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5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester Structure
5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester structure
CAS No.
51985-95-6
Chemical Name:
5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester
Synonyms
Methyl 5-hydroxy-1-Methyl-1H-pyrazole-3-carboxylate;NSC 338308;Methyl 5-hydroxy-1-methyl-3-pyrazolecarboxylate;methyl 2-methyl-3-oxo-1H-pyrazole-5-carboxylate;methyl 5-hydroxy-1-methyl-pyrazole-3-carboxylate;1H-Pyrazole-3-carboxylic acid, 1-methyl-, methyl ester;Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate 97%;Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate;Methyl 1-Methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate;5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
CBNumber:
CB21119246
Molecular Formula:
C6H8N2O3
Molecular Weight:
156.14
MDL Number:
MFCD01851055
MOL File:
51985-95-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:50:10
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5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester Properties

Melting point 195-200°C
Boiling point 330.7±22.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form solid
pka 8.26±0.28(Predicted)
color Pale brown
InChI InChI=1S/C6H8N2O3/c1-8-5(9)3-4(7-8)6(10)11-2/h3,9H,1-2H3
InChIKey IWOKRTHKTAEDLP-UHFFFAOYSA-N
SMILES N1(C)C(O)=CC(C(OC)=O)=N1
UNSPSC Code 12352200
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280
WGK Germany  3
HazardClass  IRRITANT
HS Code  2933199090
Storage Class 13 - Non Combustible Solids

5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 754609 Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate 97% 51985-95-6 1g $135 2023-06-20 Buy
AstaTech 56700 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER 97% 51985-95-6 1G $45 2026-04-30 Buy
AstaTech 56700 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER 97% 51985-95-6 5G $135 2026-04-30 Buy
AstaTech 56700 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER 97% 51985-95-6 25G $472 2026-04-30 Buy
Apolloscientific OR346186 5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester 97% 51985-95-6 5g $104 2026-06-04 Buy
Product number Packaging Price Buy
754609 1g $135 Buy
56700 1G $45 Buy
56700 5G $135 Buy
56700 25G $472 Buy
OR346186 5g $104 Buy

5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester Chemical Properties, Uses, Production

Synthesis

2-Butenedioic acid, 2-(1-methylhydrazinyl)-, 1,4-dimethyl ester, (2E)-

58364-79-7

5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

51985-95-6

b) Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (12.2 g, 65 mmol) was dissolved in xylene (65 mL) and p-toluenesulfonic acid (0.9 g, 4.7 mmol) was added. The reaction mixture was heated to reflux for 6 hours. Upon completion of the reaction, it was cooled to room temperature and stirred overnight. The precipitated solid was collected by filtration and dissolved in ethyl acetate. The organic phase was washed sequentially with sodium bicarbonate solution and saturated brine and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give methyl 1-methyl-5-hydroxypyrazole-3-carboxylate (7.49 g, 74% yield) as a light brown solid. The purity of the product was improved by diisopropyl ether milling. Mass spectrometry analysis showed: m/e = 157.2 [M + H]+.

References

[1] Patent: WO2010/127975, 2010, A1. Location in patent: Page/Page column 131

5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

2-Butenedioic acid, 2-(1-methylhydrazinyl)-, 1,4-dimethyl ester, (2E)- Ethyl acetate p-Toluenesulfonic acid monohydrate Sodium bicarbonate Xylene

Preparation Products

1H-Pyrazole-3-carboxylicacid,5-(carboxymethoxy)-1-methyl-(9CI) methyl 5-methoxy-1-methyl-1H-pyrazole-3-carboxylate

5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester Suppliers

Global Suppliers ( 111)
Supplier Tel Email Country ProdList Advantage
Nanjing Chemcn Pharmaceutical Co., Ltd. 18114022054; 18114022054 3317707757@qq.com China 301 55
Ningbo Zeyu Chemical Technology Co., Ltd 15066123231 2278736577@qq.com China 494 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Wuhan Luohua Medical Technology Co.,Ltd. 13477084141; 13477084141 sales@luohuapharm.com China 468 60
China Langchem Inc. 0086-21-58956006 China 7798 57
Acorn PharmaTech Co., Ltd. 025-58395930 sales@acornpharma.com China 982 60
Supplier Advantage
Nanjing Chemcn Pharmaceutical Co., Ltd. 55
Ningbo Zeyu Chemical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
Wuhan Luohua Medical Technology Co.,Ltd. 60
China Langchem Inc. 57
Acorn PharmaTech Co., Ltd. 60

View Latest Price from 5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate pictures 2022-04-22 methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate
51985-95-6
 98%min 100kgs/month Shanghai Rlavie Technology Co ltd
5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER pictures 2020-01-13 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
51985-95-6
 $1.00 1KG 99% 100KG Career Henan Chemical Co

5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester Spectrum

5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER (51985-95-6)1HNMR

51985-95-6 (5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester) Related Search:

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1-Methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid methyl ester Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate 97% Methyl 5-hydroxy-1-methyl-3-pyrazolecarboxylate NSC 338308 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER 1H-Pyrazole-3-carboxylic acid, 1-methyl-, methyl ester Methyl 1-Methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate 1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-methyl-, methyl ester 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH methyl 5-hydroxy-1-methyl-pyrazole-3-carboxylate methyl 2-methyl-3-oxo-1H-pyrazole-5-carboxylate Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate Methyl 5-hydroxy-1-Methyl-1H-pyrazole-3-carboxylate 51985-95-6