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Ethyl (3-fluorobenzoyl)acetate

Ethyl (3-fluorobenzoyl)acetate structure

CAS No.: 33166-77-7

Chemical Name:: Ethyl (3-fluorobenzoyl)acetate

Synonyms: ETHYL 3-(3-FLUOROPHENYL)-3-OXOPROPANOATE;Ethyl m-fluorobenzoyl acetate;ETHYL (3-FLUOROBENZOYL)ACETATE;Ethyl 2-3-fluorobenzoylacetate;Ethyl 3-fluoro-β-oxobenzenepropanoate;(m-Fluorobenzoyl)acetic acid ethyl ester;3-(3-Fluorophenyl)-3-oxopropanoic acid ethyl ester;Benzenepropanoic acid, 3-fluoro-β-oxo-, ethyl ester;Benzenepropanoic acid, 3-fluoro-β-oxo-, ethyl ester;3-（3-Fluoro-phenyl）-3-oxo-propionic acid ethyl bster

CBNumber:: CB2148920

Molecular Formula:: C11H11FO3

Molecular Weight:: 210.2

MDL Number:: MFCD03424809

MOL File:: 33166-77-7.mol

MSDS File:: SDS

Last updated:2026-05-27 23:56:12

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Ethyl (3-fluorobenzoyl)acetate Properties

Boiling point	262-263 °C(lit.)
Density	1.166 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5172(lit.)
Flash point	>230 °F
storage temp.	Sealed in dry,Room Temperature
form	Liquid
pka	10.10±0.46(Predicted)
color	Colorless to orange
InChI	1S/C11H11FO3/c1-2-15-11(14)7-10(13)8-4-3-5-9(12)6-8/h3-6H,2,7H2,1H3
InChIKey	MLABEWHVTXMKHP-UHFFFAOYSA-N
SMILES	CCOC(=O)CC(=O)c1cccc(F)c1
CAS DataBase Reference	33166-77-7(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

PPE

Eyeshields, Gloves

WGK Germany

TSCA

Yes

HS Code

2916399090

Storage Class

10 - Combustible liquids

NFPA 704

	1
0		0

Ethyl (3-fluorobenzoyl)acetate price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	559237	Ethyl (3-fluorobenzoyl)acetate	33166-77-7	1g	$96.1	2023-06-20	Buy
Sigma-Aldrich	559237	Ethyl (3-fluorobenzoyl)acetate	33166-77-7	5g	$230	2023-01-07	Buy
Apolloscientific	PC1849	Ethyl 3-(3-fluorophenyl)-3-oxopropanoate >97%	33166-77-7	100mg	$21	2026-06-04	Buy
Apolloscientific	PC1849	Ethyl 3-(3-fluorophenyl)-3-oxopropanoate >97%	33166-77-7	250mg	$24	2026-06-04	Buy
Apolloscientific	PC1849	Ethyl 3-(3-fluorophenyl)-3-oxopropanoate >97%	33166-77-7	1g	$26	2026-06-04	Buy

Product number	Packaging	Price	Buy
559237	1g	$96.1	Buy
559237	5g	$230	Buy
PC1849	100mg	$21	Buy
PC1849	250mg	$24	Buy
PC1849	1g	$26	Buy

Ethyl (3-fluorobenzoyl)acetate Chemical Properties, Uses, Production

Uses

Reactant for:

Preparation of biologically active molecules

Synthesis

To a stirring suspension of NaH and CO(OEt)2 in toluene was added dropwise a solution of substituted acetophenone in toluene under reflux. The mixture was allowed to reflux and was stirred for 20 min after the addition was complete. When cooled to room temperature, the mixture was acidified with glacial HOAc. After ice-cold water was added, the mixture was extracted with toluene. The extract was then dried over anhydrous MgS04. After the toluene was evaporated in vacuo to give the corresponding substituted Ethyl (3-fluorobenzoyl)acetate.

References

[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5064 - 5075
[2] Patent: WO2014/179401, 2014, A1. Location in patent: Page/Page column 9; 14; 15
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 19, p. 3049 - 3056
[4] European Journal of Organic Chemistry, 2015, vol. 2015, # 17, p. 3656 - 3660
[5] Chemical Communications, 2017, vol. 53, # 58, p. 8136 - 8139

Ethyl (3-fluorobenzoyl)acetate Preparation Products And Raw materials

Raw materials

3'-Fluoroacetophenone Diethyl carbonate Sodium hydride Toluene Mineral oil

Preparation Products

ethyl(S)-3-amino-3-(3-fluorophenyl)propanoate

Ethyl (3-fluorobenzoyl)acetate Suppliers

Global Suppliers ( 158)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanbu County Chengxin Technology Co., Ltd.	0838-5675166 15883665058	nbcxkj@126.com	China	956	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Shanghai Sphchem Co., Ltd.	021-56491756 13512199871	2819742715@qq.com	China	3994	55
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55

Supplier	Advantage
Nanbu County Chengxin Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shanghai Hanhong Scientific Co.,Ltd.	64
Syntechem Co.,Ltd	57
Shanghai Sphchem Co., Ltd.	55
Shanghai Jian Chao Chemical Technology Co., Ltd.	55

View Latest Price from Ethyl (3-fluorobenzoyl)acetate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-03-20	3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 33166-77-7		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
	2019-12-24	3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 33166-77-7	$1.00	100EA	98%min		Career Henan Chemical Co

3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
33166-77-7
99%
Hebei Chuanghai Biotechnology Co., Ltd

3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
33166-77-7
$1.00
98%min
Career Henan Chemical Co

Ethyl (3-fluorobenzoyl)acetate Spectrum

Ethyl (3-fluorobenzoyl)acetate(33166-77-7)¹HNMR Ethyl (3-fluorobenzoyl)acetate(33166-77-7)IR

33166-77-7 (Ethyl (3-fluorobenzoyl)acetate) Related Search:

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3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER ETHYL (3-FLUOROBENZOYL)ACETATE (m-Fluorobenzoyl)acetic acid ethyl ester 3-(3-Fluorophenyl)-3-oxopropanoic acid ethyl ester Ethyl 2-3-fluorobenzoylacetate Ethyl 3-fluoro-β-oxobenzenepropanoate Ethyl m-fluorobenzoyl acetate Benzenepropanoic acid, 3-fluoro-β-oxo-, ethyl ester 3-（3-Fluoro-phenyl）-3-oxo-propionic acid ethyl bster Benzenepropanoic acid, 3-fluoro-β-oxo-, ethyl ester ETHYL 3-(3-FLUOROPHENYL)-3-OXOPROPANOATE 33166-77-7 FC6H4COCH2CO2C2H5 Esters Organic Building Blocks C10 to C11 Carbonyl Compounds Building Blocks C10 to C11 Carbonyl Compounds Esters