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2-Amino-5-fluorobenzoic acid

2-Amino-5-fluorobenzoic acid structure

CAS No.: 446-08-2

Chemical Name:: 2-Amino-5-fluorobenzoic acid

Synonyms: 5-FLUOROANTHRANILIC ACID;5-FAA;NSC 513308;AURORA KA-5382;BUTTPARK 19\04-54;RARECHEM AL BO 2236;5-Fluoranthranilsure;5-fluoroanthranilicaci;Zavegepant Impurity 74;2-Amino-5-fluorobenzoic

CBNumber:: CB2136554

Molecular Formula:: C7H6FNO2

Molecular Weight:: 155.13

MDL Number:: MFCD00055566

MOL File:: 446-08-2.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:50

Product description	Number	Pack Size	Price
2-Amino-5-fluorobenzoic acid 97%	367982	1g	$79.6
2-Amino-5-fluorobenzoic acid 97%	367982	10g	$504
5-Fluoroanthranilic Acid >98.0%(HPLC)(T)	F0396	1g	$38
5-Fluoroanthranilic Acid >98.0%(HPLC)(T)	F0396	5g	$123
2-Amino-5-fluorobenzoic Acid ≥98%	16669	1g	$49
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2-Amino-5-fluorobenzoic acid Properties

Melting point	181-183 °C(lit.)
Boiling point	223.67°C (rough estimate)
Density	1.3021 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	1.86±0.10(Predicted)
form	Fine Crystalline Powder
color	Light yellow to light brown
BRN	2803664
Major Application	peptide synthesis
InChI	InChI=1S/C7H6FNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey	FPQMGQZTBWIHDN-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC(F)=CC=C1N
CAS DataBase Reference	446-08-2(CAS DataBase Reference)
FDA UNII	5VD9746EAR
UNSPSC Code	12352106
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,T

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

HazardClass

IRRITANT

HS Code

29224999

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

2-Amino-5-fluorobenzoic acid price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	367982	2-Amino-5-fluorobenzoic acid 97%	446-08-2	1g	$79.6	2026-03-19	Buy
Sigma-Aldrich	367982	2-Amino-5-fluorobenzoic acid 97%	446-08-2	10g	$504	2026-03-19	Buy
TCI Chemical	F0396	5-Fluoroanthranilic Acid >98.0%(HPLC)(T)	446-08-2	1g	$38	2026-03-19	Buy
TCI Chemical	F0396	5-Fluoroanthranilic Acid >98.0%(HPLC)(T)	446-08-2	5g	$123	2026-03-19	Buy
Cayman Chemical	16669	2-Amino-5-fluorobenzoic Acid ≥98%	446-08-2	1g	$49	2024-03-01	Buy

Product number	Packaging	Price	Buy
367982	1g	$79.6	Buy
367982	10g	$504	Buy
F0396	1g	$38	Buy
F0396	5g	$123	Buy
16669	1g	$49	Buy

2-Amino-5-fluorobenzoic acid Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-5-fluorobenzoic acid is used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.

Uses

Used in the synthesis of styrylquinazolinones which are potential anticancer agents.

Definition

ChEBI: An aminobenzoic acid that is anthranilic acid in which the hydrogen at position 5 on the phenyl ring is replaced by fluorine.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

320-98-9

446-08-2

General procedure for the synthesis of 2-amino-5-fluorobenzoic acid from 2-nitro-5-fluorobenzoic acid: 2-nitro-5-fluorobenzoic acid (10 g, 54 mmol) was dissolved in ethanol (100 mL) and 10% Pd/C catalyst (0.5 g) was added. The reaction was stirred at room temperature for 4 h under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration. The filtrate was concentrated under reduced pressure to give 8.2 g (98% yield) of the white solid product 2-amino-5-fluorobenzoic acid. Product melting point: 142 °C. 1H NMR (DMSO-d6) δ: 6.71 (dd, J = 4.9, 8.9 Hz, 1H), 7.15 (dt, J = 2.9, 8.4 Hz, 1H), 7.37 (dd, J = 2.9, 9.8 Hz, 1H), 8.60 (s, 1H).EIMS m/z 156 (M + 1).

References

[1] Patent: WO2004/74218, 2004, A2. Location in patent: Page 106
[2] Patent: US2008/139551, 2008, A1. Location in patent: Page/Page column 43
[3] Patent: US2008/139551, 2008, A1. Location in patent: Page/Page column 44
[4] Patent: US5514676, 1996, A
[5] Journal of Biological Chemistry, 1954, vol. 207, p. 411,412

2-Amino-5-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

5-Fluoro-2-nitrobenzoic acid 2-Bromo-5-fluorobenzoic acid 5-Fluoroindole 2-ACETAMIDE-5-FLUOROTOLUENE 2-ACETAMIDO-5-FLUOROBENZOIC ACID

2-Amino-5-fluorobenzoic acid methyl ester 5-Fluoro-2-nitrotoluene 3-Fluorobenzoic acid Hydrogen Ethanol

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Preparation Products

2-AMINO-5-FLUOROACETOPHENONE 6-FLUOROQUINAZOLIN-4-ONE 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine 8-Bromo-6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 5-Fluoro-2-iodobenzoic acid

2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER

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2-Amino-5-fluorobenzoic acid Suppliers

Global( 457)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Taixing Foreign Trade Nanjing Co., Ltd.	+86-025-83346564; +8613182976929	sales@tx-chem.com	China	125	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+15184799099	lbaochemicals@gmail.com	China	671	58
Hubei Deli Pharmaceutical Technology Co., Ltd.	+8613372285931	dl@delipharm.com	China	97	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20125	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29827	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2952	58

Supplier	Advantage
Taixing Foreign Trade Nanjing Co., Ltd.	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Hubei Deli Pharmaceutical Technology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from 2-Amino-5-fluorobenzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-02	5-Fluoroanthranilic acid 446-08-2	US $0.00 / kg	1kg	98%	Customise	Hefei Lbao Physical & Chemical Science Co.,Ltd
2025-09-25	2-Amino-5-fluorobenzoic acid 446-08-2	US $5.00-0.10 / KG	1KG	98%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-04-04	2-Amino-5-fluorobenzoic acid 446-08-2	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

5-Fluoroanthranilic acid
446-08-2
US $0.00 / kg
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

2-Amino-5-fluorobenzoic acid
446-08-2
US $5.00-0.10 / KG
98%
Henan Fengda Chemical Co., Ltd

2-Amino-5-fluorobenzoic acid
446-08-2
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

2-Amino-5-fluorobenzoic acid Spectrum

2-Amino-5-fluorobenzoic acid(446-08-2)MS 2-Amino-5-fluorobenzoic acid(446-08-2)¹HNMR 2-Amino-5-fluorobenzoic acid(446-08-2)¹³CNMR 2-Amino-5-fluorobenzoic acid(446-08-2)IR1 2-Amino-5-fluorobenzoic acid(446-08-2)IR2 2-Amino-5-fluorobenzoic acid(446-08-2)IR3 2-Amino-5-fluorobenzoic acid(446-08-2)Raman

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2-AMINO-5-FLUOROBENZOIC ACID RARECHEM AL BO 2236 2-AMino-5-fluorobenzoic acid, 97% 1GR NSC 513308 2-aMino-5-fluorobenzoic aicd 2-Amino-5-fluorobenzoic acid 98% 5-Fluoroanthranilic acid, 2-Carboxy-4-fluoroaniline Anthranilic acid, 5-fluoro- Benzoic acid, 2-amino-5-fluoro- BUTTPARK 19\04-54 AURORA KA-5382 5-FluoroanthranilicAcid/2-Amino-5-FluorobenzoicAcid 2-Amino-5-fluoroBenzoicacid97. 2-Amino-5-fluorobenzoic Acid, 5-FAA 2-Amino-5-fluorobenzoic 5-FLUOROANTHRANILIC ACID 5-FAA 2-Amino-5-fluorobenzoic acid 97.5% 2-AMINO-5-FLUOROBENZOIC ACID 99+% 5-FLUOROANTHRANILIC ACID 98+% 5-Fluoroanthanilic acid 2-Amino-5-fluorobenzoic acid (5-Fluoroanthranilic acid) 2-Amino-5-fluorobenzoic acid, 98+% 2-Amino-5-fluorobenzoic Acid See: F587750 5-FluoroanthranilicAcid> 5-Fluoranthranilsure 2-Amino-5-fluorobenzoic acid,0.98 5-fluoroanthranilicaci Zavegepant Impurity 74 446-08-2 446-8-2 466-08-2 CARBOXYLIC ACID Aromatic Amino Acids Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Aromatics 5-FOA Bases & Related Reagents Nucleotides Benzoic acid Series Nucleotides and Nucleosides Aromatics Compounds Benzoic acid series Carboxylic Acids Phenyls & Phenyl-Het Amines FINE Chemical & INTERMEDIATES Fluorobenzene Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Carboxylic Acids Phenyls & Phenyl-Het Benzoic acid Fluorin-contained Benzoic acid series Fluorine series