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JWZ-7-7-Neg1

JWZ-7-7-Neg1 structure

CAS No.: 3008612-30-1

Chemical Name:: JWZ-7-7-Neg1

Synonyms: JWZ-7-7-Neg1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N-[7-[[[1-[5-chloro-4-[[1,2-dihydro-8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-6-quinolinyl]amino]-2-pyrimidinyl]-4-piperidinyl]carbonyl]amino]heptyl]-4-(4-chlorophenyl)-2,3,9-trimethyl-, (6R)-

CBNumber:: CB214907797

Molecular Formula:: C50H58Cl2N12O6S

Molecular Weight:: 1026.05

MDL Number:

MOL File:: 3008612-30-1.mol

Last updated:2025-04-17 18:22:24

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JWZ-7-7-Neg1 Properties

Density	1.444±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

JWZ-7-7-Neg1 Chemical Properties, Uses, Production

Uses

JWZ-7-7-Neg1 is a transcriptional chemical inducers of proximity (TCIP) with negative chemical control. JWZ-7-7-Neg1 reduces the ability to bind to BRD4 or BCL6, so it has less cytotoxicity to DLBCL cells, in compared with JWZ-7-7[1].

References

[1] Crabtree GR, et al., Compositions, systems, and methods for modulating a target gene. WO2023215311.

JWZ-7-7-Neg1 Preparation Products And Raw materials

Raw materials

Preparation Products

3008612-30-1 (JWZ-7-7-Neg1) Related Search:

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1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea

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JWZ-7-7-Neg1 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N-[7-[[[1-[5-chloro-4-[[1,2-dihydro-8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-6-quinolinyl]amino]-2-pyrimidinyl]-4-piperidinyl]carbonyl]amino]heptyl]-4-(4-chlorophenyl)-2,3,9-trimethyl-, (6R)- 3008612-30-1