1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester
- CAS No.
- 1087243-14-8
- Chemical Name:
- 1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester
- Synonyms
- GRL-0496;GRL-0496, 10 mM in DMSO;5-Chloro-3-pyridinyl 1H-indole-4-carboxylate;5-Chloropyridin-3-yl 1H-indole-4-carboxylate;1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester;chloropyridyl,GRL-0496,3CLpro,inhibit,GRL0496,Inhibitor,SARS-CoV,GRL 0496,SARS coronavirus
- CBNumber:
- CB19039741
- Molecular Formula:
- C14H9ClN2O2
- Molecular Weight:
- 272.69
- MDL Number:
- MFCD34471049
- MOL File:
- 1087243-14-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 483.9±35.0 °C(Predicted) |
|---|---|
| Density | 1.431±0.06 g/cm3(Predicted) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (>30 mg/mL) and ethanol (>25 mg/mL) |
| form | solid |
| pka | 15.35±0.30(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | BOSZJNSICHFHMA-UHFFFAOYSA-N |
| SMILES | ClC1=CN=CC(OC(C2=CC=CC3=C2C=CN3)=O)=C1 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3251 | GRL-1720 ≥98% (HPLC) | 1087243-14-8 | 5MG | $76.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3251 | GRL-1720 ≥98% (HPLC) | 1087243-14-8 | 25MG | $310 | 2026-04-30 | Buy |
| Cayman Chemical | 36114 | GRL-0496 ≥98% | 1087243-14-8 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 36114 | GRL-0496 ≥98% | 1087243-14-8 | 5mg | $148 | 2026-04-30 | Buy |
| Cayman Chemical | 36114 | GRL-0496 ≥98% | 1087243-14-8 | 10mg | $279 | 2026-04-30 | Buy |
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester Chemical Properties,Uses,Production
Description
GRL-0496 (1087243-14-8) is a potent (IC50= 30 nM in cell culture assays) inhibitor of severe acute respiratory syndrome-coronavirus chymotrypsin-like protease (SARS-CoV 3CLpro).1
Uses
GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].
Definition
ChEBI: (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate is an indolyl carboxylic acid. It has a role as an anticoronaviral agent.
References
[1] ARUN K. GHOSH . Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 20: Pages 5684-5688. DOI:10.1016/j.bmcl.2008.08.082
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5987 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| Z-trans Biochemistry Technology (Suzhou) Co.,Ltd | 0512-66317708 13372112871 | huijuan@zitrans.cn | China | 2260 | 58 |
