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(R)-(-)-2-Amino-3-methyl-1-butanol

(R)-(-)-2-Amino-3-methyl-1-butanol structure

CAS No.: 4276-09-9

Chemical Name:: (R)-(-)-2-Amino-3-methyl-1-butanol

Synonyms: D-VALINOL;2-AMINO-3-METHYLBUTAN-1-OL;D-Val-ol;D-VALINAL;R-VALINOL;H-D-VAL-OL;(-)-D-VALINOL;D-(-)-VALINOL;D-Valinol, 97%;D-Valinol,99%e.e.

CBNumber:: CB2173409

Molecular Formula:: C5H13NO

Molecular Weight:: 103.16

MDL Number:: MFCD00064297

MOL File:: 4276-09-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:56:57

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(R)-(-)-2-Amino-3-methyl-1-butanol Properties

Melting point	35-36 °C(lit.)
Boiling point	189-190 °C(lit.)
alpha	-16.5 º (c=10, EtOH)
Density	0.931 g/mL at 20 °C(lit.)
refractive index	n20/D 1.455
Flash point	194 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Low Melting Crystals or Crystalline Mass
pka	12.82±0.10(Predicted)
color	White to light yellow
optical activity	[α]20/D 16°, c = 10 in ethanol
Sensitive	Air Sensitive
BRN	1719138
InChI	1S/C5H13NO/c1-4(2)5(6)3-7/h4-5,7H,3,6H2,1-2H3/t5-/m0/s1
InChIKey	NWYYWIJOWOLJNR-YFKPBYRVSA-N
SMILES	CC(C)[C@@H](N)CO
CAS DataBase Reference	4276-09-9(CAS DataBase Reference)
FDA UNII	829QNS6ERZ
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P305+P351+P338-P321-P332+P313-P337+P313

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37-36-36/37/38

WGK Germany

10-34

HS Code

29051990

Storage Class

11 - Combustible Solids

NFPA 704

	2
2		1

(R)-(-)-2-Amino-3-methyl-1-butanol price More Price(91)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	284483	(R)-(?)-2-Amino-3-methyl-1-butanol 98%	4276-09-9	1g	$28.5	2026-04-30	Buy
Sigma-Aldrich	284483	(R)-(?)-2-Amino-3-methyl-1-butanol 98%	4276-09-9	5g	$82.7	2026-04-30	Buy
TCI Chemical	V0077	D-Valinol >98.0%(GC)(T)	4276-09-9	1g	$24	2026-04-30	Buy
TCI Chemical	V0077	D-Valinol >98.0%(GC)(T)	4276-09-9	5g	$75	2026-04-30	Buy
Usbiological	237271	D-Valinol		1g	$156	2026-06-03	Buy

Product number	Packaging	Price	Buy
284483	1g	$28.5	Buy
284483	5g	$82.7	Buy
V0077	1g	$24	Buy
V0077	5g	$75	Buy
237271	1g	$156	Buy

(R)-(-)-2-Amino-3-methyl-1-butanol Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

D-Valinol is used as a reagent in the synthesis of the HIV type 1 integrase inhibitor Elvitegravir (E509000). D-Valinol is also used in the preparation of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally active GSK-3β inhibitors for Alzheimer''s disease.

Synthesis

7146-15-8

4276-09-9

trans-3,6-Diisopropyl-2,5-Piperazinedione

19943-14-7

General procedure for the synthesis of D-valinol and compounds (CAS:19943-14-7) from D-valine methyl ester hydrochloride: Hydrogenation of R-phenylglycine methyl ester was carried out in a 0.5 L stainless steel electrolyzer with stirring at 500 rpm to test the catalyst activity. First, 1 g of catalyst (20-40 mesh) was loaded into the reactor and subsequently purged five times with H2 to remove air. The catalyst was reduced at 1 MPa H2 pressure and 250 °C for 4 hours. After the autoclave was cooled to room temperature in H2 atmosphere, 1.5 g of R-phenylglycine methyl ester (R-p-m) diluted by 150 mL of ethanol (R-p-m/Cat = 1.5, w/w) was added. The reaction conditions were set at 5 MPa H2 pressure and 80 °C temperature for 10 hours. Upon completion of the reaction, the autoclave was cooled to room temperature in H2 atmosphere, followed by separation of the solid catalyst by centrifugation. The product was purified by silica gel column chromatography using ethyl acetate/methanol (3/2, v/v) as eluent. Finally, the light yellow powdery product was obtained by rotary evaporation. The analysis of the reactants and products was carried out using a high performance liquid chromatograph (HPLC, Agilent 1260 Infinity) equipped with a UV detector and an Eclipse XDB-C18 column (150 × 4.6 mm, 5 μm particles), which in turn was used to calculate the conversion of R-phenylglycine methyl ester (X), yield (Y), and chemoselectivity for R-phenylglycine (S), where yield is the liquid chromatographic yield. The enantiomeric excess values (ee values) of the products were determined by HPLC equipped with a UV detector (wavelength 258 nm) and a chiral column (CHIRALPAK AY-H, 250 × 4.6 mm, 5 μm particle size).

References

[1] Catalysis Letters, 2017, vol. 147, # 8, p. 2160 - 2166

(R)-(-)-2-Amino-3-methyl-1-butanol synthesis

Synthesis of (R)-(-)-2-Amino-3-methyl-1-butanol from D-Valine

(R)-(-)-2-Amino-3-methyl-1-butanol Preparation Products And Raw materials

Raw materials

Methyl D-valinate hydrochloride 70:3wt% Water Sodium carbonate Methyl glycolate

Ethanol Hydrogen

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Preparation Products

(R)-(+)-4-Isopropyl-2-oxazolidinone Carbamic acid, [(1S)-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester (9CI)

(R)-(-)-2-Amino-3-methyl-1-butanol Suppliers

Global Suppliers ( 368)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Welt Chem. Co.,Ltd.	531-87153728 13805401165	xufeng192@126.com	China	5858	58
Yanggu Rongke Trading Co. , Ltd.	0635-6725226 15863541132	yglida@163.com	China	61	65
Shandong Welt Chem. Co .Ltd	531-87153728 13805401165	xufeng192@126.com	China	106	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
PharmaBlock Sciences (Nanjing),Inc.	025-86918202 4000255188	sales@pharmablock.com	China	5000	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
ITIC MEDCHEM(SUZHOU) CO.,LTD.	0512-68323967 18015559028	sales@iticmedchem.com	China	528	61
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Shandong Welt Chem. Co.,Ltd.	58
Yanggu Rongke Trading Co. , Ltd.	65
Shandong Welt Chem. Co .Ltd	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
PharmaBlock Sciences (Nanjing),Inc.	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
ITIC MEDCHEM(SUZHOU) CO.,LTD.	61
Alfa Aesar	84

View Latest Price from (R)-(-)-2-Amino-3-methyl-1-butanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	(R)-(-)-2-Amino-3-methyl-1-butanol 4276-09-9		1KG	98.0%	50kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	(R)-(-)-2-Amino-3-methyl-1-butanol 4276-09-9		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2021-07-13	(R)-(-)-2-Amino-3-methyl-1-butanol 4276-09-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

(R)-(-)-2-Amino-3-methyl-1-butanol
4276-09-9
$0.00
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

(R)-(-)-2-Amino-3-methyl-1-butanol
4276-09-9
99%
Hebei Chuanghai Biotechnology Co., Ltd

(R)-(-)-2-Amino-3-methyl-1-butanol
4276-09-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(R)-(-)-2-Amino-3-methyl-1-butanol Spectrum

(R)-(-)-2-Amino-3-methyl-1-butanol(4276-09-9)¹HNMR (R)-(-)-2-Amino-3-methyl-1-butanol(4276-09-9)IR (R)-(-)-2-Amino-3-methyl-1-butanol(4276-09-9)Raman

4276-09-9 ((R)-(-)-2-Amino-3-methyl-1-butanol) Related Search:

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(R)-(-)-2-Amino-3-methyl-1-butanol 98% D-Valinol≥ 99% (GC) D-Valinol,99%e.e. (R)-(-)-2-AMINO-3-METHYLBUTANOL FOR SYNT （R）-2-Amino-3-mehylbutanol (R)-()-2-Amino-3-methyl-1-butanol,D-Valinol (R)-(-)-2-Amino-3-me (R)-(-)-2-AMino-3-Methyl-1-butanol, 98% 5GR (R)-(-)-2-AMino-3-Methyl-1-butanol, 95+% (R)-(-)-2-Amino-3-methyl-1-butanol, 98.5% (D)-VALINOL/(R)-(-)-2-AMINO-3-METHYL-1-BUTANOL (-)-D-VALINOL D-(-)-VALINOL D-VALINAL D-2-AMINO-3-METHYL-1-BUTANOL H-D-VAL-OL R-VALINOL (R)-(-)-2-AMINO-3-METHYLBUTAN-1-OL (R)-(-)-2-AMINO-3-METHYLBUTANOL D-(-)-VALINOL 98% (R)-(-)-Z-Amino-3-Methyl-1-Butanol D-(-)-Valinol,98% 1-Butanol, 2-amino-3-methyl-, (2R)- (R)-(-)-2-Amino-3-methyl-1-butanol (2R)-2-Amino-3-methyl-1-butanol (R)-3-Methyl-2-aminobutane-1-ol (R)-(-)-2-Amino-3-methyl-1-butanol,98% (R)-(-)-2-Amino-3-methylbutan-1-ol 98% (R)-(-)-2-Amino-3-methyL (R)-(-)-2-Amino-3-methyl-1-butanol USP/EP/BP Elvitegravir Impurity 5 (R)-(?)-2-Amino-3-methyl-1-butanol D-Valinol, 97% 2-AMINO-3-METHYLBUTAN-1-OL D-VALINOL D-Val-ol 4276-09-9 4276-O9-9 4276-9-9 868070 44276-09-9 427-69-9 4726-09-9 868-07-0 4270-09-9 C5H13NO AMINE Organic Building Blocks Peptide Synthesis Specialty Synthesis Amino Alcohols (Chiral) Chiral Building Blocks Asymmetric Synthesis Amino Alcohols Amino Acid Derivatives Amino Alcohols (Chiral) Asymmetric Synthesis Chiral Building Blocks