2-Amino-5-chloropyridine-3-carboxylic acid
- CAS No.
- 58584-92-2
- Chemical Name:
- 2-Amino-5-chloropyridine-3-carboxylic acid
- Synonyms
- 100006;2-Amino-6-chloronicotinic...;2-Amino-6-chloronicotinic acid 97%;58584-92-2;2-Amino-6-chloropyridine-3-carboxylicacid;2-Amino-6-chloropyridin-3-carboxylic acid;2-Amino-6-chloro-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 2-aMino-6-chloro-
- CBNumber:
- CB21471104
- Molecular Formula:
- C6H5ClN2O2
- Molecular Weight:
- 172.57
- MDL Number:
- MFCD11045328
- MOL File:
- 58584-92-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Amino-6-chloropyridine-3-carboxylic acid 97% | 772488 | 500mg | $81.8 |
| 2-Amino-6-chloronicotinic acid | 4H57-5-09 | 5g | $250 |
| 2-Amino-6-chloronicotinic acid | 4H57-5-09 | 25g | $750 |
| 2-Amino-6-chloronicotinic acid | 046233 | 5.00g | $75 |
| 2-Amino-6-chloronicotinic acid | 046233 | 10.00g | $88 |
| More product size | |||
| Melting point | 195-197°(dec) |
|---|---|
| Boiling point | 383.3±42.0 °C(Predicted) |
| Density | 1.577±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | 3.98±0.10(Predicted) |
| Appearance | Off-white to light brown Solid |
| InChIKey | INERBKPRIWEQRQ-UHFFFAOYSA-N |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2936290000 |
2-Amino-5-chloropyridine-3-carboxylic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 772488 | 2-Amino-6-chloropyridine-3-carboxylic acid 97% | 58584-92-2 | 500mg | $81.8 | 2023-01-07 | Buy |
| SynQuest Laboratories | 4H57-5-09 | 2-Amino-6-chloronicotinic acid | 58584-92-2 | 5g | $250 | 2026-05-22 | Buy |
| SynQuest Laboratories | 4H57-5-09 | 2-Amino-6-chloronicotinic acid | 58584-92-2 | 25g | $750 | 2026-05-22 | Buy |
| Matrix Scientific | 046233 | 2-Amino-6-chloronicotinic acid | 58584-92-2 | 5.00g | $75 | 2026-05-18 | Buy |
| Matrix Scientific | 046233 | 2-Amino-6-chloronicotinic acid | 58584-92-2 | 10.00g | $88 | 2026-05-18 | Buy |
2-Amino-5-chloropyridine-3-carboxylic acid Chemical Properties,Uses,Production
Uses
2-Amino-6-chloronicotinic Acid is a useful synthetic intermediate. It is used in the synthesis of thiamine antagonist transketolase inhibitors. It is also used to prepare 2-aminonicotinic acid 1-oxides as inhibitors of quinolinic acid synthesis in the mammalian brain.
Synthesis
38496-18-3
58584-92-2
The general procedure for the synthesis of 2-amino-6-chloronicotinic acid (Inter.2) using 2,6-dichloronicotinic acid (Inter.I) as starting material is as follows: 1. 2,6-dichloronicotinic acid (Inter.I) (1 equiv.) was mixed with liquid ammonia to prepare a 0.6 M ammonia solution. 2. The suspension is transferred to a pressure vessel, sealed and slowly heated to 130°C. At this temperature, the system pressure reaches 18 bar. 3. The temperature and pressure conditions were maintained for 16 hours. 4. upon completion of the reaction, cool the mixture to room temperature. 5. carefully open the pressure vessel and pour the reaction mixture into ice-cold water (in the same volume as the volume of reactants). 6. Acidify the solution to pH 1-2 using concentrated hydrochloric acid, at which point a precipitate is formed. 7. Warm the acidic mixture to room temperature and continue stirring for 30 minutes. 8. Extract the suspension with ether (400 ml each time, 3 times). 9. The organic extracts were combined, filtered and the filtrate was concentrated under vacuum to give a white solid. 10. The resulting solid was dried over P2O5 to afford the target compound 2-amino-6-chloronicotinic acid (Inter.2) in 90% yield and 96% purity. The product can be used directly without further purification. Mass spectral data: m/z (LC-MS ESP): 173 [M + H]+, retention time R/T = 3.63 min.
References
[1] Patent: WO2016/198400, 2016, A1. Location in patent: Page/Page column 65
[2] Patent: WO2007/60404, 2007, A1. Location in patent: Page/Page column 57-58
[3] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 99
[4] Patent: US2009/99174, 2009, A1
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1212 - 1216
2-Amino-5-chloropyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Nanjing Fred Technology Co., Ltd. | +86-02584696168 15380713688 | Austin@fredchem.cn | CHINA | 865 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
View Lastest Price from 2-Amino-5-chloropyridine-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-Amino-5-chloropyridine-3-carboxylic acid
58584-92-2
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
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- 2-Amino-5-chloropyridine-3-carboxylic acid
58584-92-2
- $1.00
- 99%
- Career Henan Chemical Co
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