CW-3308
- CAS No.
- 3055592-99-6
- Chemical Name:
- CW-3308
- Synonyms
- CW-3308
- CBNumber:
- CB214907898
- Molecular Formula:
- C45H48N6O8
- Molecular Weight:
- 800.9
- MDL Number:
- MOL File:
- 3055592-99-6.mol
- MSDS File:
- SDS
CW-3308 Chemical Properties, Uses, Production
Uses
CW-3308 is an orally effective PROTAC that selectively targets BRD9 and is expected to be used to inhibit synovial sarcoma, rhabdomyoma, and other BRD9-dependent human diseases. CW-3308 is composed of PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH (HY-159596) (red part), Linker 3-Azaspiro[5.5]undecane-9-methanol (HY-159598) (black part), E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine (HY-159597) (blue part), where the conjugate of E3 ubiquitin ligase ligand + linker is Thalidomide-pyrrolidine-C-azaspiro (HY-159599)[1].
References
[1] Wang C, et al. Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9. J Med Chem. 2024 Aug 22;67(16):14125-14154. DOI:10.1021/acs.jmedchem.4c00971
CW-3308 Preparation Products And Raw materials
Raw materials
Preparation Products
CW-3308 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Junepharma Technology Co., Ltd | 19181793067 | 1486288711@qq.com | China | 250 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2445 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Jiangsu Magic Biotechnology Co., Ltd | 13685102975 13921770081 | svp01@magicbiotech.cn | China | 498 | 58 |
| Soochow Chirally Material Science and Technology Co.,Ltd | 0512-66834346 17751187418 | sales@krl-tech.com | China | 1283 | 58 |
| Zhengzhou Runkai Pharmaceutical Technology Co., Ltd | 19137644811 | 3649307081@qq.com | China | 496 | 58 |
| Chengdu Yinchuangyuan Pharmaceutical Technology Co., Ltd | 18190710352 18190710352 | dy.zhang@increland.com | China | 56 | 58 |
| Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. | 13771642864 | snhuyu_2008@126.com | China | 1186 | 58 |
