4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
- CAS No.
- 877399-50-3
- Chemical Name:
- 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
- Synonyms
- CRIXOTINIB-D;1-Boc-4-(4-br;Crizotinib Impurity 4;1-(4-BOC-Piperidino)-4-bromopyrazole;1-Boc-4-(4-broMopyrazol-1-yl)piperidine;1-Boc-4-(4-bromo-1-pyrazolyl)piperidine;N-BOC-4-(4-BROMOPYRAZOL-1-YL)PIPERIDINE;1-(4-Boc-1-piperidinyl)-4-bromopyrazole;1-Boc-4-(4-bromo-1H-pyrazol-1-yl)piperidine;4-Bromo-1-(N-boc-piperidin-4-yl)-1H-pyrazole
- CBNumber:
- CB21504512
- Molecular Formula:
- C13H20BrN3O2
- Molecular Weight:
- 330.22
- MDL Number:
- MFCD09831980
- MOL File:
- 877399-50-3.mol
| Melting point | 77.0 to 81.0 °C |
|---|---|
| Boiling point | 411.5±35.0 °C(Predicted) |
| Density | 1.43 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 0.92±0.19(Predicted) |
| form | Solid |
| color | Off-white |
| CAS DataBase Reference | 877399-50-3 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4391 | tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate >98.0%(HPLC)(T) | 877399-50-3 | 1g | $58 | 2024-03-01 | Buy |
| TCI Chemical | B4391 | tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate >98.0%(HPLC)(T) | 877399-50-3 | 5g | $191 | 2024-03-01 | Buy |
| TRC | B662025 | 1-(4-BOC-Piperidino)-4-bromopyrazole | 877399-50-3 | 250mg | $55 | 2021-12-16 | Buy |
| Matrix Scientific | 083924 | tert-Butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate 97% | 877399-50-3 | 1g | $55 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB34117 | 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester | 877399-50-3 | 5G | $60 | 2021-12-16 | Buy |
4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production
Synthesis
2075-45-8
141699-59-4
877399-50-3
General procedure for the synthesis of tert-butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylate from 4-bromopyrazole and tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate: 2.08 kg of cesium carbonate and 0.78 kg of 4-bromopyrazole were dissolved in 4 liters of N-methyl pyrrolidinone, and heated to 80°C. Subsequently, 2.08 kg of cesium carbonate and 0.78 kg of 4-bromopyrazole were dissolved in 5 liters of N-methyl pyrrolidinone. 1.8 kg of tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate was added to the reaction mixture and the reaction lasted for 12 hours. After completion of the reaction, it was cooled to room temperature, 50 liters of methyl tert-butyl ether and 50 liters of water were added and stirred for 1 hour. After separating the organic phase, the organic phase was washed 4 times with 20 liters of water, then dried with 50% hexane and stirred for 2 hours at room temperature. Finally, it was filtered and dried to give 1.35 kg of tert-butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylate in 77% yield.
References
[1] Patent: CN106317024, 2017, A. Location in patent: Paragraph 0060; 0061
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 12, p. 4092 - 4108
[3] Patent: WO2015/81257, 2015, A2. Location in patent: Page/Page column 81
[4] Tetrahedron Letters, 2014, vol. 55, # 9, p. 1528 - 1531
[5] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 64-65
4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20185 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3971 | 58 |
View Lastest Price from 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate
877399-50-3
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-07-25 | 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
877399-50-3
|
US $0.00 / kg | 1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-01-03 | 1-(4-BOC-Piperidino)-4-broMopyrazole
877399-50-3
|
US $0.00-0.00 / KG | 10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate
877399-50-3
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
877399-50-3
- US $0.00 / kg
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-(4-BOC-Piperidino)-4-broMopyrazole
877399-50-3
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
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