dichlorisone
- CAS No.
- 7008-26-6
- Chemical Name:
- dichlorisone
- Synonyms
- Disoderm;Diloderm;9,11β-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;(11β)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 9,11-dichloro-17,21-dihydroxy-, (11β)-;(8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- CBNumber:
- CB1932243
- Molecular Formula:
- C21H26Cl2O4
- Molecular Weight:
- 413.34
- MDL Number:
- MFCD00232919
- MOL File:
- 7008-26-6.mol
- MSDS File:
- SDS
| Melting point | 238-241 °C (decomp)(Solv: acetone (67-64-1)) |
|---|---|
| alpha | D20 +134° (pyridine) |
| Boiling point | 586.4±50.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| solubility | Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Pyridine (Slightly, Sonicated) |
| form | Solid |
| pka | 11.99±0.70(Predicted) |
| color | White to Off-White |
| FDA UNII | AMW2MRV3OT |
dichlorisone price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | HAA00826 | Dichlorisone | 7008-26-6 | 100mg | $995 | 2026-06-04 | Buy |
| Biosynth | HAA00826 | Dichlorisone | 7008-26-6 | 250mg | $1620 | 2026-06-04 | Buy |
| aablocks | AA00FDIB | Dichlorisone | 7008-26-6 | 25mg | $320 | 2026-05-28 | Buy |
| aablocks | AA00FDIB | Dichlorisone | 7008-26-6 | 250mg | $1624 | 2026-05-28 | Buy |
| TRC | D431755 | Dichlorisone | 7008-26-6 | 25mg | $180 | 2021-12-16 | Buy |
dichlorisone Chemical Properties,Uses,Production
Originator
Diloderm ,Schering,US,1960
Uses
Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.
Manufacturing Process
A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21-
acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous
hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture
is stirred for 2 hours and poured into ice water. The crude product is filtered
and washed with water to give 1.12 g of solid material, which is recrystallized
from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4-
pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).
Therapeutic Function
Antipruritic, Antihistaminic, Appetite stimulant
dichlorisone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 17392216152 | 1035@dideu.com | China | 9991 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39319 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 17717235263 | offer.de@lgcgroup.com | China | 38135 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
