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1-Bromo-2-difluoromethoxy-4-fluoro-benzene

1-Bromo-2-difluoromethoxy-4-fluoro-benzene Structure
1-Bromo-2-difluoromethoxy-4-fluoro-benzene structure
CAS No.
954235-83-7
Chemical Name:
1-Bromo-2-difluoromethoxy-4-fluoro-benzene
Synonyms
2-Bromo-alpha,alpha,5-trifluoroanisole;2-(Difluoromethoxy)-4-fluorobromobenzene;1-Bromo-2-difluoromethoxy-4-fluoro-benzene;2-(Difluoromethoxy)-4-fluorobromobenzene 98%;Benzene, 1-bromo-2-(difluoromethoxy)-4-fluoro-
CBNumber:
CB21113057
Molecular Formula:
C7H4BrF3O
Molecular Weight:
241.01
MDL Number:
MFCD11036070
MOL File:
954235-83-7.mol
MSDS File:
SDS
Last updated:2026-05-27 23:53:32
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1-Bromo-2-difluoromethoxy-4-fluoro-benzene Properties

Boiling point 185.4±35.0 °C(Predicted)
Density 1.660±0.06 g/cm3(Predicted)
storage temp. 2-8°C
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H227-H302-H319-H412
Precautionary statements  P210-P273-P305+P351+P338
HS Code  2909309090

1-Bromo-2-difluoromethoxy-4-fluoro-benzene price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC48301 2-(Difluoromethoxy)-4-fluorobromobenzene >98% 954235-83-7 1g $21 2026-06-04 Buy
Apolloscientific PC48301 2-(Difluoromethoxy)-4-fluorobromobenzene >98% 954235-83-7 5g $62 2026-06-04 Buy
Apolloscientific PC48301 2-(Difluoromethoxy)-4-fluorobromobenzene >98% 954235-83-7 25g $244 2026-06-04 Buy
Apolloscientific PC48301 2-(Difluoromethoxy)-4-fluorobromobenzene >98% 954235-83-7 100g $906 2026-06-04 Buy
Activate Scientific AS49466 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene 98% 954235-83-7 1g $49 2026-06-04 Buy
Product number Packaging Price Buy
PC48301 1g $21 Buy
PC48301 5g $62 Buy
PC48301 25g $244 Buy
PC48301 100g $906 Buy
AS49466 1g $49 Buy

1-Bromo-2-difluoromethoxy-4-fluoro-benzene Chemical Properties, Uses, Production

Synthesis

Sodium chlorodifluoroacetate

1895-39-2

2-Bromo-5-fluorophenol

147460-41-1

1-Bromo-2-difluoromethoxy-4-fluoro-benzene

954235-83-7

General procedure for the synthesis of 1-bromo-2-(difluoromethoxy)-4-fluorobenzene from sodium difluorochloroacetate and 2-bromo-5-fluorophenol: 1. to a solution of 2-bromo-5-fluorophenol (3 g, 15.7 mmol) in DMF (5 ml) was added cesium carbonate (7.7 g, 23.56 mmol, 1.5 eq.) and sodium difluorochloroacetate (6 g, 39.26 mmol, 2.5 eq.). 2. The reaction mixture was heated and stirred at 100 °C for 15 hours. 3. After completion of the reaction, the reaction was terminated with water and ethyl acetate (3 x 50 ml). 4. The organic layer was separated, washed with water and brine, and then dried over anhydrous sodium sulfate. 5. The solvent was removed by pressurized distillation to obtain the crude product. 6. The crude product was purified by column chromatography (silica gel 60-120, eluent: 10% hexane solution of ethyl acetate) in 58% (2.2 g) yield.

References

[1] Patent: WO2014/162039, 2014, A1. Location in patent: Page/Page column 41
[2] Patent: EP2394987, 2011, A1. Location in patent: Page/Page column 9
[3] Patent: WO2012/143329, 2012, A1. Location in patent: Page/Page column 121

1-Bromo-2-difluoromethoxy-4-fluoro-benzene Preparation Products And Raw materials

Raw materials

Sodium chlorodifluoroacetate 2-Bromo-5-fluorophenol N,N-Dimethylformamide Cesium carbonate

Preparation Products

1-Bromo-2-difluoromethoxy-4-fluoro-benzene Suppliers

Global Suppliers ( 61)
Supplier Tel Email Country ProdList Advantage
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Changzhou Anxuan Chemical, Co., Ltd. 13912302692 sales@anxuanchem.com China 4824 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Hangzhou Molcore Biopharmatech Co.,Ltd 400-711-5280 86-571-81025280 sales@molcore.com China 9957 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Allfluoro Pharmaceutical Company Limited +86-400-0216110 +86-15958047586 sales@allfluoro.com China 11380 58
Supplier Advantage
Nanjing Norris-Pharm Technology Co., Ltd 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
Cool Pharm, Ltd 58
Changzhou Anxuan Chemical, Co., Ltd. 58
Amadis Chemical Company Limited 58
Hangzhou Molcore Biopharmatech Co.,Ltd 58
Aikon International Limited 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Allfluoro Pharmaceutical Company Limited 58

View Latest Price from 1-Bromo-2-difluoromethoxy-4-fluoro-benzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Bromo-2-difluoromethoxy-4-fluoro-benzene pictures 2026-02-02 1-Bromo-2-difluoromethoxy-4-fluoro-benzene
954235-83-7
 10mg 99%HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd

1-Bromo-2-difluoromethoxy-4-fluoro-benzene Spectrum

1-Bromo-2-difluoromethoxy-4-fluoro-benzene(954235-83-7)1HNMR

954235-83-7 (1-Bromo-2-difluoromethoxy-4-fluoro-benzene) Related Search:

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1-Bromo-2-difluoromethoxy-4-fluoro-benzene 2-(Difluoromethoxy)-4-fluorobromobenzene 2-Bromo-alpha,alpha,5-trifluoroanisole 2-(Difluoromethoxy)-4-fluorobromobenzene 98% Benzene, 1-bromo-2-(difluoromethoxy)-4-fluoro- 954235-83-7