolic resin 4-tert-Butylcyclohexanol 2-Amino-4-tert-butylphenol 2-(5-TERT-BUTYL-2-HYDROXYPHENYL)BENZOTRIAZOLE
1-Tert-butyl-3-broMo-5-fluorobenzene 5-TERT-BUTYL-2-METHOXYBENZENEBORONIC ACID 4-TERT-BUTYLCYCLOHEXYLAMINE 2,2'-[cyclohexylidenebis[(2-methyl-4,1-phenylene)azo]]bis[4-tert-butylphenol] Chromate(3-), bis[3-[[5-(1,1-dimethylethyl)-2-(hydroxy-κO)phenyl]azo-κN1]-2-(hydroxy-κO)-5-nitrobenzenesulfonato(3-)]-, dipotassium hydrogen

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4-tert-Butylphenol Suppliers

Global( 491)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Jinyueyuan New Material Co. Ltd 18615187817; 18615187817 2793152786@qq.com China 394 58
Powerful Chemical (Shanghai) Co., Ltd. 021-62211590 18917958225; pwfchem@163.com China 75 58
Jinan Renyuan Chemical Co., Ltd. 0531-86128689 18396852370 2770911192@qq.com China 299 58
Shandong Yukang Chemical Co., Ltd 0531-15562663522 15562663522 sdykhg1@163.com China 438 58
Jinan Renyuan Chemical Co. Ltd 0531-86128689 13188898795 819291565@qq.com China 255 58
Nantong Subei Chemical Raw Materials Co., Ltd. 0513-85290972 18762756250 ntsbhg@163.com China 9277 58
Boxuan Chemical (Shandong) Co., Ltd. 17653188518 1280242276@qq.com China 999 58
shandongxinhenghuagongyouxiangongsi 15269160602 15269160602 15269160602@163.com China 1075 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Shandong Jinyueyuan New Material Co. Ltd 58
Powerful Chemical (Shanghai) Co., Ltd. 58
Jinan Renyuan Chemical Co., Ltd. 58
Shandong Yukang Chemical Co., Ltd 58
Jinan Renyuan Chemical Co. Ltd 58
Nantong Subei Chemical Raw Materials Co., Ltd. 58
Boxuan Chemical (Shandong) Co., Ltd. 58
shandongxinhenghuagongyouxiangongsi 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84

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View Lastest Price from 4-tert-Butylphenol manufacturers

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4-tert-Butylphenol pictures 2026-03-20 4-tert-Butylphenol
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 $100.00 1kg 99%min 200TON Hebei Chuanghai Biotechnology Co., Ltd
4-tert-Butylphenol pictures 2021-07-02 4-tert-Butylphenol
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 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-tert-Butylphenol pictures 2019-07-06 4-tert-Butylphenol
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 $8.00 1kg 99% 100MT Career Henan Chemical Co

4-tert-Butylphenol Spectrum

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Lowinox 070 Lowinox PTBT p-(tert-butyl)-pheno Phenol, 4-(1,1-dimethylethyl)- Phenol, 4-tert-butyl- p-terc.Butylfenol ucarbutylphenol4-t ucarbutylphenol4-tflake PARA TERTIARY BUTYL PHENO 4-tert-Butylphenol 97% 4-tert-Butylphenol, extra pure 4-tert-Butylphenol 5g [98-54-4] 4-tert-Butylphenol 3g [98-54-4] 4-tert-Butylphenol ,96% 4-tert-Butylphenol, 97% 1KG 4-tert-Butylphenol, 97% 2.5KG 4-tert-Butylphenol, 97% 5GR 4-tert-Butylphenol,97% The tertiary butyl phenol 4-tert.-Butylp 4-tert-Butylphenol purified by sublimation, 99% PARA-TERT-BUTYLPHENOL (PTBP) Para-tert-Butylphenol Polymer Grade 4-(1,1-DIMETHYL-1-ETHYL)PHENOL 4-(A A-DIMETHYLETHYL)PHENOL 4-TERTIARY BUTYL PHENOL 4-TERT-BUTYLPHENOL BUTYLPHEN FEMA 3918 1-Hydroxy-4-tert-butylbenzene 2-(p-Hydroxyphenyl)-2-methylprpane 4-(1,1-dimethylethyl)-pheno 4-Hydroxy-1-tert-butylbenzene 4-TERT-BUTYLPHENOL, ZONE REFINED (NUMBER OF PASSES:19) PARA-TERBUTYL PHENOL(PTBP) PARA-HYDROXYTERTBUTYLBENZENE BUTYLPHENOLPARATERTIARY PARA-TERT-BUTYLPHENOLRESIN PHENOL,PARA-(TERT-BUTYL)- Phenol,p-tert-butyl- 4-TERT-BUTYLPHENOL, SUBLIMED, 99% 4-TERT-BUTYLPHENOL, 1000MG, NEAT 4-TERT-BUTYLPHENOL 99+% para tertiaryButyl Phenol, Technical 4-Tert-ButylPhenolForSynthesis 4-TERT-BUTYLPHENOL, ZONE REFINED P-T-BUTYLPHENOL 4 - ter Butyl Phenol p-tert BUTYL PHENOL pure 4-tert-Butylphenol> 4-tert-ButylphenolZoneRefined(numberofpasses:19)> 4-tert-Butylphenol, puriss, 99%+ 4-tert-Butylphenol, puriss Phenyl Acetate Impurity 90 4-tert-Butylphenol 98% For Synthesis C10931600 4-tert-Butylphenol Adagrasib Impurity 43 4-tert-Butylphenol