Boc-L-beta-homoglutamic acid 6-benzyl ester
- CAS No.
- 218943-30-7
- Chemical Name:
- Boc-L-beta-homoglutamic acid 6-benzyl ester
- Synonyms
- Boc-β-homoglutamic;Boc--HoGlu(OBzl)-OH;Boc-b-HoGlu(OBzl)-OH;Boc-2-HoGlu(OBzl)-OH;Boc-β-HoGlu(OBzl)-OH;Boc-β-HomoGlu(Obzl)-OH;Boc-p-HomoGlu(OBzl)-OH;Boc-beta-HGlu(OBzl)-OH;BOC-GLU(OBZL)-(C*CH2)OH;BOC-BETA-HOGLU(OBZL)-OH
- CBNumber:
- CB2113032
- Molecular Formula:
- C18H25NO6
- Molecular Weight:
- 351.39
- MDL Number:
- MFCD01862936
- MOL File:
- 218943-30-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 530.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 4.35±0.10(Predicted) |
| CAS DataBase Reference | 218943-30-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P302+P352-P304+P340-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
Boc-L-beta-homoglutamic acid 6-benzyl ester price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265299 | Boc-L-beta-homoglutamic acid 6-benzyl ester Asreported | 218943-30-7 | 100mg | $363 | 2026-06-03 | Buy |
| Usbiological | 265299 | Boc-L-beta-homoglutamic acid 6-benzyl ester Asreported | 218943-30-7 | 250mg | $463 | 2026-06-03 | Buy |
| Usbiological | 265299 | Boc-L-beta-homoglutamic acid 6-benzyl ester Asreported | 218943-30-7 | 500mg | $623 | 2026-06-03 | Buy |
| Usbiological | 265299 | Boc-L-beta-homoglutamic acid 6-benzyl ester Asreported | 218943-30-7 | 1g | $1065 | 2026-06-03 | Buy |
| Usbiological | 265299 | Boc-L-beta-homoglutamic acid 6-benzyl ester Asreported | 218943-30-7 | 2g | $1500 | 2026-06-03 | Buy |
Boc-L-beta-homoglutamic acid 6-benzyl ester Chemical Properties, Uses, Production
Chemical Properties
White powder
Uses
Starting materials for peptide synthesis, peptidomimetic and medicinal chemistry, protected amino acids, coupling reagents, linkers and resins, natural and unusual amino acids and building blocks used in peptide synthesis, peptidomimetic and medicinal chemistry. Reagents for PEGylation, Life science Research and biocatalysis.
Uses
Boc-l-beta-homoglutamic acid 6-benzyl ester
Synthesis
![Hexanoic acid, 6-diazo-4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-oxo-, phenylmethyl ester, (4S)-](/CAS/20240320/GIF/128135-31-9.gif)
128135-31-9
218943-30-7
The general procedure for the synthesis of (S)-6-(benzyloxy)-3-((tert-butoxycarbonyl)amino)-6-oxohexanoic acid from 6-benzyl 3-(tert-butoxycarbonyl)amino)adipate (6) was as follows: diazoxide (5) (3.00 g, 8.30 mmol) was dissolved in a 5:1 solvent mix of THF/H2O (60 ml), cooled in an ice bath, and aluminum foil was used to wrap the flask to avoid light. Subsequently, silver trifluoroacetate (0.37 g, 1.66 mmol) was added and NMM (2.28 ml, 20.75 mmol) was added dropwise. The reaction mixture was reacted under stirring for 4.5 hours and gradually warmed up to room temperature. After completion of the reaction, THF was removed by evaporation, 1N KHSO4 aqueous solution (40 ml) was added and the precipitate was removed by filtration. The aqueous phase was extracted with ethyl acetate and the organic phase was washed twice with 1N KHSO4 aqueous solution, dried over MgSO4 and then evaporated in vacuum to remove the solvent. The yellow crude product obtained was ground with ether to give the target compound as a white solid (2.17 g, 74% yield).1H NMR (CDCl3, 300 MHz) δ: 7.42-7.31 (m, 5H), 5.13 (s, 2H), 4.00 (m, 1H), 4.03-3.90 (m, 1H), 2.70-2.56 (m, 2H) , 2.54-2.40 (m, 2H), 1.98-1.85 (m, 2H), 1.45 (s, 9H).
References
[1] Patent: WO2017/37142, 2017, A1. Location in patent: Paragraph 00318; 00319
[2] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 20, p. 3331 - 3340
[3] Organic Letters, 2000, vol. 2, # 13, p. 1943 - 1946
[4] RSC Advances, 2014, vol. 4, # 70, p. 37419 - 37422
Boc-L-beta-homoglutamic acid 6-benzyl ester Preparation Products And Raw materials
Boc-L-beta-homoglutamic acid 6-benzyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Shanghai HC Biotech Co., Ltd | 021-20227858 | sale@hcbiotech.com.cn | China | 1173 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| ChemPep, Inc. | +1 (888) 615-9178 / (561) 791-8787 | service@chempep.com | United States | 2138 | 57 |
218943-30-7 (Boc-L-beta-homoglutamic acid 6-benzyl ester) Related Search:
1of4
