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N-Boc-endo-3-aminotropane

N-Boc-endo-3-aminotropane structure

CAS No.: 207405-68-3

Chemical Name:: N-Boc-endo-3-aminotropane

Synonyms: N-Boc-endo-3-aminotropane;endo-3-Amino-8-Boc-8-azab...;N-Boc-3-amino-8-azabicyclo[3.2.1]octane;endo-3-Amino-8-Boc-8-azabicyclo[3.2.1]octane;tert-Butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-butyl (1S,5R)-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate;(1S,3r,5R)tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-butyl (1R,3r,5S)-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate;1,1-DiMethylethyl 3-endo-aMino-8-azabicyclo[3.2.1]octane-8-carboxylate;(1R,3s,5S)-rel-tert-Butyl 3-aMino-8-azabicyclo[3.2.1]octane-8-carboxylate

CBNumber:: CB21235203

Molecular Formula:: C12H22N2O2

Molecular Weight:: 226.32

MDL Number:: MFCD18428077

MOL File:: 207405-68-3.mol

MSDS File:: SDS

Last updated:2026-05-27 23:54:35

Product description	Number	Pack Size	Price
N-Boc-endo-3-aminotropane	458354	50mg	$319
N-Boc-endo-3-aminotropane	458354	250mg	$425
N-Boc-endo-3-aminotropane	FB71481	0.5g	$150
N-Boc-endo-3-aminotropane	FB71481	1g	$192.18
N-Boc-endo-3-aminotropane	FB71481	2g	$288.26
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N-Boc-endo-3-aminotropane Properties

Boiling point	313.2±35.0 °C(Predicted)
Density	1.084
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	10.12±0.20(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1/C12H22N2O2/c1-12(2,3)16-11(15)14-9-4-5-10(14)7-8(13)6-9/h8-10H,4-7,13H2,1-3H3/t9-,10-/s3
InChIKey	NZJKEPNCNBWESN-DPIMBTEZNA-N
SMILES	C(=O)(OC(C)(C)C)N1[C@H]2CC[C@H]1C[C@H](N)C2 \|&1:8,11,13,r\|
CAS DataBase Reference	207405-68-3

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS05
Signal word	Danger
Hazard statements	H315-H302-H335-H318
Precautionary statements	P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310
HS Code	2924297099

N-Boc-endo-3-aminotropane price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	458354	N-Boc-endo-3-aminotropane	207405-68-3	50mg	$319	2026-06-03	Buy
Usbiological	458354	N-Boc-endo-3-aminotropane	207405-68-3	250mg	$425	2026-06-03	Buy
Biosynth	FB71481	N-Boc-endo-3-aminotropane	207405-68-3	0.5g	$150	2026-06-04	Buy
Biosynth	FB71481	N-Boc-endo-3-aminotropane	207405-68-3	1g	$192.18	2026-06-04	Buy
Biosynth	FB71481	N-Boc-endo-3-aminotropane	207405-68-3	2g	$288.26	2026-06-04	Buy

Product number	Packaging	Price	Buy
458354	50mg	$319	Buy
458354	250mg	$425	Buy
FB71481	0.5g	$150	Buy
FB71481	1g	$192.18	Buy
FB71481	2g	$288.26	Buy

N-Boc-endo-3-aminotropane Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

N-Boc-endo-3-aminotropane is used as a reagent in the synthesis of tropane-derived CCR5 receptor antagonists.

Synthesis

8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-[(phenylmethyl)amino]-, 1,1-dimethylethyl ester, (3-endo)-

207405-67-2

207405-68-3

TERT-BUTYL (1R,3R,5S)-3-(BENZYLAMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE (Compound 3b, 7.0 g, 22.2 mmol) was used as a raw material, which was mixed with ammonium formate (7.0 g, 111 mmol) and 20% palladium hydroxide /carbon catalyst (0.7 g) in ethanol (200 ml). The reaction mixture was stirred at 50°C for 2 hours. After completion of the reaction, it was cooled to room temperature and the catalyst was removed by filtration. The filtrate was concentrated by rotary evaporation and purified by column chromatography to afford the target product tert-butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate (Compound 3c, 4.7 g, 94% yield).

References

[1] Patent: US2017/44187, 2017, A1. Location in patent: Paragraph 0183; 0185
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 20, p. 6538 - 6546
[3] Patent: EP937069, 2006, B1. Location in patent: Page/Page column 74
[4] Patent: US2005/131011, 2005, A1. Location in patent: Page/Page column 18
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 11, p. 3756 - 3767

N-Boc-endo-3-aminotropane Preparation Products And Raw materials

Raw materials

N-Boc-Nortropinone 8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-[(phenylmethyl)amino]-, 1,1-dimethylethyl ester, (3-endo)- Ethanol Ammonium formate

Preparation Products

N-Boc-exo-3-aminotropane

N-Boc-endo-3-aminotropane Suppliers

Global( 105)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21135	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2028	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +86-18949823763	sales@tnjchem.com	China	25333	58
Protheragen-ING	+86-15618352007	info@protheragen-ing.com	United States	3867	58
Sichuan Biosynce Pharmatech Co., Ltd.		diane@biosynce.com	China	4863	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Protheragen-ING	58
Sichuan Biosynce Pharmatech Co., Ltd.	58

View Lastest Price from N-Boc-endo-3-aminotropane manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-10	N-Boc-endo-3-aminotropane 207405-68-3	$1.00	1KG	99%	200kg	Career Henan Chemical Co

N-Boc-endo-3-aminotropane
207405-68-3
$1.00
99%
Career Henan Chemical Co

N-Boc-endo-3-aminotropane Spectrum

N-Boc-endo-3-aminotropane(207405-68-3)¹HNMR

207405-68-3(N-Boc-endo-3-aminotropane)Related Search:

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endo-3-Amino-8-Boc-8-azabicyclo[3.2.1]octane endo-3-Amino-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester N-Boc-3-amino-8-azabicyclo[3.2.1]octane endo-3-Amino-8-Boc-8-azab... 1,1-DiMethylethyl 3-endo-aMino-8-azabicyclo[3.2.1]octane-8-carboxylate (1R,3s,5S)-rel-tert-Butyl 3-aMino-8-azabicyclo[3.2.1]octane-8-carboxylate tert-butyl (1S,5R)-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate tert-Butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate N-Boc-endo-3-aminotropane (3-endo)-3-Amino-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester tert-butyl (1R,3r,5S)-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate Racemic-(1R,3R,5S)-Tert-Butyl 3-Amino-8-Azabicyclo[3.2.1]Octane-8-Carboxylate 8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3-endo)- (1S,3r,5R)tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate 207405-68-3 Building Blocks/Intermediates