Fantofarone
- CAS No.
- 114432-13-2
- Chemical Name:
- Fantofarone
- Synonyms
- CS-2766;SR-33557;Fantofarone;Fantofarone, 10 mM in DMSO;FANTOFARONE;SR-33557;SR33557; 114432-13-2;Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels;2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine;2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[2-(propan-2-yl)indolizin-1-yl]sulfonyl}phenoxy)propyl]amine;3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine;Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-
- CBNumber:
- CB21118032
- Molecular Formula:
- C31H38N2O5S
- Molecular Weight:
- 550.71
- MDL Number:
- MFCD00867144
- MOL File:
- 114432-13-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 82-83° |
|---|---|
| Density | dz 1.21 g/cm3 |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml |
| form | A crystalline solid |
| pka | 8.34 ± 0.05(at 25℃) |
| color | Light yellow to yellow |
| InChIKey | ITAMRBIZWGDOHW-UHFFFAOYSA-N |
| SMILES | C1(CCN(C)CCCOC2=CC=C(S(C3=C4N(C=CC=C4)C=C3C(C)C)(=O)=O)C=C2)=CC=C(OC)C(OC)=C1 |
| FDA UNII | KU213XYO69 |
Fantofarone price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26381 | Fantofarone ≥98% | 114432-13-2 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 26381 | Fantofarone ≥98% | 114432-13-2 | 5mg | $202 | 2026-04-30 | Buy |
| Cayman Chemical | 26381 | Fantofarone ≥98% | 114432-13-2 | 10mg | $354 | 2026-04-30 | Buy |
| Cayman Chemical | 26381 | Fantofarone ≥98% | 114432-13-2 | 25mg | $820 | 2026-04-30 | Buy |
| ChemScene | CS-0025047 | Fantofarone 99.91% | 114432-13-2 | 5mg | $97 | 2026-06-04 | Buy |
Fantofarone Chemical Properties, Uses, Production
Uses
Fantofarone is a highly potent Calcium Channel antagonist.
Biological Activity
Fantofarone is a potent antagonist of Calcium Channels.
in vitro
It can be seen that the calcium channel blockers VIZ and Fantofarone (SR) possess a weak intrinsic antimalarial property compared to CQ, and both appear slightly more potent on the CQ-resistant than on the CQ-sensitive parasites.
in vivo
Treatment with isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.), a reduction is observed in the occurrence and severity of vasospasm, whereas verapamil (0.2 mg/kg, i.v.) is much less effective.
References
[1] Adovelande J, et al. Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochem Pharmacol. 1998 Feb 15;55(4):433-40. DOI:10.1016/s0006-2952(97)00482-6
[2] Dongay B, et al. Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model. Biochem Pharmacol. 1998 Jun 15;55(12):2047-50. DOI:10.1016/s0006-2952(98)00026-4
Fantofarone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1161 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1782 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
View Latest Price from Fantofarone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Fantofarone
114432-13-2
|
$72.00-247.00 | 99.19% | 10g | TargetMol Chemicals Inc. |
-
- Fantofarone
114432-13-2
- $72.00-247.00
- 99.19%
- TargetMol Chemicals Inc.
