3-chloro-4-(pyridin-2-ylmethoxy)aniline
- CAS No.
- 524955-09-7
- Chemical Name:
- 3-chloro-4-(pyridin-2-ylmethoxy)aniline
- Synonyms
- AKOS B033273;3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline;3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE;methoxy)aniL;oro-4-(2-pyridyL;ART-CHEM-BB B033273;Neratinib Impurity 41;Neratinib Intermediate1;UKRORGSYN-BB BBV-019513;AKOS B033273(524955-09-7)
- CBNumber:
- CB4801557
- Molecular Formula:
- C12H11ClN2O
- Molecular Weight:
- 234.68
- MDL Number:
- MFCD08699389
- MOL File:
- 524955-09-7.mol
- MSDS File:
- SDS
| Melting point | 91.0 to 95.0 °C |
|---|---|
| Boiling point | 402.5±35.0 °C(Predicted) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 3.88±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C12H11ClN2O/c13-11-7-9(14)4-5-12(11)16-8-10-3-1-2-6-15-10/h1-7H,8,14H2 |
| InChIKey | XCAPJQSICQSUJP-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(OCC2=NC=CC=C2)C(Cl)=C1 |
| FDA UNII | 67KD7Z8H49 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
3-chloro-4-(pyridin-2-ylmethoxy)aniline price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3150 | 3-Chloro-4-(2-pyridylmethoxy)aniline >98.0%(GC)(T) | 524955-09-7 | 1g | $110 | 2026-04-30 | Buy |
| TCI Chemical | C3150 | 3-Chloro-4-(2-pyridylmethoxy)aniline >98.0%(GC)(T) | 524955-09-7 | 5g | $328 | 2026-04-30 | Buy |
| Apolloscientific | OR55641 | 3-Chloro-4-(pyridin-2-ylmethoxy)aniline >98% | 524955-09-7 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR55641 | 3-Chloro-4-(pyridin-2-ylmethoxy)aniline >98% | 524955-09-7 | 25g | $48 | 2026-06-04 | Buy |
| Apolloscientific | OR55641 | 3-Chloro-4-(pyridin-2-ylmethoxy)aniline >98% | 524955-09-7 | 100g | $138 | 2026-06-04 | Buy |
3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties, Uses, Production
Uses
3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.
Synthesis
3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL).
The mixture was stirred at 60° C. overnight.
Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate.
The organic phase was separated, washed with saturated brine and dried.
The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained.
1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).
References
[1] Patent: US2016/214964, 2016, A1. Location in patent: Paragraph 0140
[2] Patent: US2006/270668, 2006, A1. Location in patent: Page/Page column 16-17
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 11, p. 3090 - 3104
[4] Patent: WO2009/33581, 2009, A1. Location in patent: Page/Page column 60-61
3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan XuanDe Chemical Co., Ltd. | 0531-88803958 19862127196 | zhangxu@shiningpharm.com | China | 202 | 58 |
| Anqing CHICO Pharmaceutical Co., Ltd. | 18061456370 | david@chicopharm.com | China | 461 | 58 |
| TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. | 022-60189726 18812034280 | 188120342808@163.com | China | 143 | 61 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
View Latest Price from 3-chloro-4-(pyridin-2-ylmethoxy)aniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
|
100g | 98%min | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-06-30 | 3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- 3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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