2-amino-3-chloro-5-fluorobenzoic acid
- CAS No.
- 1022961-12-1
- Chemical Name:
- 2-amino-3-chloro-5-fluorobenzoic acid
- Synonyms
- Reaxys ID: 15860445;2-amino-3-chloro-5-fluorobenzoic acid;Benzoic acid, 2-amino-3-chloro-5-fluoro-
- CBNumber:
- CB21682955
- Molecular Formula:
- C7H5ClFNO2
- Molecular Weight:
- 189.57
- MDL Number:
- MFCD11193640
- MOL File:
- 1022961-12-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2922498590 |
2-amino-3-chloro-5-fluorobenzoic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XQB96112 | 2-amino-3-chloro-5-fluorobenzoic acid | 1022961-12-1 | 10g | $472 | 2026-06-05 | Buy |
| Biosynth | XQB96112 | 2-amino-3-chloro-5-fluorobenzoic acid | 1022961-12-1 | 100g | $3540 | 2026-06-05 | Buy |
| Apolloscientific | PC53092 | 2-Amino-3-chloro-5-fluorobenzoic acid 98% | 1022961-12-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC53092 | 2-Amino-3-chloro-5-fluorobenzoic acid 98% | 1022961-12-1 | 5g | $75 | 2026-06-04 | Buy |
| Apolloscientific | PC53092 | 2-Amino-3-chloro-5-fluorobenzoic acid 98% | 1022961-12-1 | 25g | $361 | 2026-06-04 | Buy |
2-amino-3-chloro-5-fluorobenzoic acid Chemical Properties, Uses, Production
Synthesis
446-08-2
1022961-12-1
General procedure for the synthesis of 2-amino-3-chloro-5-fluorobenzoic acid from 2-amino-5-fluorobenzoic acid: a mixture of 2-amino-5-fluorobenzoic acid (5.0 g, 32.26 mmol), N-chlorosuccinimide (NCS, 4.39 g, 32.9 mmol), and N,N-dimethylformamide (DMF, 30 mL) was stirred and reacted at room temperature for 16 hours. After completion of the reaction, the reaction solution was diluted with water (100 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The concentrated residue was stirred with dichloromethane (100 mL) for 10 min and filtered to afford the target product 2-amino-3-chloro-5-fluorobenzoic acid (3.4 g, 56% yield) as a gray solid.LC-MS (ESI): m/z = 190.0 ([M + H]+).
References
[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 6, p. 3163 - 3170
[2] Patent: US2016/244432, 2016, A1. Location in patent: Paragraph 0232; 0233
2-amino-3-chloro-5-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-amino-3-chloro-5-fluorobenzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4561 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Suzhou Chenke Biotech Co., Ltd. | 18662408853 | 2120408911@qq.com | China | 980 | 55 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7982 | 55 |
| parabiochem | 025-83453382-8005 | sale@parabiochem.com | China | 9577 | 55 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
