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ChemicalBook >> CAS DataBase List >>2,4-Dichloro-3-iodopyridine

2,4-Dichloro-3-iodopyridine

2,4-Dichloro-3-iodopyridine Structure
2,4-Dichloro-3-iodopyridine structure
CAS No.
343781-36-2
Chemical Name:
2,4-Dichloro-3-iodopyridine
Synonyms
Pyridine, 2,4-dichloro-3-iodo-
CBNumber:
CB21471058
Molecular Formula:
C5H2Cl2IN
Molecular Weight:
273.89
MDL Number:
MFCD09033756
MOL File:
343781-36-2.mol
MSDS File:
SDS
Last updated:2026-01-13 11:14:08
Product description Number Pack Size Price
2,4-Dichloro-3-iodopyridine 97% 721069 1g $52
2,4-Dichloro-3-iodopyridine D435258 100mg $60
2,4-Dichloro-3-iodopyridine D435258 500mg $110
2,4-Dichloro-3-iodopyridine W5591 5g $131
2,4-Dichloro-3-iodopyridine 98% 057338 5g $84
More product size
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2,4-Dichloro-3-iodopyridine Properties

Melting point 90-94 °C
Boiling point 290.3±35.0 °C(Predicted)
Density 2.129±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka -1.17±0.10(Predicted)
form solid
Appearance Off-white to light yellow Solid
InChI 1S/C5H2Cl2IN/c6-3-1-2-9-5(7)4(3)8/h1-2H
InChIKey OKXJLNYZTJLVJZ-UHFFFAOYSA-N
SMILES Clc1ccnc(Cl)c1I
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P301+P312+P330-P305+P351+P338+P310
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26-39
RIDADR  UN 2811
WGK Germany  3
HazardClass  IRRITANT
HS Code  2933399990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

2,4-Dichloro-3-iodopyridine price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 721069 2,4-Dichloro-3-iodopyridine 97% 343781-36-2 1g $52 2023-01-07 Buy
TRC D435258 2,4-Dichloro-3-iodopyridine 343781-36-2 100mg $60 2021-12-16 Buy
TRC D435258 2,4-Dichloro-3-iodopyridine 343781-36-2 500mg $110 2021-12-16 Buy
AK Scientific W5591 2,4-Dichloro-3-iodopyridine 343781-36-2 5g $131 2021-12-16 Buy
Matrix Scientific 057338 2,4-Dichloro-3-iodopyridine 98% 343781-36-2 5g $84 2021-12-16 Buy
Product number Packaging Price Buy
721069 1g $52 Buy
D435258 100mg $60 Buy
D435258 500mg $110 Buy
W5591 5g $131 Buy
057338 5g $84 Buy

2,4-Dichloro-3-iodopyridine Chemical Properties,Uses,Production

Uses

2,4-Dichloro-3-iodopyridine can be used as a pharmaceutical synthesis intermediate. It is prepared by reacting 2,4-dichloropyridine with n-butyllithium and iodine, and can be used to prepare another intermediate, 2,4-dichloro-3-trifluoromethylpyridine. It can also be obtained by iodination of 2,4-dichloropyridine or by chlorination of 2,4-dihydroxy-3-iodopyridine with phosphorus oxychloride.

Synthesis

2,4-Dichloropyridine

26452-80-2

2,4-Dichloro-3-iodopyridine

343781-36-2

General procedure for the synthesis of 2,4-dichloro-3-iodopyridine from 2,4-dichloropyridine: To a solution of anhydrous tetrahydrofuran (THF, 40 mL) of 2,4-dichloropyridine (5.2 g, 35.137 mmol) and N,N-diisopropylethylamine (DIPEA, 3.911 g, 38.651 mmol), the solution was cooled to -50 °C under nitrogen protection. At -78 °C, n-butyllithium (n-BuLi, 24.157 mL, 38.651 mmol, 1.6 M in hexane solution) was added dropwise. The reaction mixture was stirred at -78 °C for 45 min. Subsequently, a solution of iodine (9.81 g, 38.651 mmol) in anhydrous THF (20 mL) was added dropwise. The mixture was continued to be stirred at -78 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature, diluted with ethyl acetate (EtOAc) and the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) and saturated aqueous sodium thiosulfate (Na2S2O3). The organic layer was separated, the organic extracts were combined, washed with saturated aqueous sodium bicarbonate (NaHCO3), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel as stationary phase, heptane/dichloromethane gradient elution, dichloromethane up to 20%). The fraction containing the target product was collected and concentrated under reduced pressure to afford the intermediate compound 2,4-dichloro-3-iodopyridine (D5, 7.8 g, 81% yield).

References

[1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[2] Patent: WO2010/130422, 2010, A1. Location in patent: Page/Page column 53
[3] Patent: WO2010/130423, 2010, A1. Location in patent: Page/Page column 53
[4] Patent: WO2010/130424, 2010, A1. Location in patent: Page/Page column 104-105
[5] Patent: WO2012/62752, 2012, A1. Location in patent: Page/Page column 26

2,4-Dichloro-3-iodopyridine Preparation Products And Raw materials

Raw materials

2,4-Dichloropyridine iodine Tetrahydrofuran N,N-Diisopropylethylamine Hexane
n-Butyllithium

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Preparation Products

2,4-Dichloropyridine-3-carboxylic acid

2,4-Dichloro-3-iodopyridine Suppliers

Global( 127)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Didu New Materials Co. Ltd 		+86-86-17392712779 +8617392712697 1022@dideu.com China 8401 58
PNP Biotech Co. Ltd 		+8618516098983 sales@pnpbiotech.com China 1001 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29822 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8828 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Supplier Advantage
Shaanxi Didu New Materials Co. Ltd 		58
PNP Biotech Co. Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
SIMAGCHEM CORP 		58

View Lastest Price from 2,4-Dichloro-3-iodopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Dichloro-3-iodopyridine pictures 2025-09-25 2,4-Dichloro-3-iodopyridine
343781-36-2
 US $1.50 / g 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
2,4-Dichloro-3-iodopyridine pictures 2024-03-28 2,4-Dichloro-3-iodopyridine
343781-36-2
 US $0.00 / kg 25kg 98% Inquiry PNP Biotech Co. Ltd
2,4-Dichloro-3-iodopyridine pictures 2019-07-06 2,4-Dichloro-3-iodopyridine
343781-36-2
 US $1.00 / kg 1kg 98% 200KG Career Henan Chemical Co

2,4-Dichloro-3-iodopyridine Spectrum

2,4-Dichloro-3-iodopyridine(343781-36-2)1HNMR

343781-36-2(2,4-Dichloro-3-iodopyridine)Related Search:

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Pyridine, 2,4-dichloro-3-iodo- 343781-36-2 Heterocycle-Pyridine series