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(R)-(-)-2-Amino-3-methyl-1-butanol

(R)-(-)-2-Amino-3-methyl-1-butanol Structure
(R)-(-)-2-Amino-3-methyl-1-butanol structure
CAS No.
4276-09-9
Chemical Name:
(R)-(-)-2-Amino-3-methyl-1-butanol
Synonyms
D-Val-ol;D-VALINOL;D-VALINAL;R-VALINOL;H-D-VAL-OL;(-)-D-VALINOL;D-(-)-VALINOL;D-Valinol, 97%;D-Valinol,99%e.e.;D-(-)-VALINOL 98%
CBNumber:
CB2173409
Molecular Formula:
C5H13NO
Molecular Weight:
103.16
MDL Number:
MFCD00064297
MOL File:
4276-09-9.mol
MSDS File:
SDS
Last updated:2025-09-10 18:36:46
Product description Number Pack Size Price
(R)-(?)-2-Amino-3-methyl-1-butanol 98% 284483 1g $24.66
(R)-(?)-2-Amino-3-methyl-1-butanol 98% 284483 5g $77.6
D-Valinol >98.0%(GC)(T) V0077 1g $33
D-Valinol >98.0%(GC)(T) V0077 5g $96
D-Valinol 237271 1g $156
More product size
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(R)-(-)-2-Amino-3-methyl-1-butanol Properties

Melting point 35-36 °C(lit.)
Boiling point 189-190 °C(lit.)
alpha -16.5 º (c=10, EtOH)
Density 0.931 g/mL at 20 °C(lit.)
refractive index n20/D 1.455
Flash point 194 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Low Melting Crystals or Crystalline Mass
pka 12.82±0.10(Predicted)
color White to light yellow
optical activity [α]20/D 16°, c = 10 in ethanol
Sensitive Air Sensitive
BRN 1719138
InChIKey NWYYWIJOWOLJNR-YFKPBYRVSA-N
CAS DataBase Reference 4276-09-9(CAS DataBase Reference)
FDA UNII 829QNS6ERZ
UNSPSC Code 12352116
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P305+P351+P338-P321-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37-36-36/37/38
WGK Germany  3
F  10-34
HS Code  29051990
NFPA 704
2
2 1

(R)-(-)-2-Amino-3-methyl-1-butanol price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 284483 (R)-(?)-2-Amino-3-methyl-1-butanol 98% 4276-09-9 1g $24.66 2025-07-31 Buy
Sigma-Aldrich 284483 (R)-(?)-2-Amino-3-methyl-1-butanol 98% 4276-09-9 5g $77.6 2025-07-31 Buy
TCI Chemical V0077 D-Valinol >98.0%(GC)(T) 4276-09-9 1g $33 2025-07-31 Buy
TCI Chemical V0077 D-Valinol >98.0%(GC)(T) 4276-09-9 5g $96 2025-07-31 Buy
Usbiological 237271 D-Valinol 4276-09-9 1g $156 2021-12-16 Buy
Product number Packaging Price Buy
284483 1g $24.66 Buy
284483 5g $77.6 Buy
V0077 1g $33 Buy
V0077 5g $96 Buy
237271 1g $156 Buy

(R)-(-)-2-Amino-3-methyl-1-butanol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

D-Valinol is used as a reagent in the synthesis of the HIV type 1 integrase inhibitor Elvitegravir (E509000). D-Valinol is also used in the preparation of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally active GSK-3β inhibitors for Alzheimer''s disease.

Synthesis

Methyl D-valinate hydrochloride

7146-15-8

(R)-(-)-2-Amino-3-methyl-1-butanol

4276-09-9

trans-3,6-Diisopropyl-2,5-Piperazinedione

19943-14-7

General procedure for the synthesis of D-valinol and compounds (CAS:19943-14-7) from D-valine methyl ester hydrochloride: Hydrogenation of R-phenylglycine methyl ester was carried out in a 0.5 L stainless steel electrolyzer with stirring at 500 rpm to test the catalyst activity. First, 1 g of catalyst (20-40 mesh) was loaded into the reactor and subsequently purged five times with H2 to remove air. The catalyst was reduced at 1 MPa H2 pressure and 250 °C for 4 hours. After the autoclave was cooled to room temperature in H2 atmosphere, 1.5 g of R-phenylglycine methyl ester (R-p-m) diluted by 150 mL of ethanol (R-p-m/Cat = 1.5, w/w) was added. The reaction conditions were set at 5 MPa H2 pressure and 80 °C temperature for 10 hours. Upon completion of the reaction, the autoclave was cooled to room temperature in H2 atmosphere, followed by separation of the solid catalyst by centrifugation. The product was purified by silica gel column chromatography using ethyl acetate/methanol (3/2, v/v) as eluent. Finally, the light yellow powdery product was obtained by rotary evaporation. The analysis of the reactants and products was carried out using a high performance liquid chromatograph (HPLC, Agilent 1260 Infinity) equipped with a UV detector and an Eclipse XDB-C18 column (150 × 4.6 mm, 5 μm particles), which in turn was used to calculate the conversion of R-phenylglycine methyl ester (X), yield (Y), and chemoselectivity for R-phenylglycine (S), where yield is the liquid chromatographic yield. The enantiomeric excess values (ee values) of the products were determined by HPLC equipped with a UV detector (wavelength 258 nm) and a chiral column (CHIRALPAK AY-H, 250 × 4.6 mm, 5 μm particle size).

References

[1] Catalysis Letters, 2017, vol. 147, # 8, p. 2160 - 2166

(R)-(-)-2-Amino-3-methyl-1-butanol synthesis

640-68-6
4276-09-9
Synthesis of (R)-(-)-2-Amino-3-methyl-1-butanol from D-Valine

(R)-(-)-2-Amino-3-methyl-1-butanol Preparation Products And Raw materials

Raw materials

Methyl D-valinate hydrochloride 70:3wt% Water Sodium carbonate Methyl glycolate
Ethanol Hydrogen

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Preparation Products

(R)-(+)-4-Isopropyl-2-oxazolidinone Carbamic acid, [(1S)-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester (9CI)

(R)-(-)-2-Amino-3-methyl-1-butanol Suppliers

Global( 367)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8772 58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		+8613288715578 sales@sichuanzyyt.com China 12247 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Zjartschem 		+86-571 87238903 jocelynpan@zjarts.com CHINA 988 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Zjartschem 		58
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58

View Lastest Price from (R)-(-)-2-Amino-3-methyl-1-butanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-(-)-2-Amino-3-methyl-1-butanol pictures 2025-10-17 (R)-(-)-2-Amino-3-methyl-1-butanol
4276-09-9
 US $0.00 / KG 1KG 98.0% 50kg/month WUHAN FORTUNA CHEMICAL CO., LTD
(R)-(-)-2-Amino-3-methyl-1-butanol pictures 2025-10-17 (R)-(-)-2-Amino-3-methyl-1-butanol
4276-09-9
 US $0.00-0.00 / KG 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
(R)-(-)-2-Amino-3-methyl-1-butanol pictures 2025-09-10 (R)-(-)-2-Amino-3-methyl-1-butanol
4276-09-9
 US $0.00 / KG 1KG 99% 50000KG/month Sichuan Zhuoyu Yantang Technology Co., Ltd.

(R)-(-)-2-Amino-3-methyl-1-butanol Spectrum

(R)-(-)-2-Amino-3-methyl-1-butanol(4276-09-9)1HNMR(R)-(-)-2-Amino-3-methyl-1-butanol(4276-09-9)IR(R)-(-)-2-Amino-3-methyl-1-butanol(4276-09-9)Raman

4276-09-9((R)-(-)-2-Amino-3-methyl-1-butanol)Related Search:

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2-AMINO-3-METHYLBUTAN-1-OL (R)-(-)-2-Amino-3-methyl-1-butanol 98% D-Valinol≥ 99% (GC) D-Valinol,99%e.e. (R)-(-)-2-AMINO-3-METHYLBUTANOL FOR SYNT （R）-2-Amino-3-mehylbutanol (R)-()-2-Amino-3-methyl-1-butanol,D-Valinol (R)-(-)-2-Amino-3-me (R)-(-)-2-AMino-3-Methyl-1-butanol, 98% 5GR (R)-(-)-2-AMino-3-Methyl-1-butanol, 95+% (R)-(-)-2-Amino-3-methyl-1-butanol, 98.5% (D)-VALINOL/(R)-(-)-2-AMINO-3-METHYL-1-BUTANOL (-)-D-VALINOL D-(-)-VALINOL D-VALINOL D-VALINAL D-2-AMINO-3-METHYL-1-BUTANOL H-D-VAL-OL R-VALINOL (R)-(-)-2-AMINO-3-METHYLBUTAN-1-OL (R)-(-)-2-AMINO-3-METHYLBUTANOL D-(-)-VALINOL 98% (R)-(-)-Z-Amino-3-Methyl-1-Butanol D-Val-ol D-(-)-Valinol,98% 1-Butanol, 2-amino-3-methyl-, (2R)- (R)-(-)-2-Amino-3-methyl-1-butanol (2R)-2-Amino-3-methyl-1-butanol (R)-3-Methyl-2-aminobutane-1-ol (R)-(-)-2-Amino-3-methyl-1-butanol,98% (R)-(-)-2-Amino-3-methylbutan-1-ol 98% (R)-(-)-2-Amino-3-methyL (R)-(-)-2-Amino-3-methyl-1-butanol USP/EP/BP Elvitegravir Impurity 5 (R)-(?)-2-Amino-3-methyl-1-butanol D-Valinol, 97% 4276-09-9 4276-O9-9 4276-9-9 868070 44276-09-9 427-69-9 4726-09-9 868-07-0 C5H13NO AMINE Organic Building Blocks Peptide Synthesis Specialty Synthesis Amino Alcohols (Chiral) Chiral Building Blocks Asymmetric Synthesis Amino Alcohols Amino Acid Derivatives Amino Alcohols (Chiral) Asymmetric Synthesis Chiral Building Blocks Synthetic Organic Chemistry