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ChemicalBook >> CAS DataBase List >>2,4-Dichloro-3-iodopyridine

2,4-Dichloro-3-iodopyridine

2,4-Dichloro-3-iodopyridine Structure
2,4-Dichloro-3-iodopyridine structure
CAS No.
343781-36-2
Chemical Name:
2,4-Dichloro-3-iodopyridine
Synonyms
Pyridine, 2,4-dichloro-3-iodo-
CBNumber:
CB21471058
Molecular Formula:
C5H2Cl2IN
Molecular Weight:
273.89
MDL Number:
MFCD09033756
MOL File:
343781-36-2.mol
MSDS File:
SDS
Last updated:2026-06-04 16:00:12
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2,4-Dichloro-3-iodopyridine Properties

Melting point 90-94 °C
Boiling point 290.3±35.0 °C(Predicted)
Density 2.129±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
form solid
pka -1.17±0.10(Predicted)
Appearance Off-white to light yellow Solid
InChI 1S/C5H2Cl2IN/c6-3-1-2-9-5(7)4(3)8/h1-2H
InChIKey OKXJLNYZTJLVJZ-UHFFFAOYSA-N
SMILES Clc1ccnc(Cl)c1I
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P301+P312+P330-P305+P351+P338+P310
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26-39
RIDADR  UN 2811
WGK Germany  3
HazardClass  IRRITANT
HS Code  2933399990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

2,4-Dichloro-3-iodopyridine price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 721069 2,4-Dichloro-3-iodopyridine 97% 343781-36-2 1g $52 2023-01-07 Buy
Apolloscientific OR345324 2,4-Dichloro-3-iodopyridine 99% 343781-36-2 5g $24 2026-06-04 Buy
Apolloscientific OR345324 2,4-Dichloro-3-iodopyridine 99% 343781-36-2 25g $79 2026-06-04 Buy
Activate Scientific AS29614 2,4-Dichloro-3-iodopyridine 97% 343781-36-2 1g $24 2026-06-04 Buy
Apolloscientific OR345324 2,4-Dichloro-3-iodopyridine 99% 343781-36-2 100g $275 2026-06-04 Buy
Product number Packaging Price Buy
721069 1g $52 Buy
OR345324 5g $24 Buy
OR345324 25g $79 Buy
AS29614 1g $24 Buy
OR345324 100g $275 Buy

2,4-Dichloro-3-iodopyridine Chemical Properties,Uses,Production

Uses

2,4-Dichloro-3-iodopyridine can be used as a pharmaceutical synthesis intermediate. It is prepared by reacting 2,4-dichloropyridine with n-butyllithium and iodine, and can be used to prepare another intermediate, 2,4-dichloro-3-trifluoromethylpyridine. It can also be obtained by iodination of 2,4-dichloropyridine or by chlorination of 2,4-dihydroxy-3-iodopyridine with phosphorus oxychloride.

Synthesis

2,4-Dichloropyridine

26452-80-2

2,4-Dichloro-3-iodopyridine

343781-36-2

General procedure for the synthesis of 2,4-dichloro-3-iodopyridine from 2,4-dichloropyridine: To a solution of anhydrous tetrahydrofuran (THF, 40 mL) of 2,4-dichloropyridine (5.2 g, 35.137 mmol) and N,N-diisopropylethylamine (DIPEA, 3.911 g, 38.651 mmol), the solution was cooled to -50 °C under nitrogen protection. At -78 °C, n-butyllithium (n-BuLi, 24.157 mL, 38.651 mmol, 1.6 M in hexane solution) was added dropwise. The reaction mixture was stirred at -78 °C for 45 min. Subsequently, a solution of iodine (9.81 g, 38.651 mmol) in anhydrous THF (20 mL) was added dropwise. The mixture was continued to be stirred at -78 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature, diluted with ethyl acetate (EtOAc) and the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) and saturated aqueous sodium thiosulfate (Na2S2O3). The organic layer was separated, the organic extracts were combined, washed with saturated aqueous sodium bicarbonate (NaHCO3), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel as stationary phase, heptane/dichloromethane gradient elution, dichloromethane up to 20%). The fraction containing the target product was collected and concentrated under reduced pressure to afford the intermediate compound 2,4-dichloro-3-iodopyridine (D5, 7.8 g, 81% yield).

References

[1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[2] Patent: WO2010/130422, 2010, A1. Location in patent: Page/Page column 53
[3] Patent: WO2010/130423, 2010, A1. Location in patent: Page/Page column 53
[4] Patent: WO2010/130424, 2010, A1. Location in patent: Page/Page column 104-105
[5] Patent: WO2012/62752, 2012, A1. Location in patent: Page/Page column 26

2,4-Dichloro-3-iodopyridine Preparation Products And Raw materials

Raw materials

2,4-Dichloropyridine iodine Tetrahydrofuran N,N-Diisopropylethylamine Hexane
n-Butyllithium

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Preparation Products

2,4-Dichloropyridine-3-carboxylic acid

2,4-Dichloro-3-iodopyridine Suppliers

Global( 125)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Boc Chemical Co.,Ltd 021-34975603-808 18721111801 sales@bocpharma.com China 991 64
Nanjing Lynsci Chemical Co., Ltd +86-025-83208253 +86-13851694729 layefe@163.com China 234 62
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Shanghai Yolne Chemical Co., Ltd. 021-62960152 934678158@qq.com China 9886 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
ChemFuture PharmaTech (Jiangsu) Ltd 65
Energy Chemical 61
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
Shanghai Boc Chemical Co.,Ltd 64
Nanjing Lynsci Chemical Co., Ltd 62
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai Yolne Chemical Co., Ltd. 55

View Lastest Price from 2,4-Dichloro-3-iodopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Dichloro-3-iodopyridine pictures 2026-05-15 2,4-Dichloro-3-iodopyridine
343781-36-2
 $1.50 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
2,4-Dichloro-3-iodopyridine pictures 2024-03-28 2,4-Dichloro-3-iodopyridine
343781-36-2
 25kg 98% PNP Biotech Co. Ltd
2,4-Dichloro-3-iodopyridine pictures 2019-07-06 2,4-Dichloro-3-iodopyridine
343781-36-2
 $1.00 1kg 98% 200KG Career Henan Chemical Co

2,4-Dichloro-3-iodopyridine Spectrum

2,4-Dichloro-3-iodopyridine(343781-36-2)1HNMR

343781-36-2(2,4-Dichloro-3-iodopyridine)Related Search:

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Pyridine, 2,4-dichloro-3-iodo- 343781-36-2 Heterocycle-Pyridine series