Glycochenodeoxycholic Acid
- CAS No.
- 640-79-9
- Chemical Name:
- Glycochenodeoxycholic Acid
- Synonyms
- GCDCA;Glycochenodeoxycholate;GCDC;Chenodeoxycholylglycine;Glycinodeoxycholic acid;glycochenodeoxycholic aci;Glycine chenodeoxycholate;GLYCOCHENODEOXYCHOLIC ACID;Glycoanthropodeoxycholic acid;Glycochenodeoxycholic-d4 Acid
- CBNumber:
- CB32130584
- Molecular Formula:
- C26H43NO5
- Molecular Weight:
- 449.62
- MDL Number:
- MFCD00271498
- MOL File:
- 640-79-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 655.6±40.0 °C(Predicted) |
|---|---|
| Density | 1.162±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 29 mg/mL (64.50 mM) |
| pka | 3.58±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | GHCZAUBVMUEKKP-VHGKAQQHNA-N |
| SMILES | C(O)(=O)CNC(=O)CC[C@@H](C)[C@@H]1[C@]2(CCC3[C@]4(C)[C@]([H])(C[C@@H](O)C3C2CC1)C[C@H](O)CC4)C |&1:9,11,12,16,18,21,28,r| |
| FDA UNII | 451ZNJ667Y |
| UNSPSC Code | 12352211 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P260-P264-P270-P271-P280-P301+P310-P321-P330-P303+P361+P353-P304+P340-P307+P311-P312-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Glycochenodeoxycholic Acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 31363 | Glycochenodeoxycholic Acid MaxSpec® Standard ≥95% | 640-79-9 | 100μg | $75 | 2026-04-30 | Buy |
| Biosynth | FG172125 | Glycochenodeoxycholic acid | 640-79-9 | 10g | $280.3 | 2026-06-04 | Buy |
| Biosynth | FG172125 | Glycochenodeoxycholic acid | 640-79-9 | 25g | $583.75 | 2026-06-04 | Buy |
| Biosynth | FG172125 | Glycochenodeoxycholic acid | 640-79-9 | 50g | $1061.5 | 2026-06-04 | Buy |
| Biosynth | FG172125 | Glycochenodeoxycholic acid | 640-79-9 | 100g | $1911 | 2026-06-04 | Buy |
Glycochenodeoxycholic Acid Chemical Properties, Uses, Production
Uses
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC)[1][2][3][4].
Definition
ChEBI: A bile acid glycine conjugate having 3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl as the bile acid component.
IC 50
Microbial Metabolite; Human Endogenous Metabolite
References
[1] Lan W, et al. Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells[J]. Toxicol Lett. 2020 Oct 1;331:11-21. DOI:10.1016/j.toxlet.2020.05.017
[2] Wang A, et al. Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts[J]. J Clin Exp Hepatol. 2017 Dec;7(4):316-320. DOI:10.1016/j.jceh.2017.04.002
[3] Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27. DOI:10.1023/a:1007021710825
[4] Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. DOI:10.18632/aging.103751
Glycochenodeoxycholic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| NOTA Chemical (Shanghai) Co.,Ltd | 021-50189163 | sales@notachem.com | China | 208 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Glycochenodeoxycholic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Glycinodeoxycholic acid
640-79-9
|
1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd | ||
 |
2026-07-27 | Glycochenodeoxycholic Acid
640-79-9
|
$30.00-76.00 | 97.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-22 | Glycochenodeoxycholic Acid
640-79-9
|
$2.00 | 1kg | 99.99 | 1000000 | Anhuyan (Hainan) Biotechnology Co., LTD |
-
- Glycinodeoxycholic acid
640-79-9
- $0.00
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- Glycochenodeoxycholic Acid
640-79-9
- $30.00-76.00
- 97.00%
- TargetMol Chemicals Inc.
-
- Glycochenodeoxycholic Acid
640-79-9
- $2.00
- 99.99
- Anhuyan (Hainan) Biotechnology Co., LTD
