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2-Amino-5-chloropyridine

2-Amino-5-chloropyridine Structure
2-Amino-5-chloropyridine structure
CAS No.
1072-98-6
Chemical Name:
2-Amino-5-chloropyridine
Synonyms
5-CHLOROPYRIDIN-2-AMINE;5-CHLORO-2-AMINOPYRIDINE;80.8;AKOS 91155;TIMTEC-BB SBB000059;5-Chlor-2-pyridylamin;5-CHLORO-A-PYRIDYLAMINE;5-CHLORO-2-PYRIDYLAMINE;5-CHLORO-2-PYRIDINAMINE;2-Amino-5-Cloropyridine
CBNumber:
CB0736206
Molecular Formula:
C5H5ClN2
Molecular Weight:
128.56
MDL Number:
MFCD00006324
MOL File:
1072-98-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:50:43
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2-Amino-5-chloropyridine Properties

Melting point 135-138 °C (lit.)
Boiling point 127-128 °C/11 mmHg (lit.)
Density 1.2417 (rough estimate)
refractive index 1.5110 (estimate)
Flash point 160 °C
storage temp. 2-8°C
solubility 1.0g/l
pka 4.67±0.13(Predicted)
form Crystalline Powder
color Beige to beige-brown
Water Solubility 1 g/L (20 ºC)
BRN 108735
InChI 1S/C5H5ClN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
InChIKey MAXBVGJEFDMHNV-UHFFFAOYSA-N
SMILES Nc1ccc(Cl)cn1
CAS DataBase Reference 1072-98-6(CAS DataBase Reference)
NIST Chemistry Reference 2-Amino-5-chloropyridine(1072-98-6)
EPA Substance Registry System 2-Amino-5-chloropyridine (1072-98-6)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H302-H312-H332-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P280h-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  22-24/25-37/39-26-36
WGK Germany  3
Hazard Note  Harmful
HazardClass  IRRITANT
HS Code  29333999
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
1 0

2-Amino-5-chloropyridine price More Price(86)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A46803 2-Amino-5-chloropyridine 98% 1072-98-6 25g $28.9 2026-04-30 Buy
Sigma-Aldrich BP813 2-Amino-5-chloropyridine British Pharmacopoeia (BP) Reference Standard 1072-98-6 25MG $274 2026-04-30 Buy
Sigma-Aldrich A46803 2-Amino-5-chloropyridine 98% 1072-98-6 100g $88.2 2026-04-30 Buy
TCI Chemical A0837 2-Amino-5-chloropyridine >98.0%(GC)(T) 1072-98-6 25g $22 2026-04-30 Buy
TCI Chemical A0837 2-Amino-5-chloropyridine >98.0%(GC)(T) 1072-98-6 100g $77 2026-04-30 Buy
Product number Packaging Price Buy
A46803 25g $28.9 Buy
BP813 25MG $274 Buy
A46803 100g $88.2 Buy
A0837 25g $22 Buy
A0837 100g $77 Buy

2-Amino-5-chloropyridine Chemical Properties, Uses, Production

Synthesis

Based on the structural analysis of 2-amino-5-chloropyridine, a synthetic route was designed. 2-amino-5-chloropyridine was prepared from 2-aminopyridine as a starting material. The target compound was obtained through nitration, amidation, and reduction reactions. The synthetic reaction formula for 2-amino-5-chloropyridine is shown in the figure below:

Synthesis of 1072-98-6

Chemical Properties

beige to beige-brown crystalline powder

Uses

5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.

Reactions

2-Amino-5-chloropyridine can be used to electro-organically synthesize 6-aminonicotinic acid. 6-aminonicotinic acid is the main component of vitamin B3 and can be used to treat pellagra. The specific method is as follows:
In the presence of sulfuric acid and carbon dioxide, in dimethylformamide (DMF) solution, 5-chloro-2-nitropyridine 1 is electrochemically converted to 2-amino-5-chloropyridine 2 on a nickel cathode and a copper anode at an apparent current density of 10 mA/cm2 using a diaphragmless electrolytic cell, with a yield of up to 84%. Then 2 is reductively carboxylated to synthesize 6-aminonicotinic acid 3 on the cathode surface with a yield of 78%.
Reaction of 2-Amino-5-chloropyridine

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 93, 1976 DOI: 10.1021/jo00863a020

Toxicology

2-Amino-5-chloropyridine is an irritant, causing severe eye irritation, possibly skin and respiratory irritation, and harmful if ingested. The substance is non-mutagenic, but has a relatively high toxicity to zebrafish embryonic development, with embryonic malformation and mortality rates being concentration-dependent.

Purification Methods

Recrystallise this base from pet ether. It sublimes at 50o/0.5mm. [Beilstein 22 II 332, 22/8 V 541.]

2-Amino-5-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Zopiclone 5-Chloro-2-hydroxy-3-nitropyridine 2,5-Dichloro-3-nitropyridine 2,5-Dichloropyridin-3-amine ethyl 2-(6-aminopyridin-3-yl)acetate
6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine EthanediaMide iMpurity F 2-Bromo-5-chloropyridine 2-Bromo-5-chloro-3-nitropyridine 2-Amino-5-chloro-3-nitropyridine
3-Amino-2-bromo-5-chloropyridine 5-Chloropyridine-2-carboxylic acid

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2-Amino-5-chloropyridine Suppliers

Global Suppliers ( 839)
Supplier Tel Email Country ProdList Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
Jinan Dexinjia Bio&Tech Co., Ltd 0531-82375880 15098789112 3845379039@qq.com China 1458 58
Shanghai Taijilin Industrial Co., Ltd. 02150630626 17717886015 kate@tajilin.com China 1340 58
Beijing Wisdom Chemicals Co., Ltd. 85795078 13910917337 mei@wisdomchem.com China 254 58
Changzhou Yuxiang Chemical Co., Ltd 13809076511 344679571@qq.com China 311 58
Jiangxi Bairui Technology Co., Ltd 13026208279 13026208279 bwinchem@163.com China 186 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Supplier Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
Jinan Dexinjia Bio&Tech Co., Ltd 58
Shanghai Taijilin Industrial Co., Ltd. 58
Beijing Wisdom Chemicals Co., Ltd. 58
Changzhou Yuxiang Chemical Co., Ltd 58
Jiangxi Bairui Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69

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View Latest Price from 2-Amino-5-chloropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-5-chloropyridine pictures 2026-09-15 2-Amino-5-chloropyridine
1072-98-6
 1KG 99%min 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
2-Amino-5-chloropyridine pictures 2026-09-15 2-Amino-5-chloropyridine
1072-98-6
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2-Amino-5-chloropyridine pictures 2026-09-02 2-Amino-5-chloropyridine
1072-98-6
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2-Amino-5-chloropyridine Spectrum

2-Amino-5-chloropyridine(1072-98-6)MS2-Amino-5-chloropyridine(1072-98-6)1HNMR2-Amino-5-chloropyridine(1072-98-6)13CNMR2-Amino-5-chloropyridine(1072-98-6)IR12-Amino-5-chloropyridine(1072-98-6)IR22-Amino-5-chloropyridine(1072-98-6)Raman

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2-Amino-5-chloropyridine  5-Chloro-2-pyridineamine 5-Chloro-a-aminopyridine 2-Amino-5-chloropyridine ,98% 2-AMINO-5-CHLOROPYRIDINE 5-CHLORO-PYRIDIN-2-YLAMINE 2-Amino-5-chlorophridine 2-AMINO-5-CHLOROPYRIDINE FOR SYNTHESIS 2-aMino -5-chlorine pyridine TIMTEC-BB SBB000059 2-Pyridinamine, 5-chloro- Pyridine, 2-amino-5-chloro- AMINO(2-)-5-CHLOROPYRIDINE AKOS 91155 5-CHLOROPYRIDIN-2-YLAMINE 5-CHLORO-A-PYRIDYLAMINE 5-CHLORO-2-PYRIDYLAMINE 5-CHLORO-2-PYRIDINAMINE 5-CHLORO-2-AMINOPYRIDINE 2-AMINO-5-CHLIROPYRIDINE 2-Pyridinamine,5-chloro-(9CI) 2-Amino-5-Chloro Pyriine 2-AMINO-5-CHLOROPYRIDINE 99% 2-Amino-5-chloropyridine HPLC 99.5%Individual impurity = NMT 0.10 % 2-Amino-5-chloropyridine > 2-Bromo-3-Chloro-7-(Trifluoromethyl)Pyridine 2-Amino-5-chloropyridine ISO 9001：2015 REACH Edoxaban Impurity 37 / Zopiclone Impurity 1 5-Chlor-2-pyridylamin 2-Amino-5-Cloropyridine 2-Amino-5-chloropyridine 2 mino-5-chloropyridine 2-Amino-5-chloropyridine, 95% 80.8 2-Amino-5-chloropyridine - [A16397] Zopiclone Impurity: 2-Amino-5-chloropyridine 5-CHLOROPYRIDIN-2-AMINE 1072-98-6 C5H5CIN2 C5H5N2Cl Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Halopyridines Chloropyridines Pyridines FINE Chemical & INTERMEDIATES Amines blocks PYRIDINE Nitrogen cyclic compounds Heterocycle-Pyridine series amine| alkyl chloride Pyridines derivates Chloropyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks